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A. Laszkiewicz

Publications and source records attributed to A. Laszkiewicz.

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Scaling effects in the Penna ageing model

We have analysed the possibility of scaling the sexual Penna ageing model. Assuming that the number of genes expressed before the reproduction age grows linearly with the genome size and that the mutation rate per genome and generation is constant, we have found that the fraction of defective genes expressed before the minimum reproduction age drops with the genome size, while the number of defective genes eliminated by the genetic death grows with genome size. Thus, the evolutionary costs decrease with enlarging the genome. After rescaling the time scale according to the mutational clock, age distributions of populations do not depend on the genome size. Nevertheless, enlarging the genome increases the reproduction potential of populations.

q-bio.PE

Prediction of the human life expectancy

We have simulated demographic changes in the human population using the Penna microscopic model, based on the simple Monte Carlo method. The results of simulations have shown that during a few generations changes in the genetic pool of a population are negligible, while improving the methods of compensation of genetic defects or genetically determined proneness to many disorders drastically affects the average life span of organisms. Age distribution and mortality of the simulated populations correspond very well to real demographic data available from different countries. Basing on the comparison of structures of real human populations and the results of simulations it is possible to predict changes in the age structure of populations in the future.

cond-mat.stat-mech