arXiv subjects

Alessandro Taloni

Publications and source records attributed to Alessandro Taloni.

28 records · Page 2Linked to original sources

arXiv2014

Mechanical Properties of Growing Melanocytic Nevi and the Progression to Melanoma

Melanocytic nevi are benign proliferations that sometimes turn into malignant melanoma in a way that is still unclear from the biochemical and genetic point of view. Diagnostic and prognostic tools are then mostly based on dermoscopic examination and morphological analysis of histological tissues. To investigate the role of mechanics and geometry in the morpholgical dynamics of melanocytic nevi, we study a computation model for cell proliferation in a layered non-linear elastic tissue. Numerical simulations suggest that the morphology of the nevus is correlated to the initial location of the proliferating cell starting the growth process and to the mechanical properties of the tissue. Our results also support that melanocytes are subject to compressive stresses that fluctuate widely in the nevus and depend on the growth stage. Numerical simulations of cells in the epidermis releasing matrix metalloproteinases display an accelerated invasion of the dermis by destroying the basal membrane. Moreover, we suggest experimentally that osmotic stress and collagen inhibit growth in primary melanoma cells while the effect is much weaker in metastatic cells. Knowing that morphological features of nevi might also reflect geometry and mechanics rather than malignancy could be relevant for diagnostic purposes

q-bio.TO↗

arXiv2013

Generalized Elastic Model: Fractional Langevin Description, Fluctuation Relation, and Linear Response

The Generalized Elastic Model is a linear stochastic model which accounts for the behaviour of many physical systems in nature, ranging from polymeric chains to single-file systems. If an external perturbation is exerted \emph{only} on a single point $\vec{x}^\star$ (\emph{tagged probe}), it propagates throughout the entire system. Within the fractional Langevin equation framework, we study the effect of such a perturbation, in cases of a constant force applied. We report most of the results arising from our previous analysis and, in the present work, we show that the Fox $H$-functions formalism provides a compact, elegant and useful tool for the study of the scaling properties of any observable. In particular we show how the generalized Kubo fluctuation relations can be expressed in terms of $H$-functions.

cond-mat.stat-mech↗

arXiv2013

Stationary growth and unique invariant harmonic measure of cylindrical DLA

We prove that the harmonic measure is stationary, unique and invariant on the interface of DLA growing on a cylinder surface. We provide a detailed theoretical analysis puzzling together multiscaling, multifractality and conformal invariance, supported by extensive numerical simulations of clusters built using conformal mappings and on lattice. The growth properties of the active and frozen zones are clearly elucidated. We show that the unique scaling exponent characterizing the stationary growth is the DLA fractal dimension.

cond-mat.stat-mech↗

arXiv2012

Generalized Elastic Model: thermal vs non-thermal initial conditions. Universal scaling, roughening, ageing and ergodicity

We study correlation properties of the generalized elastic model which accounts for the dynamics of polymers, membranes, surfaces and fluctuating interfaces, among others. We develop a theoretical framework which leads to the emergence of universal scaling laws for systems starting from thermal (equilibrium) or non-thermal (non-equilibrium) initial conditions. Our analysis incorporates and broadens previous results such as observables' double scaling regimes, (super)roughening and anomalous diffusion, and furnishes a new scaling behavior for correlation functions at small times (long distances). We discuss ageing and ergodic properties of the generalized elastic model in non-equilibrium conditions, providing a comparison with the situation occurring in continuous time random walk. Our analysis also allows to assess which observable is able to distinguish whether the system is in or far from equilibrium conditions in an experimental set-up.

cond-mat.stat-mech↗

arXiv2012

Correlations in a Generalized Elastic Model: Fractional Langevin Equation Approach

The Generalized Elastic Model (GEM) provides the evolution equation which governs the stochastic motion of several many-body systems in nature, such as polymers, membranes, growing interfaces. On the other hand a probe (\emph{tracer}) particle in these systems performs a fractional Brownian motion due to the spatial interactions with the other system's components. The tracer's anomalous dynamics can be described by a Fractional Langevin Equation (FLE) with a space-time correlated noise. We demonstrate that the description given in terms of GEM coincides with that furnished by the relative FLE, by showing that the correlation functions of the stochastic field obtained within the FLE framework agree to the corresponding quantities calculated from the GEM. Furthermore we show that the Fox $H$-function formalism appears to be very convenient to describe the correlation properties within the FLE approach.

