arXiv subjects

A. Andrighetto

Publications and source records attributed to A. Andrighetto.

3 recordsLinked to original sources

arXiv2025

Monte Carlo simulation of the ISOLPHARM gamma camera for Ag-111 imaging

Targeted Radionuclide Therapy (TRT) is a well-established technique for cancer treatment. In this approach, radionuclides are bound to specific drugs that selectively transport them to the tumor site. Within the ISOLPHARM project, a radiopharmaceutical for TRT based on the innovative radionuclide Ag-111 is currently under development. Ag-111 has a half-life of 7.45 days and decays by emitting both electrons and gamma-rays. The emission of gamma-rays, predominantly at an energy of 342 keV, enables the visualization of Ag-111 using a gamma camera. In this work, we describe a Monte Carlo simulation developed to optimize the design parameters of such an imaging device. The simulation is based on the Geant4 toolkit, which accurately models the interactions between particles and matter. The estimated spatial resolution and sensitivity of the system are approximately 4 mm and 19 cps/MBq, respectively. The simulated device is able to resolve lesions with a lesion-to-background activity ratio of 4:1 under in-vivo-like conditions. These results indicate that the proposed gamma camera can provide cost-effective imaging capabilities for preclinical radiopharmaceutical studies.

physics.med-ph↗

arXiv1995

Strangeness Enhancement in $p+A$ and $S+A$ Interactions at SPS Energies

The systematics of strangeness enhancement is calculated using the HIJING and VENUS models and compared to recent data on $\,pp\,$, $\,pA\,$ and $\,AA\,$ collisions at CERN/SPS energies ($200A\,\, GeV\,$). The HIJING model is used to perform a {\em linear} extrapolation from $pp$ to $AA$. VENUS is used to estimate the effects of final state cascading and possible non-conventional production mechanisms. This comparison shows that the large enhancement of strangeness observed in $S+Au$ collisions, interpreted previously as possible evidence for quark-gluon plasma formation, has its origins in non-equilibrium dynamics of few nucleon systems. % Strangeness enhancement %is therefore traced back to the change in the production dynamics %from $pp$ to minimum bias $pS$ and central $SS$ collisions. A factor of two enhancement of $Λ^{0}$ at mid-rapidity is indicated by recent $pS$ data, where on the average {\em one} projectile nucleon interacts with only {\em two} target nucleons. There appears to be another factor of two enhancement in the light ion reaction $SS$ relative to $pS$, when on the average only two projectile nucleons interact with two target ones.

nucl-th↗

arXiv1994

Strangeness Production in pp,pA,AA Interactions at SPS Energies.HIJING Approach

In this report we have made a systematic study of strangeness production in proton-proton(pp),proton-nucleus(pA) and nucleus- nucleus(AA) collisions at CERN Super Proton Synchroton energies, using$\,\,\, HIJING\,\,\, MONTE \,\,\,CARLO \,\,\,MODEL $ \\ (version $HIJ.01$). Numerical results for mean multiplicities of neutral strange particles ,as well as their ratios to negatives hadrons($ $) for p-p,nucleon-nucleon(N-N),\,\,p-S,\,\,p-Ag,\,\,p-Au('min. bias')collisions and p-Au,\,\,S-S,\,\,S-Ag,\,\,S-Au ('central')collisions are compared to experimental data available from CERN experiments and also with recent theoretical estimations given by others models. Neutral strange particle abundances are quite well described for p-p,N-N and p-A interactions ,but are underpredicted by a factor of two in A-A interactions for $Λ,\barΛ, K^{0}_{S}$ in symmetric collisions(S-S,\,\,Pb-Pb)and for $Λ,\barΛ\,\,$in asymmetric ones(S-Ag,\,\,S-Au,\,\,S-W). A qualitative prediction for rapidity, transverse kinetic energy and transverse momenta normalized distributions are performed at 200 GeV/Nucleon in p-S,S-S,S-Ag and S-Au collisions in comparison with recent experimental data. HIJING model predictions for coming experiments at CERN for S-Au, S-W and Pb-Pb interactions are given. The theoretical calculations are estimated in a full phase space.

hep-ph↗