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A. Siegel

Publications and source records attributed to A. Siegel.

6 recordsLinked to original sources

A model for regulated fatty acid metabolism in liver; equilibria and their changes

We build a model for the hepatic fatty acid metabolism and its metabolic and genetic regulations. The model has two functioning modes: synthesis and oxidation of fatty acids. We provide a sufficient condition (the strong lipolytic condition) for the uniqueness of its equilibrium. Under this condition, modifications of the glucose input produce equilibrium shifts, which are gradual changes from one functioning mode to the other. We also discuss the concentration variations of various metabolites during equilibrium shifts. The model can explain a certain amount of experimental observations, assess the role of poly-unsaturated fatty acids in genetic regulation, and predict the behavior of mutants. The analysis of the model is based on block elimination of variables and uses a modular decomposition of the system dictated by mathematical global univalence conditions.

q-bio.CB

Crushing of interstellar gas clouds in supernova remnants. I. The role of thermal conduction and radiative losses

We model the hydrodynamic interaction of a shock wave of an evolved supernova remnant with a small interstellar gas cloud like the ones observed in the Cygnus loop and in the Vela SNR. We investigate the interplay between radiative cooling and thermal conduction during cloud evolution and their effect on the mass and energy exchange between the cloud and the surrounding medium. Through the study of two cases characterized by different Mach numbers of the primary shock (M = 30 and 50, corresponding to a post-shock temperature $T\approx 1.7\times 10^6$ K and $\approx 4.7\times 10^6$ K, respectively), we explore two very different physical regimes: for M = 30, the radiative losses dominate the evolution of the shocked cloud which fragments into cold, dense, and compact filaments surrounded by a hot corona which is ablated by the thermal conduction; instead, for M = 50, the thermal conduction dominates the evolution of the shocked cloud, which evaporates in a few dynamical time-scales. In both cases we find that the thermal conduction is very effective in suppressing the hydrodynamic instabilities that would develop at the cloud boundaries.

astro-ph

Morphology of Rising Hydrodynamic and Magneto-hydrodynamic Bubbles from Numerical Simulations

Recent Chandra and XMM-Newton observations of galaxy cluster cooling flows have revealed X-ray emission voids of up to 30 kpc in size that have been identified with buoyant, magnetized bubbles. Motivated by these observations, we have investigated the behavior of rising bubbles in stratified atmospheres using the FLASH adaptive-mesh simulation code. We present results from 2-D simulations with and without the effects of magnetic fields, and with varying bubble sizes and background stratifications. We find purely hydrodynamic bubbles to be unstable; a dynamically important magnetic field is required to maintain a bubble's integrity. This suggests that, even absent thermal conduction, for bubbles to be persistent enough to be regularly observed, they must be supported in large part by magnetic fields. Thermal conduction unmitigated by magnetic fields can dissipate the bubbles even faster. We also observe that the bubbles leave a tail as they rise; the structure of these tails can indicate the history of the dynamics of the rising bubble.

astro-ph

The Response of Model and Astrophysical Thermonuclear Flames to Curvature and Stretch

Critically understanding the `standard candle'-like behavior of Type Ia supernovae requires understanding their explosion mechanism. One family of models for Type Ia Supernovae begins with a deflagration in a Carbon-Oxygen white dwarf which greatly accelerates through wrinkling and flame instabilities. While the planar speed and behavior of astrophysically-relevant flames is increasingly well understood, more complex behavior, such as the flame's response to stretch and curvature, has not been extensively explored in the astrophysical literature; this behavior can greatly enhance or suppress instabilities and local flame-wrinkling, which in turn can increase or decrease the bulk burning rate. In this paper, we explore the effects of curvature on both nuclear flames and simpler model flames to understand the effect of curvature on the flame structure and speed.

astro-ph

Mapping Initial Hydrostatic Models in Godunov Codes

We look in detail at the process of mapping an astrophysical initial model from a stellar evolution code onto the computational grid of an explicit, Godunov type code while maintaining hydrostatic equilibrium. This mapping process is common in astrophysical simulations, when it is necessary to follow short-timescale dynamics after a period of long timescale buildup. We look at the effects of spatial resolution, boundary conditions, the treatment of the gravitational source terms in the hydrodynamics solver, and the initialization process itself. We conclude with a summary detailing the mapping process that yields the lowest ambient velocities in the mapped model.

astro-ph