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Correlations in the T Cell Response to Altered Peptide Ligands

Jeong-Man Park·Michael W. Deem
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Abstract

The vertebrate immune system is a wonder of modern evolution. Occasionally, however, correlations within the immune system lead to inappropriate recruitment of preexisting T cells against novel viral diseases. We present a random energy theory for the correlations in the naive and memory T cell immune responses. The non-linear susceptibility of the random energy model to structural changes captures the correlations in the immune response to mutated antigens. We show how the sequence-level diversity of the T cell repertoire drives the dynamics of the immune response against mutated viral antigens.

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BibTeXRIS

Jeong-Man Park, Michael W. Deem. 2004-04-20. Correlations in the T Cell Response to Altered Peptide Ligands. https://doi.org/10.1016/j.physa.2004.04.127

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