Robustness in Gene Circuits: Clustering of Functional Responses

Mary J. Dunlop; Michael E. Wall

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arXiv · q-bio/0503005

Robustness in Gene Circuits: Clustering of Functional Responses

Mary J. Dunlop·Michael E. Wall

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Abstract

In contrast to engineering applications, in which the structure of control laws are designed to satisfy prescribed function requirements, in biology it is often necessary to infer gene-circuit function from incomplete data on gene-circuit structure. By using the feed-forward loop as a model system, this paper introduces a technique for classifying gene-circuit function given gene-circuit structure. In simulations performed on a comprehensive set of models that span a broad range of parameter space, some designs are robust, producing one unique type of functional response regardless of parameter selection. Other designs may exhibit a variety of functional responses, depending upon parameter values. We conclude that, although some feed-forward loop models have designs that lend themselves to unique function inference, others have designs for which the function type may be uncertain.

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Mary J. Dunlop, Michael E. Wall. 2005-03-01. Robustness in Gene Circuits: Clustering of Functional Responses. https://arxiv.org/abs/q-bio/0503005

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