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Ali Abou-Hassan

Publications and source records attributed to Ali Abou-Hassan.

3 recordsLinked to original sources

Leveraging Vision-Language Models to Detect Attention in Educational Videos

Educational videos are a cornerstone of remote and blended learning. However, learners' fluctuating attention remains a significant barrier to effective information retention. Prior research has attempted to mitigate this by detecting and reacting to attention loss at runtime using eye tracking. Such detection has been based so far on classical machine learning classifiers trained on engineered features, such as summary statistics over learners' fixations and saccades. These methods have struggled to capture the complex, temporal nature of learner engagement, thus exhibiting moderate prediction performance. In this study, we aim to advance the detection of attention by shifting from standard engineered features to a multimodal foundation models. Using an educational eye-tracking dataset (N = 70), we investigate a novel methodology that utilizes a Vision-Language Model (VLM) to analyze video content directly with superimposed gaze data. This approach aims to leverage the semantic reasoning capabilities of foundation models to contextualize learner focus within the video stream. We evaluate the performance of this VLM-based approach using several prompting strategies with Gemini 3, but ultimately found that none of them could outperform statistical baselines. Our results provide new insights into the limitations of using VLMs for real-time educational diagnostics.

cs.CV↗

Diffusion of a single colloid on the surface of a giant vesicle and a droplet

The study of interactions between biomimetic membranes and micron-sized particles is crucial for understanding various biological processes. Here, we control microparticle spontaneous engulfment by giant lipid vesicles by tuning particle surface charge, exploring regimes from negligible to strong adhesion. We focus our attention on dissipative phenomena at the micron- and nano- scales, occurring when a particle is wrapped by a lipid vesicle bilayer or when the particle diffuses at the lipid-monolayer interface of a droplet. For particles wrapped by membrane bilayers, we highlight the influence of the particle penetration depth and the impact of substructures on particle friction. Our work is complemented by hydrodynamic simulations that take into account the effects of the shape of the membrane wrapping the particle and the water gap separating the lipid bilayer membrane from the particle on translational particle drag. We show, however, that a purely hydrodynamic model is not suitable to describe the friction of a particle diffusing at the interface of an aqueous microdroplet in oil, stabilized by a single lipid layer. In hydrodynamic models, dissipation is solely described by the surface shear viscosity of the interface and the bulk fluid viscosity, but in this partial wetting configuration, an additional source of dissipation is required to account for fluctuations at the contact line. Hence, through experimental and numerical studies, we demonstrate that the dissipation contributions for the two geometries are fundamentally different.

cond-mat.soft↗

Interaction of fibrinogen-magnetic nanoparticle bioconjugates with integrin reconstituted into artificial membranes

Magnetic nanoparticles have a broad spectrum of biomedical applications including cell separation, diagnostics and therapy. One key issue is little explored: how do the engineered nanoparticles interact with blood components after injection? The formation of bioconjugates in the bloodstream and subsequent reactions are potentially toxic due to the ability to induce an immune response. The understanding of the underlying processes is of major relevance to design not only efficient, but also safe nanoparticles for targeted drug delivery applications. In this study, we report on maghemite nanoparticles functionalized with citrate, dextran and polyethylene glycol coatings and their interaction with the clotting protein fibrinogen. Further, we investigate using biophysical tools (e.g. dynamic light scattering, circular dichroism spectroscopy and quartz crystal microbalance) the interaction of the magnetic nanoparticles-fibrinogen bioconjugates with artificial cell membranes as a model system for blood platelets. We found that fibrinogen corona formation provides colloidal stability to maghemite nanoparticles. In addition, bioconjugates of fibrinogen with dextran and citrate coated NPs interact with integrin containing lipid bilayer, especially upon treatment with divalent ions, whereas PEG-coating reveals minor interaction. Our study at the interface of protein-conjugated nanoparticles and artificial cell membranes is essential for engineering safe nanoparticles for drug delivery applications.

physics.bio-ph↗