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Alexandru Solot

Publications and source records attributed to Alexandru Solot.

2 recordsLinked to original sources

Personalized health coaching via coachable health age and counterfactual wearable trajectories

Personalized health coaching requires moving beyond retrospective wearable summaries toward quantitative, actionable behavioral prescriptions. We introduce Coachable Health Age (CHA), an interpretable health-age metric built from modifiable physiological and behavioral signals passively captured by consumer wearables. Across the WEAR-ME (N=2,780), All of Us (N=22,748), and longitudinal Fitbit (N=1,464) cohorts, CHA aligns with established cardiometabolic health constructs and improves prognostic discrimination for incident cardiovascular and metabolic disease beyond age, sex, and body mass index. To enable prospective behavioral optimization, we developed Sensor World Model (SensorWM), an action-conditioned wearable world model pretrained on over 2.2 million person-weeks of longitudinal sensor data from approximately 100,000 participants. SensorWM accurately forecasts multi-week physiological responses to candidate lifestyle changes ($R^2=0.664$), outperforming generic time-series foundation models while preserving downstream clinical signal for diabetes, hypertension, and other health outcomes. Finally, we integrate CHA and SensorWM into an agentic counterfactual coaching system to synthesize personalized 12-week coaching plans. In blinded paired reviews, certified lifestyle coaches preferred counterfactual-grounded plans over plans grounded in wearable history alone for overall quality (71.4%, P < 0.001) and anticipated adherence (71.0%, P < 0.001), and board-certified clinicians judged 99.2% of counterfactual-grounded plans to meet clinical safety criteria (vs. 97.6% of comparison plans). Automated evaluations across the full cohort (N=2,780) also favored counterfactual-grounded plans. By closing the loop between longitudinal tracking, trajectory prediction, and counterfactual coaching, our framework provides a scalable path to systematically improve cardiometabolic health.

q-bio.QM↗

Insulin Resistance Prediction From Wearables and Routine Blood Biomarkers

Insulin resistance, a precursor to type 2 diabetes, is characterized by impaired insulin action in tissues. Current methods for measuring insulin resistance, while effective, are expensive, inaccessible, not widely available and hinder opportunities for early intervention. In this study, we remotely recruited the largest dataset to date across the US to study insulin resistance (N=1,165 participants, with median BMI=28 kg/m2, age=45 years, HbA1c=5.4%), incorporating wearable device time series data and blood biomarkers, including the ground-truth measure of insulin resistance, homeostatic model assessment for insulin resistance (HOMA-IR). We developed deep neural network models to predict insulin resistance based on readily available digital and blood biomarkers. Our results show that our models can predict insulin resistance by combining both wearable data and readily available blood biomarkers better than either of the two data sources separately (R2=0.5, auROC=0.80, Sensitivity=76%, and specificity 84%). The model showed 93% sensitivity and 95% adjusted specificity in obese and sedentary participants, a subpopulation most vulnerable to developing type 2 diabetes and who could benefit most from early intervention. Rigorous evaluation of model performance, including interpretability, and robustness, facilitates generalizability across larger cohorts, which is demonstrated by reproducing the prediction performance on an independent validation cohort (N=72 participants). Additionally, we demonstrated how the predicted insulin resistance can be integrated into a large language model agent to help understand and contextualize HOMA-IR values, facilitating interpretation and safe personalized recommendations. This work offers the potential for early detection of people at risk of type 2 diabetes and thereby facilitate earlier implementation of preventative strategies.

cs.LG↗