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Compositional representation of protein sequences and the number of Eulerian loops

Bailin Hao·Huimin Xie·Shuyu Zhang
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Abstract

An amino acid sequence of a protein may be decomposed into consecutive overlapping strings of length K. How unique is the converse, i.e., reconstruction of amino acid sequences using the set of K-strings obtained in the decomposition? This problem may be transformed into the problem of counting the number of Eulerian loops in an Euler graph, though the well-known formula must be modified. By exhaustive enumeration and by using the modified formula we show that the reconstruction is unique at K equal or greater than 5 for an overwhelming majority of the proteins in the PDB.seq database. The corresponding Euler graphs provide a means to study the structure of repeated segments in protein sequences.

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Bailin Hao, Huimin Xie, Shuyu Zhang. 2001-03-10. Compositional representation of protein sequences and the number of Eulerian loops. https://arxiv.org/abs/physics/0103028

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