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Alberto Boffi

Publications and source records attributed to Alberto Boffi.

3 recordsLinked to original sources

VirtualRelativity: An Interactive Simulation of the Special Theory of Relativity in Virtual Reality

The Special Theory of Relativity, introduced by Albert Einstein in the early 20th century, marked a radical shift in our understanding of space and time. Nevertheless, the theory's non-intuitive implications continue to pose conceptual challenges for novice physicists. In this thesis, we propose a virtual reality solution based on the development of a Unity package capable of simulating the effects of relativity in a digital environment. The current implementation includes the representation of space contraction, time dilation and relativistic Doppler effect. The primary focus lies in the accurate representation of relativistic laws, as well as in computational efficiency and in the modeling of a user interface specifically crafted to enhance understanding and interactivity. The package significantly reduces developer workload through a streamlined API, enabling maximum freedom in the development of virtual scenarios. Design goals are validated by a testing phase conducted through dedicated probe scenes. To showcase the potential of this work, we also present the deployment of a VR application built on top of the package, that transports users in experiencing relativistic effects in real-life scenarios. The application is scheduled to be used by Master's students in Physical Engineering at Politecnico di Milano. In the meanwhile, other educational areas of expansion are being considered, suggesting a promising future in the direction of this work.

physics.ed-ph

An efficient way to manage ranges of data with Wise Red-Black Trees

This paper describes the most efficient way to manage operations on ranges of elements within an ordered set. The goal is to improve existing solutions, by optimizing the average-case time complexity and getting rid of heavy multiplicative constants in the worst-case, without sacrificing space complexity. This is a high-impact operation in practical applications, performed by introducing a new data structure called Wise Red-Black Tree, an augmented version of the Red-Black Tree.

cs.DS

Molecular mechanisms behind anti SARS-CoV-2 action of lactoferrin

Despite the huge effort to contain the infection, the novel SARS-CoV-2 coronavirus has rapidly become pandemics, mainly due to its extremely high human-to-human transmission capability, and a surprisingly high viral charge of symptom-less people. While the seek of a vaccine is still ongoing, promising results have been obtained with antiviral compounds. In particular, lactoferrin is found to have beneficial effects both in preventing and soothing the infection. Here, we explore the possible molecular mechanisms with which lactoferrin interferes with SARS-CoV-2 cell invasion, preventing attachment and/or entry of the virus. To this aim, we search for possible interactions lactoferrin may have with virus structural proteins and host receptors. Representing the molecular iso-electron surface of proteins in terms of 2D-Zernike descriptors, we (i) identified putative regions on the lactoferrin surface able to bind sialic acid receptors on the host cell membrane, sheltering the cell from the virus attachment; (ii) showed that no significant shape complementarity is present between lactoferrin and the ACE2 receptor, while (iii) two high complementarity regions are found on the N- and C-terminal domains of the SARS-CoV-2 spike protein, hinting at a possible competition between lactoferrin and ACE2 for the binding to the spike protein.

q-bio.BM