Is the intrinsic disorder of proteins the cause of the scale-free architecture of protein-protein interaction networks?

Santiago Schnell; Santo Fortunato; Sourav Roy

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Is the intrinsic disorder of proteins the cause of the scale-free architecture of protein-protein interaction networks?

Santiago Schnell·Santo Fortunato·Sourav Roy

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Abstract

In protein-protein interaction networks certain topological properties appear to be recurrent: networks maps are considered scale-free. It is possible that this topology is reflected in the protein structure. In this paper we investigate the role of protein disorder in the network topology. We find that the disorder of a protein (or of its neighbors) is independent of its number of protein-protein interactions. This result suggests that protein disorder does not play a role in the scale-free architecture of protein networks.

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Santiago Schnell, Santo Fortunato, Sourav Roy. 2006-06-22. Is the intrinsic disorder of proteins the cause of the scale-free architecture of protein-protein interaction networks?. https://arxiv.org/abs/q-bio/0606029

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