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Targeted Projection Pursuit for Gene Expression Data Classification and Visualisation

J. Faith·R. Mintram·M. Angelova
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Abstract

We present a novel method for finding low dimensional views of high dimensional data: Targeted Projection Pursuit. The method proceeds by finding projections of the data that best approximate a target view. Two versions of the method are introduced; one version based on Procrustes analysis and one based on a single layer perceptron. These versions are capable of finding orthogonal or non-orthogonal projections respectively. The method is quantitatively and qualitatively compared with other dimension reduction techniques. It is shown to find two-dimensional views that display the classification of cancers from gene expression data with a visual separation equal to, or better than, existing dimension reduction techniques.

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J. Faith, R. Mintram, M. Angelova. 2006-05-17. Targeted Projection Pursuit for Gene Expression Data Classification and Visualisation. https://arxiv.org/abs/q-bio/0605028

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