cond-mat.stat-mech↗

arXiv2012

Unusual Response to a Localized Perturbation in a Generalized Elastic Model

The generalized elastic model encompasses several physical systems such as polymers, membranes, single file systems, fluctuating surfaces and rough interfaces. We consider the case of an applied localized potential, namely an external force acting only on a single (tagged) probe, leaving the rest of the system unaffected. We derive the fractional Langevin equation for the tagged probe, as well as for a generic (untagged) probe, where the force is not directly applied. Within the framework of the fluctuation-dissipation relations, we discuss the unexpected physical scenarios arising when the force is constant and time periodic, whether or not the hydrodynamic interactions are included in the model. For short times, in case of the constant force, we show that the average drift is linear in time for long range hydrodynamic interactions and behaves ballistically or exponentially for local hydrodynamic interactions. Moreover, it can be opposite to the direction of external disturbance for some values of the model's parameters. When the force is time periodic, the effects are macroscopic: the system splits into two distinct spatial regions whose size is proportional to the value of the applied frequency. These two regions are characterized by different amplitudes and phase shifts in the response dynamics.

cond-mat.stat-mech↗

arXiv2012

Generalized Elastic Model yields Fractional Langevin Equation

Starting from a generalized elastic model which accounts for the stochastic motion of several physical systems such as membranes, (semi)flexible polymers and fluctuating interfaces among others, we derive the fractional Langevin equation (FLE) for a probe particle in such systems, in the case of thermal initial conditions. We show that this FLE is the only one fulfilling the fluctuation-dissipation (FD) relation within a new family of fractional Brownian motion (FBM) equations. The FLE for the time-dependent fluctuations of the donor-acceptor distance in a protein, is shown to be recovered. When the system starts from non-thermal conditions, the corresponding FLE, which does not fulfill FD relation, is derived.

cond-mat.stat-mech↗

arXiv2010

Foundation of Fractional Langevin Equation: Harmonization of a Many Body Problem

In this study we derive a single-particle equation of motion, from first-principles, starting out with a microscopic description of a tracer particle in a one-dimensional many-particle system with a general two-body interaction potential. Using a new harmonization technique, we show that the resulting dynamical equation belongs to the class of fractional Langevin equations, a stochastic framework which has been proposed in a large body of works as a means of describing anomalous dynamics. Our work sheds light on the fundamental assumptions of these phenomenological models.

cond-mat.stat-mech↗

arXiv2008

Langevin formulation for single-file diffusion

We introduce a stochastic equation for the microscopic motion of a tagged particle in the single file model. This equation provides a compact representation of several of the system's properties such as Fluctuation-Dissipation and Linear Response relations, achieved by means of a diffusion noise approach. Most important, the proposed Langevin Equation reproduces quantitatively the \emph{three} temporal regimes and the corresponding time scales: ballistic, diffusive and subdiffusive.

cond-mat.stat-mech↗

arXiv2006

Conformal approach to cylindrical DLA

We extend the conformal mapping approach elaborated for the radial Diffusion Limited Aggregation model (DLA) to the cylindrical geometry. We introduce in particular a complex function which allows to grow a cylindrical cluster using as intermediate step a radial aggregate. The grown aggregate exhibits the same self-affine features of the original cylindrical DLA. The specific choice of the transformation allows us to study the relationship between the radial and the cylindrical geometry. In particular the cylindrical aggregate can be seen as a radial aggregate with particles of size increasing with the radius. On the other hand the radial aggregate can be seen as a cylindrical aggregate with particles of size decreasing with the height. This framework, which shifts the point of view from the geometry to the size of the particles, can open the way to more quantitative studies on the relationship between radial and cylindrical DLA.

cond-mat.stat-mech↗