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Ali Arafa

Publications and source records attributed to Ali Arafa.

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Multi-Agent Off-Policy Deep Reinforcement Learning for Smart Campus Coverage

Deep reinforcement learning (DRL) has recently gained a great attention due to its real-time adaptation and effectiveness in complex optimization problems. This paper investigates the optimal deployment of millimeter-wave (mmWave) base stations (BSs) in a realistic, non-convex campus topology. The optimization problem is NP-hard, due to the non-convex, non-smooth nature of the max-min fairness objective. To overcome these constraints, we formulate the BS placement as a Markov Decision Process (MDP) and systematically benchmark four DRL schemes: a discrete single-agent Deep Q-Network (DQN), a spatially partitioned Multi-Agent DQN, a continuous single-agent Deep Deterministic Policy Gradient (DDPG), and a geographically partitioned multi-agent DDPG framework. Numerical evaluations reveal that the multi-agent DDPG approach substantially outperforms single-agent in dense scenarios. Additionally full coverage is achieved, and a fairness Jain's index of 0.94 is obtained. Finally, the multi-agent demonstrates highly efficient computational convergence of dense scenarios with $400$ users.

cs.LG

Circulating tumor cell detection in cancer patients using in-flow deep learning holography

Circulating tumor cells (CTCs) are cancer cells found in the bloodstream that serve as biomarkers for early cancer detection, prognostication, and disease monitoring. However, CTC detection remains challenging due to low cell abundance and heterogeneity. Digital holographic microscopy (DHM) offers a promising, label-free method for high-throughput CTC identification by capturing superior morphological information compared to traditional imaging methods, while remaining compatible with in-flow data acquisition. We present a streamlined DHM-based system that integrates microfluidic enrichment with deep learning-driven image analysis, supplemented by immunofluorescent profiling, to improve the sensitivity and specificity of CTC enumeration. Specifically, our platform combines inertial microfluidic preprocessing with dual-modality imaging, integrating holography with fluorescence sensing of up to two markers. A deep learning model, trained on a diverse set of healthy blood samples and cancer cell lines, and executed in real-time, provides a morphological confidence on a cell-by-cell basis that may then be combined with immunofluorescence criteria for enumeration. In a pilot study, we demonstrate significantly higher CTC counts in patients with late-stage prostate cancer (n=13) compared to healthy controls (n=8), with a patient-level false positive rate of 1 cell/mL. Notably, nearly two-thirds of identified CTCs were EpCAM-negative but PSMA positive (a prostate specific epithelial marker), suggesting that traditional use of EpCAM as an epithelial marker for CTCs may lead to false negatives. These findings highlight the potential of DHM for applications including but not limited to screening, diagnostics, and precision oncology.

physics.optics