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Destruction of CD4 T Lymphocytes Alone Cannot Account for their Long-term Decrease in AIDS

Yoram Louzoun·Irun. R. Cohen·Henri Atlan
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Abstract

Following previous models describing a quasi steady state (QSS) for the evolution of HIV infection and AIDS, we have developed a larger formalism simulating the long-term evolution of the QSS We show that the long-term evolution of AIDS cannot be explained by the destruction alone of CD4 T cells, either directly or indirectly. The destruction of CD4 T cells can lead only to a QSS with a lower concentration of CD4 T cells, but CD4 destruction cannot generate the sustained long-term decrease in T cells leading to AIDS. We here suggest some workable explanations.

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Yoram Louzoun, Irun. R. Cohen, Henri Atlan. 2000-08-07. Destruction of CD4 T Lymphocytes Alone Cannot Account for their Long-term Decrease in AIDS. https://arxiv.org/abs/math/0008052

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