SearcharxivSearch

arXiv subjects

Alessandra Andreoni

Publications and source records attributed to Alessandra Andreoni.

16 recordsLinked to original sources

Polymorphic gene conferring susceptibility to insulin-dependent diabetes mellitus typed by ps-resolved FRET on nonamplified genomic DNA

This work concerns the identification of the allelic sequences of the DQB1 gene of the human leukocyte antigen system conferring susceptibility to the development of insulin-dependent diabetes mellitus (IDDM) in DNA samples with no need of PCR amplification. Our method is based on the time-resolved analysis of a Förster energy-transfer mechanism that occurs in a dual-labeled fluorescent probe specific for the base sequence of the allelic variant of interest. Such an oligonucleotide probe is labeled, at the two ends, by a pair of chromophores that operate as donor and acceptor in a Förster resonant energy-transfer. The donor fluorescence is quenched with an efficiency that is strongly dependent on the donor-to-acceptor distance, hence on the configuration of the probe after hybridization with the DNA containing or not the selected allelic sequence. By time-correlated single-photon counting, performed with an excitation/detection system endowed with 30-ps resolution, we measure the time-resolved fluorescence decay of the donor and discriminate, by means of the decay time value, the DNA bearing the allele conferring susceptibility to IDDM from the DNAs bearing any other sequence in the same region of the DQB1 gene.

q-bio.GN

Photon-number correlations by photon-number resolving detectors

We demonstrate that by using a pair of photodetectors endowed with internal gain we are able to quantify the correlation coefficient between the two components of a pulsed bipartite state in the mesoscopic intensity regime (less than 100 mean photons).

quant-ph

Photon-number statistics with Silicon photomultipliers

We present a description of the operation of a multi-pixel detector in the presence of non-negligible dark-count and cross-talk effects. We apply the model to devise self-consistent calibration strategies to be performed on the very light under investigation.

quant-ph

Self-consistent phase determination for Wigner function reconstruction

We present the reconstruction of the Wigner function of a classical phase-sensitive state, a pulsed coherent state, by measurements of the distributions of detected-photons of the state displaced by a coherent probe field. By using a hybrid photodetector operated above its photon-resolving regime, we obtained both the statistics at different values of the probe field and the values of the probe phase required to reconstruct the Wigner function.

quant-ph

Photon statistics in the macroscopic realm measured without photon-counters

In a macroscopic realm, in which photons are too many for being counted by any photon counting detector, photon statistics can be measured by using detectors simply endowed with linear response. We insert one of such detectors in a conventional photon-counting apparatus, which returns a voltage every time the detector responds to light by generating a number of elementary charges via its primary photo-detection process. We only assume that, when a single charge is photo-generated, the probability density of the voltages is a distribution that is narrow with respect to its mean value. Under this hypothesis the output voltages can be suitably binned so that their probability distribution is the same as that of the photo-generated charges, that is, of the detected photons.

quant-ph

Wigner function of pulsed fields by direct detection

We present the reconstruction of the Wigner function of some classical pulsed optical states obtained by direct measurement of the detected-photon probability distributions of the state displaced by a coherent field. We use a photodetector endowed with internal gain, which is operated in the non- photon-resolving regime. The measurements are performed up to mesoscopic intensities (up to more than 30 photons per pulse). The method can be applied to characterize nonclassical continuous-variable states.

quant-ph

Correlations in photon-numbers and integrated intensities in parametric processes involving three optical fields

Two strongly-pumped parametric interactions are simultaneously realized in a single nonlinear crystal in order to generate three strongly correlated optical fields. By combining together the outputs of two of the three detectors measuring intensities of the generated fields, we obtain the joint photocount statistics between the single field and the sum of the other two. Moreover, we develop a microscopic quantum theory to determine the joint photon-number distribution and the joint quasi-distributions of integrated intensities and prove nonclassical nature of the three-mode state. Finally, by performing a conditional measurement on the single field, we obtain a state endowed with a sub-Poissonian statistics, as testified by the analysis of the conditional Fano factor. The role of quantum detection efficiencies in this conditional state-preparation method is discussed in detail.

quant-ph

The quantum-classical transition in thermally seeded parametric downconversion

We address the pair of conjugated field modes obtained from parametric-downconversion as a convenient system to analyze the quantum-classical transition in the continuous variable regime. We explicitly evaluate intensity correlations, negativity and entanglement for the system in a thermal state and show that a hierarchy of nonclassicality thresholds naturally emerges in terms of thermal and downconversion photon number. We show that the transition from quantum to classical regime may be tuned by controlling the intensities of the seeds and detected by intensity measurements. Besides, we show that the thresholds are not affected by losses, which only modify the amount of nonclassicality. The multimode case is also analyzed in some detail.

