A. S. Kuznetsov — Page 2

arXiv2012

Exploring Neuronal Bistability at the Depolarization Block

Many neurons display bistability - coexistence of two firing modes such as bursting and tonic spiking or tonic spiking and silence. Bistability has been proposed to endow neurons with richer forms of information processing in general and to be involved in short-term memory in particular by allowing a brief signal to elicit long-lasting changes in firing. In this paper, we focus on bistability that allows for a choice between tonic spiking and depolarization block in a wide range of the depolarization levels. We consider the spike-producing currents in two neurons, models of which differ by the parameter values. Our dopaminergic neuron model displays bistability in a wide range of applied currents at the depolarization block. The Hodgkin-Huxley model of the squid giant axon shows no bistability. We varied parameter values for the model to analyze transitions between the two parameter sets. We show that bistability primarily characterizes the inactivation of the Na+ current. Our study suggests a connection between the amount of the Na+ window current and the length of the bistability range. For the dopaminergic neuron we hypothesize that bistability can be linked to a prolonged action of antipsychotic drugs.

q-bio.NC↗

arXiv2007

Optical Observations of Gamma-Ray Bursts, the Discovery of Supernovae 2005bv, 2005ee, and 2006ak, and Searches for Transients Using the "MASTER" Robotic Telescope

We present the results of observations obtained using the MASTER robotic telescope in 2005 - 2006, including the earliest observations of the optical emission of the gamma-ray bursts GRB 050824 and GRB 060926. Together with later observations, these data yield the brightness-variation law t^{-0.55+-0.05} for GRB 050824. An optical flare was detected in GRB 060926 - a brightness enhancement that repeated the behavior observed in the X-ray variations. The spectrum of GRB 060926 is found to be F_E ~ E^-β, where β= 1.0+-0.2. Limits on the optical brightnesses of 26 gamma-ray bursts have been derived, 9 of these for the first time. Data for more than 90% of the accessible sky down to $19^m$ were taken and reduced in real time during the survey. A database has been composed based on these data. Limits have been placed on the rate of optical flares that are not associated with detected gamma-ray bursts, and on the opening angle for the beams of gamma-ray bursts. Three new supernovae have been discovered: SN 2005bv (type Ia) - the first to be discovered on Russian territory, SN 2005ee - one of the most powerful type II supernovae known, and SN 2006ak (type Ia). We have obtained an image of SN 2006X during the growth stage and a light curve that fully describes the brightness maximum and exponential decay. A new method for searching for optical transients of gamma-ray bursts detected using triangulation from various spacecraft is proposed and tested.

astro-ph↗