Unidentifiable divergence times in rates-across-sites models

Steven N. Evans; Tandy Warnow

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arXiv · q-bio/0408011

Unidentifiable divergence times in rates-across-sites models

Steven N. Evans·Tandy Warnow

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Abstract

The rates-across-sites assumption in phylogenetic inference posits that the rate matrix governing the Markovian evolution of a character on an edge of the putative phylogenetic tree is the product of a character-specific scale factor and a rate matrix that is particular to that edge. Thus, evolution follows basically the same process for all characters, except that it occurs faster for some characters than others. To allow estimation of tree topologies and edge lengths for such models, it is commonly assumed that the scale factors are not arbitrary unknown constants, but rather unobserved, independent, identically distributed draws from a member of some parametric family of distributions. A popular choice is the gamma family. We consider an example of a clock-like tree with three taxa, one unknown edge length, and a parametric family of scale factor distributions that contain the gamma family. This model has the property that, for a generic choice of unknown edge length and scale factor distribution, there is another edge length and scale factor distribution which generates data with exactly the same distribution, so that even with infinitely many data it will be typically impossible to make correct inferences about the unknown edge length.

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BibTeX RIS

Steven N. Evans, Tandy Warnow. 2004-11-22. Unidentifiable divergence times in rates-across-sites models. https://arxiv.org/abs/q-bio/0408011

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