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Detachment of molecular motors under tangential loading

A. Parmeggiani·F. Julicher·L. Peliti·J. Prost
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Abstract

We introduce a general framework to study the processivity of molecular motors moving along a polar filament and discuss the average time spent attached to the filament as a function of a tangentially applied load. Our study of specific models suggests that the attachment time of a motor decreases with increasing ATP concentration and that double-headed motors such as kinesins lose their processivity under forcing conditions while processive single-headed motors are less sensitive to tangential forcing.

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A. Parmeggiani, F. Julicher, L. Peliti, J. Prost. 2001-09-11. Detachment of molecular motors under tangential loading. https://doi.org/10.1209/epl%2Fi2001-00563-6

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