arXiv subjects

Adalberto Claudio Quiros

Publications and source records attributed to Adalberto Claudio Quiros.

6 recordsLinked to original sources

arXiv2026

VISTA: An Attention-Based Multi-Agent Reinforcement Learning Architecture for Space Situational Awareness Sensor Tasking

The rapid growth of resident space objects is increasing the complexity of space situational awareness sensor tasking, challenging classical optimization methods as they allocate finite, heterogeneous, and distributed sensing resources across ever-larger catalogues. Existing deep reinforcement learning approaches show promise in reduced settings, but fixed-dimensional state and action representations limit their ability to scale to large, dynamic catalogues and distributed sensing networks. We introduce VISTA (Variable-Entity Intelligent Sensor Tasking Architecture), a scalable deep reinforcement learning architecture for persistent uncertainty-driven catalogue maintenance across variable object populations and sensor configurations. VISTA combines physics- and mission-informed top-K retrieval with entity-centric attention, recurrent memory, and pointer-based action decoding, thereby keeping each agent's observation and action spaces independent of catalogue size. We evaluate VISTA across different scenarios, from fixed-size single-sensor benchmarks to large-scale space-based tasking and heterogeneous cooperative sensing. With 30 orbiting targets, VISTA recovers the catalogue 31.2% faster than the fixed-dimensional recurrent baseline. In the large-scale regime, VISTA reduces five-hour uncertainty by 97.5% relative to the strongest classical reference and by 99.3% relative to the recurrent learner. Zero-shot tests up to 20,000 objects reveal near-linear relations between sensing capacity, catalogue size, and recovery horizon. Learned policies also exhibit sensor modality adaptation and generalization to population and initial-uncertainty shifts. Together, these results demonstrate that VISTA provides a scalable framework for adaptive space situational awareness sensor tasking across large, distributed networks of heterogeneous ground- and space-based sensors.

cs.LG↗

arXiv2026

MUL-T: Decoding Spatial Cellular Architecture in Multiplexed Tissue Images

Understanding tissue organisation in multiplexed imaging requires modelling both cellular phenotypes and their spatial context. Existing approaches typically rely on handcrafted features, such as marker intensity statistics or cell-type proportions, which often fail to scale or generalise across cohorts with heterogeneous marker panels. We introduce MUL-T, a lightweight transformer framework that reframes tissue architecture as a masked contextual prediction task over discrete cell tokens. By learning contextualised [CLS] embeddings without task-specific supervision, the model captures higher-order cellular interactions while remaining computationally efficient. We evaluate MUL-T on several clinically relevant downstream tasks, including core-level tumour pattern classification, patient-level grading, PD-L1 positivity prediction, and cross-dataset treatment response prediction. Across tasks, MUL-T consistently outperforms classical feature-based baselines and achieves performance comparable to a foundation ViT model, despite substantially fewer parameters and lower training cost.

cs.AI↗

arXiv2023

Mapping the landscape of histomorphological cancer phenotypes using self-supervised learning on unlabeled, unannotated pathology slides

Definitive cancer diagnosis and management depend upon the extraction of information from microscopy images by pathologists. These images contain complex information requiring time-consuming expert human interpretation that is prone to human bias. Supervised deep learning approaches have proven powerful for classification tasks, but they are inherently limited by the cost and quality of annotations used for training these models. To address this limitation of supervised methods, we developed Histomorphological Phenotype Learning (HPL), a fully blue{self-}supervised methodology that requires no expert labels or annotations and operates via the automatic discovery of discriminatory image features in small image tiles. Tiles are grouped into morphologically similar clusters which constitute a library of histomorphological phenotypes, revealing trajectories from benign to malignant tissue via inflammatory and reactive phenotypes. These clusters have distinct features which can be identified using orthogonal methods, linking histologic, molecular and clinical phenotypes. Applied to lung cancer tissues, we show that they align closely with patient survival, with histopathologically recognised tumor types and growth patterns, and with transcriptomic measures of immunophenotype. We then demonstrate that these properties are maintained in a multi-cancer study. These results show the clusters represent recurrent host responses and modes of tumor growth emerging under natural selection. Code, pre-trained models, learned embeddings, and documentation are available to the community at https://github.com/AdalbertoCq/Histomorphological-Phenotype-Learning

