arXiv subjects

Alain Goriely

Publications and source records attributed to Alain Goriely.

At least 55 records · Page 3Linked to original sources

arXiv2020

A plate theory for nematic liquid crystalline solids

We derive a Föppl-von Kármán-type constitutive model for solid liquid crystalline plates where the nematic director may or may not rotate freely relative to the elastic network. To obtain the reduced two-dimensional model, we rely on the deformation decomposition of a nematic solid into an elastic deformation and a natural shape change. The full solution to the resulting equilibrium equations consists of both the deformation displacement and stress fields. The model equations are applicable to a wide range of thin nematic bodies subject to optothermal stimuli and mechanical loads. For illustration, we consider certain reversible natural shape changes in simple systems which are stress free, and their counterparts, where the natural deformations are blocked and internal stresses appear. More general problems can be addressed within the same framework.

cond-mat.soft↗

arXiv2020

Anisotropic Diffusion and Traveling Waves of Toxic Proteins in Neurodegenerative Diseases

Neurodegenerative diseases are closely associated with the amplification and invasion of toxic proteins. In particular Alzheimer's disease is characterized by the systematic progression of amyloid-$β$ and $τ$-proteins in the brain. These two protein families are coupled and it is believed that their joint presence greatly enhances the resulting damage. Here, we examine a class of coupled chemical kinetics models of healthy and toxic proteins in two spatial dimensions. The anisotropic diffusion expected to take place within the brain along axonal pathways is factored in the models and produces a filamentary, predominantly one-dimensional transmission. Nevertheless, the potential of the anisotropic models towards generating interactions taking advantage of the two-dimensional landscape is showcased. Finally, a reduction of the models into a simpler family of generalized Fisher-Kolmogorov-Petrovskii-Piskunov (FKPP) type systems is examined. It is seen that the latter captures well the qualitative propagation features, although it may somewhat underestimate the concentrations of the toxic proteins.

q-bio.CB↗

arXiv2020

Dynamic buckling of an inextensible elastic ring: Linear and nonlinear analyses

Slender elastic objects such as a column tend to buckle under loads. While static buckling is well understood as a bifurcation problem, the evolution of shapes during dynamic buckling is much harder to study. Elastic rings under normal pressure have emerged as a theoretical and experimental paradigm for the study of dynamic buckling with controlled loads. Experimentally, an elastic ring is placed within a soap film. When the film outside the ring is removed, surface tension pulls the ring inward, mimicking an external pressurization. Here we present a theoretical analysis of this process by performing a post-bifurcation analysis of an elastic ring under pressure. This analysis allows us to understand how inertia, material properties, and loading affect the observed shape. In particular, we combine direct numerical solutions with a post-bifurcation asymptotic analysis to show that inertia drives the system towards higher modes that cannot be selected in static buckling. Our theoretical results explain experimental observations that cannot be captured by a standard linear stability analysis.

cond-mat.soft↗

arXiv2020

Dynamic buckling of elastic rings in a soap film

Dynamic buckling may occur when a load is rapidly applied to, or removed from, an elastic object at rest. In contrast to its static counterpart, dynamic buckling offers a wide range of accessible patterns depending on the parameters of the system and the dynamics of the load. To study these effects, we consider experimentally the dynamics of an elastic ring in a soap film when part of the film is suddenly removed. The resulting change in tension applied to the ring creates a range of interesting patterns that cannot be easily accessed in static experiments. Depending on the aspect ratio of the ring's cross section, high-mode buckling patterns are found in the plane of the remaining soap film or out of the plane. Paradoxically, while inertia is required to observe these non-trivial modes, the selected pattern does not depend on inertia itself. The evolution of this pattern beyond the initial instability is studied experimentally and explained through theoretical arguments linking dynamics to pattern selection and mode growth. We also explore the influence of dynamic loading and show numerically that by imposing a rate of loading that competes with the growth rate of instability, the observed pattern can be selected and controlled.

