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arXiv · cond-mat/9704167

Stability Threshold as a Selection Principle for Protein Design

Michele Vendruscolo·Amos Maritan·Jayanth R. Banavar
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Abstract

The sensitivity of the native states of protein-like heteropolymers to mutations modelled as perturbations in the interaction potential between amino acids is studied. The stability threshold against mutations is shown to be zero for random heteropolymers on a lattice in two dimensions, whereas a design procedure modelling evolution produces a non-zero threshold. We introduce an evolution-like protein design procedure based on an optimization of the stability threshold that is shown to naturally ensure thermodynamic stability as well.

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Michele Vendruscolo, Amos Maritan, Jayanth R. Banavar. 1997-04-20. Stability Threshold as a Selection Principle for Protein Design. https://doi.org/10.1103/physrevlett.78.3967

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