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Aisha Najera

Publications and source records attributed to Aisha Najera.

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When Models Disagree: Rethinking LLM Evaluation for Public Comment Analysis

Federal agencies are deploying large language models (LLMs) to categorize public comment corpora, where the model's organization of the record shapes what policymakers see and which arguments register. Standard evaluation, anchored on stance accuracy against a small validated set, cannot detect when different models produce materially different categorizations of the same public input. We propose an Interpretive Audit Pipeline that treats multi-model disagreement as diagnostic of interpretive complexity and directs human review toward genuinely ambiguous public input. Analyzing 1,260 public comments on a federal USDA docket across four LLMs, we find that inter-model thematic divergence exceeds within-model prompt variation, and that an expert rubric suppresses deep interpretive disagreement without resolving it. In a two-stage labeling study on a stratified 40-comment subsample, four LLMs and a human annotator labeled independently and then revised after seeing the others' labels. Revision behavior varied across labelers, and the human annotator's revisions frequently introduced framings absent from the ensemble's collective output. We argue disagreement-based evaluation is a necessary complement to accuracy metrics for LLM-assisted interpretive coding.

cs.AI

Swallowing a cellular automaton pill: predicting drug release from a matrix tablet

Matrix tablets are drug delivery devices designed to release a drug in a controlled manner over an extended period of time. We develop a cellular automaton (CA) model for the dissolution and release of a water-soluble drug and excipient from a matrix tablet of water-insoluble polymer. Cells of the CA are occupied by drug, excipient, water or polymer and the CA updating rules simulate the dissolution of drug and excipient and the subsequent diffusion of the dissolved substances. In addition we simulate the possible fracture of brittle drug and excipient powders during the tablet compression and the melting of the polymer during a possible thermal curing process. Different stirring mechanisms that facilitate the transport of dissolved drug in the fluid in which the tablet is immersed are modeled in the water cells adjacent to the boundary of the tablet. We find that our simulations can reproduce experimental drug release profiles. Our simulation tool can be used to streamline the formulation and production of sustained release tablets.

physics.med-ph