quant-ph

Light statistics by non-calibrated linear photodetectors

We theoretically demonstrate that detectors endowed with internal gain and operated in regimes in which they do not necessarily behave as photon-counters, but still ensure linear input/output responses, can allow a self-consistent characterization of the statistics of the number of detected photons without need of knowing their gain. We present experiments performed with a photo-emissive hybrid detector on a number of classical fields endowed with non-trivial statistics and show that the method works for both microscopic and mesoscopic photon numbers. The obtained detected-photon probability distributions agree with those expected for the photon numbers, which are also reconstructed by an independent method.

quant-ph

Self-consistent characterization of light statistics

We demonstrate the possibility of a self-consistent characterization of the photon-number statistics of a light field by using photoemissive detectors with internal gain simply endowed with linear input/output responses. The method can be applied to both microscopic and mesoscopic photon-number regimes. The detectors must operate in the linear range without need of photon-counting capabilities.

quant-ph

Demonstration of a bright and compact source of tripartite nonclassical light

We experimentally demonstrate the nonclassical photon number correlations expected in tripartite continuous variable states obtained by parametric processes. Our scheme involves a single nonlinear crystal, where two interlinked parametric interactions take place simultaneously, and represents a bright and compact source of a sub-shot-noise tripartite light field. We analyze the effects of the pump intensities on the numbers of detected photons and on the amount of noise reduction in some details, thus demonstrating a good agreement between the experimental data and a single-mode theoretical description.

quant-ph

Experimental joint signal-idler quasi-distributions and photon-number statistics for mesoscopic twin beams

Joint signal-idler photoelectron distributions of twin beams containing several tens of photons per mode have been measured recently. Exploiting a microscopic quantum theory for joint quasi-distributions in parametric down-conversion developed earlier we characterize properties of twin beams in terms of quasi-distributions using experimental data. Negative values as well as oscillating behaviour in quantum region are characteristic for the subsequently determined joint signal-idler quasi-distributions of integrated intensities. Also the conditional and difference photon-number distributions are shown to be sub-Poissonian and sub-shot-noise, respectively.

quant-ph

Intensity correlations, entanglement properties and ghost imaging in multimode thermal-seeded parametric downconversion: Theory

We address parametric-downconversion seeded by multimode pseudo-thermal fields. We show that this process may be used to generate multimode pairwise correlated states with entanglement properties that can be tuned by controlling the seed intensities. Multimode pseudo-thermal fields seeded parametric-downconversion represents a novel source of correlated states, which allows one to explore the classical-quantum transition in pairwise correlations and to realize ghost imaging and ghost diffraction in regimes not yet explored by experiments.

quant-ph

Sub-shot-noise photon-number correlation in mesoscopic twin-beam of light

We demonstrate sub-shot-noise photon-number correlations in a (temporal) multimode mesoscopic ($\sim 10^3$ detected photons) twin-beam produced by ps-pulsed spontaneous non-degenerate parametric downconversion. We have separately detected the signal and idler distributions of photons collected in twin coherence areas and found that the variance of the photon-count difference goes below the shot-noise limit by 3.25 dB. The number of temporal modes contained in the twin-beam, as well as the size of the twin coherence areas, depends on the pump intensity. Our scheme is based on spontaneous downconversion and thus does not suffer from limitations due to the finite gain of the parametric process. Twin-beams are also used to demonstrate the conditional preparation of a nonclassical (sub-Poissonian) state.

quant-ph

3D phase-matching conditions for the generation of entangled triplets by chi(2) interlinked interactions

An analytical calculation of the interaction geometry of two interlinked second-order nonlinear processes fulfilling phase-matching conditions is presented. The method is developed for type-I uniaxial crystals and gives the positions on a screen beyond the crystal of the entangled triplets generated by the interactions. The analytical results are compared to experiments realized in the macroscopic regime. Preliminary tests to identify the triplets are also performed based on intensity correlations.

quant-ph

Chaotic imaging in frequency downconversion

We analyze and realize the recovery, by means of spatial intensity correlations, of the image obtained by a seeded frequency downconversion process in which the seed field is chaotic and an intensity modulation is encoded on the pump field. Although the generated field is as chaotic as the seed field and does not carry any information about the modulation of the pump, an image of the pump can be extracted by measuring the spatial intensity correlations between the generated field and one Fourier component of the seed.

quant-ph