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Thermal unfolding of proteins

Marek Cieplak·Joanna I. Sulkowska
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Abstract

Thermal unfolding of proteins is compared to folding and mechanical stretching in a simple topology-based dynamical model. We define the unfolding time and demonstrate its low-temperature divergence. Below a characteristic temperature, contacts break at separate time scales and unfolding proceeds approximately in a way reverse to folding. Features in these scenarios agree with experiments and atomic simulations on titin.

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Marek Cieplak, Joanna I. Sulkowska. 2006-01-30. Thermal unfolding of proteins. https://doi.org/10.1063/1.2121668

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