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Fast DNA Sequencing via Transverse Electronic Transport

Johan Lagerqvist·Michael Zwolak·Massimiliano Di Ventra
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Abstract

A rapid and low-cost method to sequence DNA would usher in a revolution in medicine. We propose and theoretically show the feasibility of a protocol for sequencing based on the distributions of transverse electrical currents of single-stranded DNA while it translocates through a nanopore. Our estimates, based on the statistics of these distributions, reveal that sequencing of an entire human genome could be done with very high accuracy in a matter of hours without parallelization, e.g., orders of magnitude faster than present techniques. The practical implementation of our approach would represent a substantial advancement in our ability to study, predict and cure diseases from the perspective of the genetic makeup of each individual.

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Johan Lagerqvist, Michael Zwolak, Massimiliano Di Ventra. 2006-03-01. Fast DNA Sequencing via Transverse Electronic Transport. https://doi.org/10.1021/nl0601076

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