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Modeling the Role of the Cell Cycle in Regulating Proteus mirabilis Swarm-Colony Development

Bruce P. Ayati
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Abstract

We present models and computational results which indicate that the spatial and temporal regularity seen in Proteus mirabilis swarm-colony development is largely an expression of a sharp age of dedifferentiation in the cell cycle from motile swarmer cells to immotile dividing cells (also called swimmer or vegetative cells.) This contrasts strongly with reaction-diffusion models of Proteus behavior that ignore or average out the age structure of the cell population and instead use only density-dependent mechanisms. We argue the necessity of retaining the explicit age structure, and suggest experiments that may help determine the underlying mechanisms empirically. Consequently, we advocate Proteus as a model organism for a multiscale understanding of how and to what extent the life cycle of individual cells affects the macroscopic behavior of a biological system.

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Bruce P. Ayati. 2005-07-15. Modeling the Role of the Cell Cycle in Regulating Proteus mirabilis Swarm-Colony Development. https://doi.org/10.1016/j.aml.2006.11.003

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