arXiv subjects

Alex Terrasson

Publications and source records attributed to Alex Terrasson.

6 recordsLinked to original sources

arXiv2026

Practical Limits on Integrated Squeezers

Recent experiments have demonstrated the successful generation and detection of moderately squeezed vacuum states with integrated photonics. However, in order to benefit from the reduced noise of highly squeezed light, many different noise sources must be mitigated. Here, we quantify the fundamental limits these noise sources impose on squeezing measurements and find surprising generality across different platforms and designs. We combine these different limitations into a simple model that provides practical guidance for the design and benchmarking of next-generation integrated squeezed-light systems.

quant-ph↗

arXiv2026

Bright Pulsed Squeezed Light for Quantum-Enhanced Precision Microscopy

Squeezed states of light enable enhanced measurement precision by reducing noise below the standard quantum limit. A key application of squeezed light is nonlinear microscopy, where state-of-the-art performance is limited by photodamage and quantum-limited noise. Such microscopes require bright, pulsed light for optimal operation, yet generating and detecting bright pulsed squeezing at high levels remains challenging. In this work, we present an efficient technique to generate high levels of bright picosecond pulsed squeezed light using a $\chi^2$ optical parametric amplification process in a waveguide. We measure $-3.2~\mathrm{dB}$ of bright squeezing with optical power compatible with nonlinear microscopy, as well as $-3.6~\mathrm{dB}$ of vacuum squeezing. Corrected for losses, these squeezing levels correspond to $-15.4^{+2.7}_{-8.7}~\mathrm{dB}$ of squeezing generated in the waveguide. The measured level of bright amplitude pulsed squeezing is to our knowledge the highest reported to date, and will contribute to the broader adoption of quantum-enhanced nonlinear microscopy in biological studies.

quant-ph↗

arXiv2025

Label-free microscope for rheological imaging of cells

Many essential cellular functions depend on the viscoelastic properties of the cytoplasm. While techniques such as optical tweezers and atomic force microscopy can measure these properties, their reliance on localized probes prevents intracellular imaging and perturbs native cellular behaviour. Label-free microscopy offers non-invasive alternatives that are capable of imaging. However, bandwidth limitations often confine these techniques to the assessment of static mechanical properties or to measurements at gigahertz frequencies, which both lie outside the interesting frequency range typically associated with cellular viscoelasticity. Here, we introduce a label-free microscope capable of imaging the viscoelastic properties of cells at frequencies relevant to biology. The microscope measures intracellular viscoelasticity -- twenty times faster than previous label-free approaches -- and does this with diffraction limited resolution. The measurements reveal characteristic viscoelastic features that were previously inaccessible, allowing quantitative rheology of the cellular cytoskeleton. We apply the microscope to live cancer cells. The rheological images produced identify spatial variations in cellular mechanics, allow active and thermal processes to be distinguished pixel-by-pixel, and enable the state of the cell to be visualised over time and in the presence of stress. The microscope is also able to resolve cellular structures that are invisible to regular phase-sensitive imaging, and do this with high contrast. The ability to image both intracellular viscoelasticity and activity offers a powerful tool to advance fundamental cell biology, cancer research, clinical diagnostics, and drug development.

physics.bio-ph↗

arXiv2024

Fast biological imaging with quantum-enhanced Raman microscopy

Stimulated Raman scattering (SRS) microscopy is a powerful label-free imaging technique that probes the vibrational response of chemicals with high specificity and sensitivity. High-power, quantum-enhanced SRS microscopes have been recently demonstrated and applied to polymers and biological samples. Quantum correlations, in the form of squeezed light, enable the microscopes to operate below the shot noise limit, enhancing their performance without increasing the illumination intensity. This addresses the signal-to-noise ratio (SNR) and speed constraints introduced by photodamage in shot noise-limited microscopes. Previous microscopes have either used single-beam squeezing, but with insufficient brightness to reach the optimal ratio of pump-to-Stokes intensity for maximum SNR, or have used twin-beam squeezing and suffered a 3 dB noise penalty. Here we report a quantum-enhanced Raman microscope that uses a bright squeezed single-beam, enabling operation at the optimal efficiency of the SRS process. The increase in brightness leads to multimode effects that degrade the squeezing level, which we partially overcome using spatial filtering. We apply our quantum-enhanced SRS microscope to biological samples, and demonstrate quantum-enhanced multispectral imaging of living cells. The imaging speed of 100x100 pixels in 18 seconds allows the dynamics of cell organelles to be resolved. The SNR achieved is compatible with video rate imaging, with the quantum correlations yielding a 20% improvement in imaging speed compared to shot noise limited operation.

quant-ph↗

arXiv2023

Quantum light microscopy

Much of our progress in understanding microscale biology has been powered by advances in microscopy. For instance, super-resolution microscopes allow the observation of biological structures at near-atomic-scale resolution, while multi-photon microscopes allow imaging deep into tissue. However, biological structures and dynamics still often remain out of reach of existing microscopes, with further advances in signal-to-noise, resolution and speed needed to access them. In many cases, the performance of microscopes is now limited by quantum effects -- such as noise due to the quantisation of light into photons or, for multi-photon microscopes, the low cross-section of multi-photon scattering. These limitations can be overcome by exploiting features of quantum mechanics such as entanglement. Quantum effects can also provide new ways to enhance the performance of microscopes, such as new super-resolution techniques and new techniques to image at difficult to reach wavelengths. This review provides an overview of these various ways in which quantum techniques can improve microscopy, including recent experimental progress. It seeks to provide a realistic picture of what is possible, and what the constraints and opportunities are.

quant-ph↗

arXiv2020

Quantum correlations overcome the photodamage limits of light microscopy

State-of-the-art microscopes use intense lasers that can severely disturb biological processes, function and viability. This introduces hard limits on performance that only quantum photon correlations can overcome. Here we demonstrate this absolute quantum advantage, achieving signal-to-noise beyond the photodamage-free capacity of conventional microscopy. We achieve this in a coherent Raman microscope, which we use to image molecular bonds within a cell with both quantum-enhanced contrast and sub-wavelength resolution. This allows the observation of nanoscale biological structures that would otherwise not be resolved. Coherent Raman microscopes allow highly selective biomolecular finger-printing in unlabelled specimens, but photodamage is a major roadblock for many applications. By showing that this roadblock can be overcome, our work provides a path towards order-of-magnitude improvements in both sensitivity and imaging speed.

physics.optics↗