An Analytical Approach to the Protein Designability Problem

Edo L. Kussell; Eugene I. Shakhnovich

doi:10.1103/physrevlett.83.4437

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arXiv · cond-mat/9904377

An Analytical Approach to the Protein Designability Problem

Edo L. Kussell·Eugene I. Shakhnovich

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Abstract

We present an analytical method for determining the designability of protein structures. We apply our method to the case of two-dimensional lattice structures, and give a systematic solution for the spectrum of any structure. Using this spectrum, the designability of a structure can be estimated. We outline a heirarchy of structures, from most to least designable, and show that this heirarchy depends on the potential that is used.

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Edo L. Kussell, Eugene I. Shakhnovich. 1999-04-27. An Analytical Approach to the Protein Designability Problem. https://doi.org/10.1103/physrevlett.83.4437

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