arXiv subjects

A. Stefanovska

Publications and source records attributed to A. Stefanovska.

4 recordsLinked to original sources

arXiv2009

Intrinsic dynamics of heart regulatory systems on short time-scales: from experiment to modelling

We discuss open problems related to the stochastic modeling of cardiac function. The work is based on an experimental investigation of the dynamics of heart rate variability (HRV) in the absence of respiratory perturbations. We consider first the cardiac control system on short time scales via an analysis of HRV within the framework of a random walk approach. Our experiments show that HRV on timescales of less than a minute takes the form of free diffusion, close to Brownian motion, which can be described as a non-stationary process with stationary increments. Secondly, we consider the inverse problem of modeling the state of the control system so as to reproduce the experimentally observed HRV statistics of. We discuss some simple toy models and identify open problems for the modelling of heart dynamics.

physics.bio-ph↗

arXiv2009

Diverse routes to oscillation death in a coupled oscillator system

We study oscillation death (OD) in a well-known coupled-oscillator system that has been used to model cardiovascular phenomena. We derive exact analytic conditions that allow the prediction of OD through the two known bifurcation routes, in the same model, and for different numbers of coupled oscillators. Our exact analytic results enable us to generalize OD as a multiparameter-sensitive phenomenon. It can be induced, not only by changes in couplings, but also by changes in the oscillator frequencies or amplitudes. We observe synchronization transitions as a function of coupling and confirm the robustness of the phenomena in the presence of noise. Numerical and analogue simulations are in good agreement with the theory.

nlin.AO↗

arXiv2005

Nonlinear Statistical Modelling and Model Discovery for Cardiorespiratory Data

We present a Bayesian dynamical inference method for characterizing cardiorespiratory (CR) dynamics in humans by inverse modelling from blood pressure time-series data. This new method is applicable to a broad range of stochastic dynamical models, and can be implemented without severe computational demands. A simple nonlinear dynamical model is found that describes a measured blood pressure time-series in the primary frequency band of the CR dynamics. The accuracy of the method is investigated using surrogate data with parameters close to the parameters inferred in the experiment. The connection of the inferred model to a well-known beat-to-beat model of the baroreflex is discussed.

physics.data-an↗

arXiv2005

Inference of a nonlinear stochastic model of the cardiorespiratory interaction

A new technique is introduced to reconstruct a nonlinear stochastic model of the cardiorespiratory interaction. Its inferential framework uses a set of polynomial basis functions representing the nonlinear force governing the system oscillations. The strength and direction of coupling, and the noise intensity are simultaneously inferred from a univariate blood pressure signal, monitored in a clinical environment. The technique does not require extensive global optimization and it is applicable to a wide range of complex dynamical systems subject to noise.

physics.data-an↗