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Complexation of DNA with Cationic Surfactant

P. S. Kuhn·Marcia C. Barbosa·Y. Levin
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Abstract

Transfection of an anionic polynucleotide through a negatively charged membrane is an important problem in genetic engineering. The direct association of cationic surfactant to DNA decreases the effective negative charge of the nucleic acid, allowing the DNA-surfactant complex to approach a negatively charged membrane. The paper develops a theory for solutions composed of polyelectrolyte, salt, and ionic surfactant. The theoretical predictions are compared with the experimental measurements.

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P. S. Kuhn, Marcia C. Barbosa, Y. Levin. 1999-04-30. Complexation of DNA with Cationic Surfactant. https://doi.org/10.1016/s0378-4371(99)00184-3

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