Dynamin recruitment by clathrin coats: a physical step?

J. -B. Fournier; P. -G. Dommersnes; P. Galatola

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arXiv · cond-mat/0301257

Dynamin recruitment by clathrin coats: a physical step?

J. -B. Fournier·P. -G. Dommersnes·P. Galatola

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Abstract

Recent structural findings have shown that dynamin, a cytosol protein playing a key-role in clathrin-mediated endocytosis, inserts partly within the lipid bilayer and tends to self-assemble around lipid tubules. Taking into account these observations, we make the hypothesis that individual membrane inserted dynamins imprint a local cylindrical curvature to the membrane. This imprint may give rise to long-range mechanical forces mediated by the elasticity of the membrane. Calculating the resulting many-body interaction between a collection of inserted dynamins and a membrane bud, we find a regime in which the dynamins are elastically recruited by the bud to form a collar around its neck, which is reminiscent of the actual process preempting vesicle scission. This physical mechanism might therefore be implied in the recruitment of dynamins by clathrin coats.

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J. -B. Fournier, P. -G. Dommersnes, P. Galatola. 2003-01-15. Dynamin recruitment by clathrin coats: a physical step?. https://arxiv.org/abs/cond-mat/0301257

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