arXiv subjects

Adrian Podoleanu

Publications and source records attributed to Adrian Podoleanu.

8 recordsLinked to original sources

arXiv2026

Time-domain optical coherence tomography at 2 $\mu\mathrm{m}$ using GaSb-based broadband superluminescent diode

We report a time-domain optical coherence tomography (TD-OCT) system operating in the 2 $\mu\mathrm{m}$ spectral region, enabled by a GaSb-based superluminescent diode (SLD). The spectrum emitted by the SLD exhibits a full-width half-maximum (FWHM) of $\sim$80 nm centred near 2.1 $\mu\mathrm{m}$. For OCT operation, stable amplified spontaneous emission with low spectral ripple ($<20\%$) is maintained at drive currents below 150 mA. The SLD is fiber coupled and integrated into a fiber-based Michelson interferometer. In the OCT system, the measured coherence envelope yields an axial resolution of approximately 300 $\mu$m in air and enables depth-resolved imaging of scattering paint-based coating samples. In contrast to OCT implementations at 2 $\mu\mathrm{m}$ wavelength region that commonly rely on supercontinuum sources, the use of GaSb-based SLDs offers a compact practical alternative, leveraging the maturity and scalability of electrically driven semiconductor light sources packaged in a standard "butterfly" module. This report represents the first demonstration of TD-OCT imaging at 2 $\mu\mathrm{m}$ using a GaSb-based SLD source and establishes its suitability for compact and scalable mid-IR OCT instrumentation targeting non-biological, low-water-content materials.

physics.optics↗

arXiv2024

Shot-noise limited, 10 MHz swept-source optical coherence tomography for retinal imaging

Akinetic swept-sources are essential for high-speed optical coherence tomography (OCT) imaging. Time-stretched supercontinuum (TSSC) lasers have proven to be efficient for multi-MHz swept-sources. However, lack of low-noise broadband lasers and of large dispersion devices in the water low-absorption band at 1060 nm have limited the biomedical applications of TSSC lasers. In this letter, an approach to tune the wavelength around 1050 nm over 90 nm with low-noise at 10 MHz is presented. This is based on all-normal dispersion (ANDi) supercontinuum dynamics, and employs a long chirped fiber Bragg grating (CFBG) to time-stretch a broadband pulse with a duty cycle of 93 %. Retinal images are demonstrated, with a sensitivity of 84 dB - approaching the shot noise limit. We believe this high-speed low-noise swept-source will greatly promote the development of OCT techniques for biomedical applications.

physics.optics↗

arXiv2023

Temperature Dependence of a Depth-Encoded System for Polarization-Sensitive Optical Coherence Tomography using a PM Fiber

A polarization-sensitive optical coherence tomography (PS-OCT) system is able to not only show the structure of samples through the analysis of backscattered light, but is also capable of determining their polarimetric properties. This is an extra functionality to OCT which allows the retardance and axis orientation of a bulk sample to be determined. Here, we describe the temperature instabilities of a depth-encoded, multiple input state PS-OCT system, where two waves corresponding to two orthogonal states in the interrogating beam are delayed using a 5-meter long polarization-maintaning (PM) fiber. It is shown that the temperature not only affects the delay between the two relatively delayed waves, but also the amount of mismatched dispersion in the interferometer, which ultimately affects the achievable axial resolution in the system. To this end, the technique of complex master/slave interferometry (CMSI) can be used as an option to mitigate this effect.

physics.optics↗

arXiv2021

Endoscopic en-face optical coherence tomography and fluorescence imaging using correlation-based probe tracking

Forward-viewing endoscopic optical coherence tomography (OCT) provides 3D imaging in vivo, and can be combined with widefield fluorescence imaging by use of a double-clad fiber. However, it is technically challenging to build a high-performance miniaturized 2D scanning system with a large field-of-view. In this paper we demonstrate how a 1D scanning probe, which produces cross-sectional OCT images (B-scans) and 1D fluorescence T-scans, can be transformed into a 2D scanning probe by manual scanning along the second axis. OCT volumes are assembled from the B-scans using speckle decorrelation measurements to estimate the out-of-plane motion along the manual scan direction. Motion within the plane of the B-scans is corrected using image registration by normalized cross correlation. En-face OCT slices and fluorescence images, corrected for probe motion in 3D, can be displayed in real-time during the scan. For a B-scan frame rate of 250 Hz, and an OCT lateral resolution of approximately 20 micrometers, the approach can handle out-of-plane motion at speeds of up to 4 mm/s.