cond-mat.soft↗

arXiv2020

Likely striping in stochastic nematic elastomers

For monodomain nematic elastomers, we construct generalised elastic-nematic constitutive models combining purely elastic and neoclassical-type strain-energy densities. Inspired by recent developments in stochastic elasticity, we extend these models to stochastic-elastic-nematic forms where the model parameters are defined by spatially-independent probability density functions at a continuum level. To investigate the behaviour of these systems and demonstrate the effects of the probabilistic parameters, we focus on the classical problem of shear striping in a stretched nematic elastomer for which the solution is given explicitly. We find that, unlike in the neoclassical case where the inhomogeneous deformation occurs within a universal interval that is independent of the elastic modulus, for the elastic-nematic models, the critical interval depends on the material parameters. For the stochastic extension, the bounds of this interval are probabilistic, and the homogeneous and inhomogeneous states compete in the sense that both have a a given probability to occur. We refer to the inhomogeneous pattern within this interval as "likely striping".

cond-mat.soft↗

arXiv2020

Likely cavitation and radial motion of stochastic elastic spheres

The cavitation of solid elastic spheres is a classical problem of continuum mechanics. Here, we study this problem within the context of "stochastic elasticity" where the constitutive parameters are characterised by probability density functions. We consider homogeneous spheres of stochastic neo-Hookean material, composites with two concentric stochastic neo-Hookean phases, and inhomogeneous spheres of locally neo-Hookean material with a radially varying parameter. In all cases, we show that the material at the centre determines the critical load at which a spherical cavity forms there. However, while under dead-load traction, a supercritical bifurcation, with stable cavitation, is obtained in a static sphere of stochastic neo-Hookean material, for the composite and radially inhomogeneous spheres, a subcritical bifurcation, with snap cavitation, is also possible. For the dynamic spheres, oscillatory motions are produced under suitable dead-load traction, such that a cavity forms and expands to a maximum radius, then collapses again to zero periodically, but not under impulse traction. Under a surface impulse, a subcritical bifurcation is found in a static sphere of stochastic neo-Hookean material and also in an inhomogeneous sphere, whereas in composite spheres, supercritical bifurcations can occur as well. Given the non-deterministic material parameters, the results can be characterised in terms of probability distributions.

physics.class-ph↗

arXiv2020

Likely cavitation and radial motion of stochastic elastic spheres 2: Impulse driven

Cavitation in solids can be caused by tensile dead-load traction or impulse traction. The two different types of boundary conditions lead to different static and dynamic solutions. In addition, if the material is stochastic, i.e., the model parameters are represented by probability distributions, the expected behaviour is more complicated to describe. Here, following the first instalment of this work, we examine the static and dynamic cavitation of a stochastic material under a uniform tensile impulse traction in different spherical geometries. We find that the critical load at which a cavity forms at the centre of the sphere is the same as for the homogeneous sphere composed entirely of the material found at its centre, while the post-cavitation radial motion is non-oscillatory. However, there are some important differences in the nonlinear elastic responses. Specifically, subcritical bifurcation, with snap cavitation, is obtained in a static sphere of stochastic neo-Hookean material and also in a radially inhomogeneous sphere, whereas for composite spheres, a supercritical bifurcation, with stable cavitation, is possible as well. Given the non-deterministic material parameters, the results are characterised by probability distributions.

physics.class-ph↗

arXiv2020

The role of topology and mechanics in uniaxially growing cell networks

In biological systems, the growth of cells, tissues, and organs is influenced by mechanical cues. Locally, cell growth leads to a mechanically heterogeneous environment as cells pull and push their neighbors in a cell network. Despite this local heterogeneity, at the tissue level, the cell network is remarkably robust, as it is not easily perturbed by changes in the mechanical environment or the network connectivity. Through a network model, we relate global tissue structure (i.e. the cell network topology) and local growth mechanisms (growth laws) to the overall tissue response. Within this framework, we investigate the two main mechanical growth laws that have been proposed: stress-driven or strain-driven growth. We show that in order to create a robust and stable tissue environment, networks with predominantly series connections are naturally driven by stress-driven growth, whereas networks with predominantly parallel connections are associated with strain-driven growth.

physics.bio-ph↗

arXiv2019

Likely cavitation in stochastic elasticity

We revisit the classic problem of elastic cavitation within the framework of stochastic elasticity. For the deterministic elastic problem, involving homogeneous isotropic incompressible hyperelastic spheres under radially symmetric tension, there is a critical dead-load traction at which cavitation can occur for some materials. In addition to the well-known case of stable cavitation post-bifurcation at the critical dead load, we show the existence of unstable snap cavitation for some isotropic materials satisfying Baker-Ericksen inequalities. For the stochastic problem, we derive the probability distribution of the deformations after bifurcation. In this case, we find that, due to the probabilistic nature of the material parameters, there is always a competition between the stable and unstable states. Therefore, at a critical load, stable or unstable cavitation occurs with a given probability, and there is also a probability that the cavity may form under smaller or greater loads than the expected critical value. We refer to these phenomena as `likely cavitation'. Moreover, we provide examples of homogeneous isotropic incompressible materials exhibiting stable or unstable cavitation together with their stochastic equivalent.

