arXiv subjects

Aleksandar Marinkovic

Publications and source records attributed to Aleksandar Marinkovic.

2 recordsLinked to original sources

arXiv2026

Head Coil-Mounted Vision Correction Device for Magnetic Resonance Imaging

Correction for nearsightedness and farsightedness is an important concern for functional magnetic resonance imaging (fMRI) experiments involving visual stimuli in humans. In the absence of personal contact lenses, spherical refractive errors are typically corrected using interchangeable lenses mounted in goggles or glasses frames worn by the participant, or mounted on the head coil during scanning. The coil-mounted device described here avoids the ergonomic challenges encountered with head-mounted goggles and addresses limitations of prior coil-mounted designs, including ease of lens switching and inter-pupillary distance adjustments. Our device can be 3D printed economically with MRI-compatible plastics, including PLA.

physics.med-ph↗

arXiv2014

High-throughput screening for modulators of cellular contractile force

When cellular contractile forces are central to pathophysiology, these forces comprise a logical target of therapy. Nevertheless, existing high-throughput screens are limited to upstream signaling intermediates with poorly defined relationship to such a physiological endpoint. Using cellular force as the target, here we screened libraries to identify novel drug candidates in the case of human airway smooth muscle cells in the context of asthma, and also in the case of Schlemm's canal endothelial cells in the context of glaucoma. This approach identified several drug candidates for both asthma and glaucoma. We attained rates of 1000 compounds per screening day, thus establishing a force-based cellular platform for high-throughput drug discovery.

physics.bio-ph↗