Peptide size dependent active transport in the proteasome

Alexei Zaikin; Thorsten Poeschel

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arXiv · q-bio/0311036

Peptide size dependent active transport in the proteasome

Alexei Zaikin·Thorsten Poeschel

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Abstract

We investigate the transport of proteins inside the proteasome and propose an active transport mechanism based on a spatially asymmetric interaction potential of peptide chains. The transport is driven by fluctuations which are always present in such systems. We compute the peptide-size dependent transport rate which is essential for the functioning of the proteasome. In agreement with recent experiments, varying temperature changes the transport mechanism qualitatively.

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Alexei Zaikin, Thorsten Poeschel. 2004-06-21. Peptide size dependent active transport in the proteasome. https://arxiv.org/abs/q-bio/0311036

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