cond-mat.soft↗

arXiv2019

Likely oscillatory motions of stochastic hyperelastic solids

Stochastic homogeneous hyperelastic solids are characterised by strain-energy densities where the parameters are random variables defined by probability density functions. These models allow for the propagation of uncertainties from input data to output quantities of interest. To investigate the effect of probabilistic parameters on predicted mechanical responses, we study radial oscillations of cylindrical and spherical shells of stochastic incompressible isotropic hyperelastic material, formulated as quasi-equilibrated motions where the system is in equilibrium at every time instant. Additionally, we study finite shear oscillations of a cuboid, which are not quasi-equilibrated. We find that, for hyperelastic bodies of stochastic neo-Hookean or Mooney-Rivlin material, the amplitude and period of the oscillations follow probability distributions that can be characterised. Further, for cylindrical tubes and spherical shells, when an impulse surface traction is applied, there is a parameter interval where the oscillatory and non-oscillatory motions compete, in the sense that both have a chance to occur with a given probability. We refer to the dynamic evolution of these elastic systems, which exhibit inherent uncertainties due to the material properties, as `likely oscillatory motions'.

physics.class-ph↗

arXiv2019

Likely equilibria of stochastic hyperelastic spherical shells and tubes

In large deformations, internally pressurised elastic spherical shells and tubes may undergo a limit-point, or inflation, instability manifested by a rapid transition in which their radii suddenly increase. The possible existence of such an instability depends on the material constitutive model. Here, we revisit this problem in the context of stochastic incompressible hyperelastic materials, and ask the question: what is the probability distribution of stable radially symmetric inflation, such that the internal pressure always increases as the radial stretch increases? For the classic elastic problem, involving isotropic incompressible materials, there is a critical parameter value that strictly separates the cases where inflation instability can occur or not. By contrast, for the stochastic problem, we show that the inherent variability of the probabilistic parameters implies that there is always competition between the two cases. To illustrate this, we draw on published experimental data for rubber, and derive the probability distribution of the corresponding random shear modulus to predict the inflation responses for a spherical shell and a cylindrical tube made of a material characterised by this parameter.

cond-mat.soft↗

arXiv2019

A computational framework for the morpho-elastic development of molluskan shells by surface and volume growth

Mollusk shells are an ideal model system for understanding the morpho-elastic basis of morphological evolution of invertebrates' exoskeletons. During the formation of the shell, the mantle tissue secretes proteins and minerals that calcify to form a new incremental layer of the exoskeleton. Most of the existing literature on the morphology of mollusks is descriptive. The mathematical understanding of the underlying coupling between pre-existing shell morphology, de novo surface deposition and morpho-elastic volume growth is at a nascent stage, primarily limited to reduced geometric representations. Here, we propose a general, three-dimensional computational framework coupling pre-existing morphology, incremental surface growth by accretion, and morpho-elastic volume growth. We exercise this framework by applying it to explain the stepwise morphogenesis of seashells during growth: new material surfaces are laid down by accretive growth on the mantle whose form is determined by its morpho-elastic growth. Calcification of the newest surfaces extends the shell as well as creates a new scaffold that constrains the next growth step. We study the effects of surface and volumetric growth rates, and of previously deposited shell geometries on the resulting modes of mantle deformation, and therefore of the developing shell's morphology. Connections are made to a range of complex shells ornamentations.

