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Extracting Structural Information of a Heteropolymer from Force-Extension Curves

E. Jarkova·Nam-Kyung Lee·S. Obukhov
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Abstract

We present a theory for the reverse analysis on the sequence information of a single H/P two-letter random hetero-polymer (RHP) from its force-extension(f-z) curves during quasi static stretching. Upon stretching of a self-assembled RHP, it undergoes several structural transitions. The typical elastic response of a hetero-polymeric globule is a set of overlapping saw-tooth patterns. With consideration of the height and the position of the overlapping saw-tooth shape, we analyze the possibility of extracting the binding energies of the internal domains and the corresponding block sizes of the contributing conformations.

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E. Jarkova, Nam-Kyung Lee, S. Obukhov. 2004-12-15. Extracting Structural Information of a Heteropolymer from Force-Extension Curves. https://doi.org/10.1021/ma047965d

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