cs.CV↗

arXiv2021

Adversarial learning of cancer tissue representations

Deep learning based analysis of histopathology images shows promise in advancing the understanding of tumor progression, tumor micro-environment, and their underpinning biological processes. So far, these approaches have focused on extracting information associated with annotations. In this work, we ask how much information can be learned from the tissue architecture itself. We present an adversarial learning model to extract feature representations of cancer tissue, without the need for manual annotations. We show that these representations are able to identify a variety of morphological characteristics across three cancer types: Breast, colon, and lung. This is supported by 1) the separation of morphologic characteristics in the latent space; 2) the ability to classify tissue type with logistic regression using latent representations, with an AUC of 0.97 and 85% accuracy, comparable to supervised deep models; 3) the ability to predict the presence of tumor in Whole Slide Images (WSIs) using multiple instance learning (MIL), achieving an AUC of 0.98 and 94% accuracy. Our results show that our model captures distinct phenotypic characteristics of real tissue samples, paving the way for further understanding of tumor progression and tumor micro-environment, and ultimately refining histopathological classification for diagnosis and treatment. The code and pretrained models are available at: https://github.com/AdalbertoCq/Adversarial-learning-of-cancer-tissue-representations

eess.IV↗

arXiv2021

PathologyGAN: Learning deep representations of cancer tissue

Histopathological images of tumors contain abundant information about how tumors grow and how they interact with their micro-environment. Better understanding of tissue phenotypes in these images could reveal novel determinants of pathological processes underlying cancer, and in turn improve diagnosis and treatment options. Advances of Deep learning makes it ideal to achieve those goals, however, its application is limited by the cost of high quality labels from patients data. Unsupervised learning, in particular, deep generative models with representation learning properties provides an alternative path to further understand cancer tissue phenotypes, capturing tissue morphologies. In this paper, we develop a framework which allows GANs to capture key tissue features and uses these characteristics to give structure to its latent space. To this end, we trained our model on two different datasets, an H&E colorectal cancer tissue from the National Center for Tumor diseases (NCT) and an H&E breast cancer tissue from the Netherlands Cancer Institute (NKI) and Vancouver General Hospital (VGH). Composed of 86 slide images and 576 TMAs respectively. We show that our model generates high quality images, with a FID of 16.65 (breast cancer) and 32.05 (colorectal cancer). We further assess the quality of the images with cancer tissue characteristics (e.g. count of cancer, lymphocytes, or stromal cells), using quantitative information to calculate the FID and showing consistent performance of 9.86. Additionally, the latent space of our model shows an interpretable structure and allows semantic vector operations that translate into tissue feature transformations. Furthermore, ratings from two expert pathologists found no significant difference between our generated tissue images from real ones. The code, images, and pretrained models are available at https://github.com/AdalbertoCq/Pathology-GAN

eess.IV↗

arXiv2020

Learning a low dimensional manifold of real cancer tissue with PathologyGAN

Application of deep learning in digital pathology shows promise on improving disease diagnosis and understanding. We present a deep generative model that learns to simulate high-fidelity cancer tissue images while mapping the real images onto an interpretable low dimensional latent space. The key to the model is an encoder trained by a previously developed generative adversarial network, PathologyGAN. We study the latent space using 249K images from two breast cancer cohorts. We find that the latent space encodes morphological characteristics of tissues (e.g. patterns of cancer, lymphocytes, and stromal cells). In addition, the latent space reveals distinctly enriched clusters of tissue architectures in the high-risk patient group.

eess.IV↗