Multi-Tongue Frequency Fractal Dynamics in Hodgkin-Huxley Neurons Induced by Temporal Interference Stimulation
We investigate neuronal excitability in the Hodgkin--Huxley model under temporal interference (TI) stimulation in a previously unexplored Hertz-resonant regime and uncover a striking nonlinear response that we term ``multitongue frequency fractals''. Unlike single-frequency driving, which yields a smooth resonant valley, dual-frequency excitation fragments this response into a hierarchy of sharply modulated tongues whose number and structure grow with observation time, revealing clear self-similar architecture. These features emerge from transitions between non-cascaded and cascaded high-harmonic and subharmonic generation as detuning varies, and are maximised near the intrinsic ionic timescale at $ω\approx 0.2~\mathrm{rad/ms}$. The proliferation of tongues with observation time follows a Farey-mediant hierarchy and is quantitatively consistent with a box-counting-style scaling exponent $D \approx 1.36$. These results demonstrate that TI stimulation can elicit rich, hierarchically organised frequency responses even in classical excitable membranes, revealing fractal organisation in Hodgkin--Huxley dynamics.