physics.optics↗

arXiv2018

Real-time High-Resolution Mid-infrared Optical Coherence Tomography

The potential for improving the penetration depth of optical coherence tomography systems by using increasingly longer wavelength light sources has been known since the inception of the technique in the early 1990s. Nevertheless, the development of mid-infrared optical coherence tomography has long been challenged by the maturity and fidelity of optical components in this spectral region, resulting in slow acquisition, low sensitivity, and poor axial resolution. In this work, a mid-infrared spectral-domain optical coherence tomography system operating at 4 micron central wavelength with an axial resolution of 8.6 microns is demonstrated. The system produces 2D cross-sectional images in real-time enabled by a high-brightness 0.9-4.7 micron mid-infrared supercontinuum source with 1 MHz pulse repetition rate for illumination and broadband upconversion of more than 1 micron bandwidth from 3.58-4.63 microns to 820-865 nm, where a standard 800 nm spectrometer can be used for fast detection. Images produced by the mid-infrared system are compared with those delivered by a state-of-the-art ultra-high-resolution near-infrared optical coherence tomography system operating at 1.3 {\mu}m, and the potential applications and samples suited for this technology are discussed. In doing so, the first practical mid-infrared optical coherence tomography system is demonstrated, with immediate applications in real-time non-destructive testing for the inspection of defects and thickness measurements in samples that are too highly scattering at shorter wavelengths.

physics.optics↗

arXiv2018

All-depth dispersion cancellation in spectral domain optical coherence tomography using numerical intensity correlations

In ultra-high resolution (UHR-) optical coherence tomography (OCT) group velocity dispersion (GVD) must be corrected for in order to approach the theoretical resolution limit. One approach promises not only compensation, but complete annihilation of even order dispersion effects, and that at all sample depths. This approach has hitherto been demonstrated with an experimentally demanding 'balanced detection' configuration based on using two detectors. We demonstrate intensity correlation (IC) OCT using a conventional spectral domain (SD) UHR-OCT system with a single detector. IC-SD-OCT configurations exhibit cross term ghost images and a reduced axial range, half of that of conventional SD-OCT. We demonstrate that both shortcomings can be removed by applying a novel generic artefact reduction algorithm and using analytic interferograms. We show the superiority of IC-SD-OCT compared to conventional SD-OCT by showing how IC-SD-OCT is able to image spatial structures behind a strongly dispersive silicon wafer. Finally, we question the resolution enhancement of square root 2 that IC-SD-OCT is often believed to have compared to SD-OCT. We show that this is simply the effect of squaring the reflectivity profile as a natural result of processing the product of two intensity spectra instead of a single spectrum.

physics.optics↗

arXiv2018

Two Optical Coherence Tomography Systems detect Topical Gold Nanoparticles in Hair follicles, Sweat Ducts and Measure Epidermis

Optical coherence tomography (OCT) is an established imaging technology for in vivo skin investigation. Topical application of gold nanoshells (GNS) provides contrast enhancement in OCT by generating a strong hyperreflective signal from hair follicles and sweat glands, which are the natural skin openings. This study explores the utility of 150 nm diameter GNS as contrast agent for OCT imaging. GNS was massaged into skin and examined in four skin areas of 11 healthy participants. A commercial OCT system and a prototype with 3 micron resolution (UHR-OCT) were employed to detect potential benefits of increased resolution and variability in intensity generated from GNS. In both OCT-systems GNS enhanced contrast from hair follicles and sweat ducts. Highest average penetration depth of GNS was in armpit 0.64 mm plus/minus 0.17, maximum penetration depth was 1.20 mm in hair follicles and 15-40 microns in sweat ducts. Pixel intensity generated from GNS in hair follicles was significantly higher in UHR-OCT images (p=0.002) and epidermal thickness significantly lower 0.14 vs. 0.16 mm (p=0.027). Hence topical application of GNS increases OCT signals from natural skin openings. GNS may also increase sensitivity in OCT diagnosis of certain skin diseases, which is to be examined in future studies.

physics.med-ph↗

arXiv2018

The value of ultrahigh resolution OCT in dermatology - delineating the dermo-epidermal junction, capillaries in the dermal papillae and vellus hairs

Optical coherence tomography (OCT) imaging of the skin is gaining recognition and is increasingly applied to dermatological research. A key dermatological parameter inferred from an OCT image is the epidermal (Ep) thickness as a thickened Ep can be an indicator of a skin disease. Agreement in the literature on the signal characters of Ep and the subjacent skin layer, the dermis (D), is evident. Ambiguities of the OCT signal interpretation in the literature is however seen for the transition region between the Ep and D, which from histology is known as the dermo-epidermal junction (DEJ); a distinct junction comprised by the lower surface of a single cell layer in epidermis connected to an even thinner basement membrane, attached to the underlying dermis. In this work we investigate the impact of an improved axial and lateral resolution on the applicability of OCT for imaging of the skin. To this goal, OCT images are compared produced by a commercial OCT system and by an in-house built ultrahigh resolution (UHR-) OCT system for dermatology. In 11 healthy volunteers, we investigate the DEJ signal characteristics. We perform a detailed analysis of the dark (low) signal band clearly seen for UHR-OCT in the DEJ region where we, by using a transition function, find the signal transition of axial sub-resolution character, which can be directly attributed to the exact location of DEJ, both in normal (thin/hairy) and glabrous (thick) skin. For selected healthy volunteers, we investigate the dermal papillae and the vellus hairs and identify distinct features that only UHR-OCT can resolve. Differences are seen in tracing hairs of diameter below 20mm, and in imaging the dermal papillae where capillary structures are identified in the hand palm, not previously reported in OCT studies and specifically for glabrous skin not reported in any other in vivo optical imaging studies.

physics.med-ph↗