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Yeast Protein Interactome Topology Provides Framework for Coordinated-Functionality

Andre X. C. N. Valente·Michael E. Cusick
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Abstract

The architecture of the network of protein-protein physical interactions in Saccharomyces cerevisiae is exposed through the combination of two complementary theoretical network measures, betweenness centrality and `Q-modularity'. The yeast interactome is characterized by well-defined topological modules connected via a small number of inter-module protein interactions. Should such topological inter-module connections turn out to constitute a form of functional coordination between the modules, we speculate that this coordination is occurring typically in a pair-wise fashion, rather than by way of high-degree hub proteins responsible for coordinating multiple modules. The unique non-hub-centric hierarchical organization of the interactome is not reproduced by gene duplication-and-divergence stochastic growth models that disregard global selective pressures.

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Andre X. C. N. Valente, Michael E. Cusick. 2006-05-24. Yeast Protein Interactome Topology Provides Framework for Coordinated-Functionality. https://doi.org/10.1093/nar%2Fgkl325

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