q-bio.QM↗

arXiv2019

Likely chirality of stochastic anisotropic hyperelastic tubes

When an elastic tube reinforced with helical fibres is inflated, its ends rotate. In large deformations, the amount and chirality of rotation is highly non-trivial, as it depends on the choice of strain-energy density and the arrangements of the fibres. For anisotropic hyperelastic tubes where the material parameters are single-valued constants, the problem has been satisfactorily addressed. However, in many systems, the material parameters are not precisely known, and it is therefore more appropriate to treat them as random variables. The problem is then to understand chirality in a probabilistic framework. Here, we develop a procedure for examining the elastic responses of a hyperelastic cylindrical tube of stochastic anisotropic material, where the material parameters are spatially-independent random variables defined by probability density functions. The tube is subjected to uniform dead loading consisting of internal pressure, axial tension and torque. Assuming that the tube wall is thin and that the resulting deformation is the combined inflation, extension and torsion from the reference circular cylindrical configuration to a deformed circular cylindrical state, we derive the probabilities of radial expansion or contraction, and of right-handed or left-handed torsion. We refer to these stochastic behaviours as `likely inflation' and `likely chirality', respectively.

physics.class-ph↗

arXiv2019

Likely equilibria of the stochastic Rivlin cube

The problem of the Rivlin cube is to determine the stability of all homogeneous equilibria of an isotropic incompressible hyperelastic body under equitriaxial dead loads. Here, we consider the stochastic version of this problem where the elastic parameters are random variables following standard probability laws. Uncertainties in these parameters may arise, for example, from inherent data variation between different batches of homogeneous samples, or from different experimental tests. As for the deterministic elastic problem, we consider the following questions: what are the likely equilibria and how does their stability depend on the material constitutive law? In addition, for the stochastic model, the problem is to derive the probability distribution of deformations, given the variability of the parameters.

math-ph↗

arXiv2018

The mechanics of human brain organoids

Organoids are prototypes of human organs derived from cultured human stem cells. They provide a reliable and accurate experimental model to study the physical mechanisms underlying the early developmental stages of human organs morphogenesis and, in particular, the early morphogenesis of the cortex. Here, we propose a mathematical model to elucidate the role played by two mechanisms which have been experimentally proven to be crucial in shaping human brain organoids: the contraction of the inner core of the organoid and the microstructural remodeling of the outer cortex. Our results show that both mechanisms are crucial for the final shape of the organoid and can explain the origin of brain pathologies such as lissencephaly (smooth brain).

cond-mat.soft↗

arXiv2018

Are homeostatic states stable? Dynamical stability in morphoelasticity

Biological growth is often driven by mechanical cues, such as changes in external pressure or tensile loading. Moreover, it is well known that many living tissues actively maintain a preferred level of mechanical internal stress, called the mechanical homeostasis. The tissue-level feedback mechanism by which changes of the local mechanical stresses affect growth is called a growth law within the theory of morphoelasticity, a theory for understanding the coupling between mechanics and geometry in growing and evolving biological materials. The goal of this article is to develop mathematical techniques to analyze growth laws and to explore issues of heterogeneity and growth stability. We discuss the growth dynamics of tubular structures, which are very common in biology (e.g. arteries, plant stems, airways) and model the homeostasis-driven growth dynamics of tubes which produces spatially inhomogeneous residual stress. We show that the stability of the homeostatic state depends nontrivially on the anisotropy of the growth response. The key role of anisotropy may provide a foundation for experimental testing of homeostasis-driven growth laws.

physics.bio-ph↗

arXiv2018

The multiphysics of prion-like diseases: progression and atrophy

Many neurodegenerative diseases are related to the propagation and accumulation of toxic proteins throughout the brain. The lesions created by aggregates of these toxic proteins further lead to cell death and accelerated tissue atrophy. A striking feature of some of these diseases is their characteristic pattern and evolution, leading to well-codified disease stages visible to neuropathology and associated with various cognitive deficits and pathologies. Here, we simulate the anisotropic propagation and accumulation of toxic proteins in full brain geometry. We show that the same model with different initial seeding zones reproduces the characteristic evolution of different prion-like diseases. We also recover the expected evolution of the total toxic protein load. Finally, we couple our transport model to a mechanical atrophy model to obtain the typical degeneration patterns found in neurodegenerative diseases.

q-bio.NC↗

arXiv2016

Guaranteed upper and lower bounds on the uniform load of contact problems in elasticity

Two mathematical models are developed within the theoretical framework of large strain elasticity for the determination of upper and lower bounds on the total strain energy of a finitely deformed hyperelastic body in unilateral contact with a rigid surface or with an elastic substrate. The model problems take the form of two continuous optimization problems with inequality constraints, the solutions of which are used to provide an enclosure on the uniform external load acting on the body's surface away from the contact zone.

math.AP↗