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Almond Stöcker

Publications and source records attributed to Almond Stöcker.

11 recordsLinked to original sources

Additive Density Regression

We present a structured additive regression approach to model conditional densities given scalar covariates, where only samples of the conditional distributions are observed. This links our approach to distributional regression models for scalar data. The model is formulated in a Bayes Hilbert space -- preserving nonnegativity and integration to one under summation and scalar multiplication -- with respect to an arbitrary finite measure. This allows to consider, amongst others, continuous, discrete and mixed densities. Our theoretical results include asymptotic existence, uniqueness, consistency, and asymptotic normality of the penalized maximum likelihood estimator, as well as confidence regions and inference for the (effect) densities. For estimation, we propose to maximize the penalized log-likelihood corresponding to an appropriate multinomial, or equivalently, Poisson regression model, which we show to approximate the original penalized maximum likelihood problem. We apply our framework to a motivating gender economic data set from the German Socio-Economic Panel Study (SOEP), analyzing the distribution of the woman's share in a couple's total labor income given covariate effects for year, place of residence and age of the youngest child. As the income share is a continuous variable having discrete point masses at zero and one for single-earner couples, the corresponding densities are of mixed type.

stat.ME

A Functional Extension of Semi-Structured Networks

Semi-structured networks (SSNs) merge the structures familiar from additive models with deep neural networks, allowing the modeling of interpretable partial feature effects while capturing higher-order non-linearities at the same time. A significant challenge in this integration is maintaining the interpretability of the additive model component. Inspired by large-scale biomechanics datasets, this paper explores extending SSNs to functional data. Existing methods in functional data analysis are promising but often not expressive enough to account for all interactions and non-linearities and do not scale well to large datasets. Although the SSN approach presents a compelling potential solution, its adaptation to functional data remains complex. In this work, we propose a functional SSN method that retains the advantageous properties of classical functional regression approaches while also improving scalability. Our numerical experiments demonstrate that this approach accurately recovers underlying signals, enhances predictive performance, and performs favorably compared to competing methods.

cs.LG

Additive Density-on-Scalar Regression in Bayes Hilbert Spaces with an Application to Gender Economics

Motivated by research on gender identity norms and the distribution of the woman's share in a couple's total labor income, we consider functional additive regression models for probability density functions as responses with scalar covariates. To preserve nonnegativity and integration to one under vector space operations, we formulate the model for densities in a Bayes Hilbert space, which allows to not only consider continuous densities, but also, e.g., discrete or mixed densities. Mixed ones occur in our application, as the woman's income share is a continuous variable having discrete point masses at zero and one for single-earner couples. Estimation is based on a gradient boosting algorithm, allowing for potentially numerous flexible covariate effects and model selection. We develop properties of Bayes Hilbert spaces related to subcompositional coherence, yielding (odds-ratio) interpretation of effect functions and simplified estimation for mixed densities via an orthogonal decomposition. Applying our approach to data from the German Socio-Economic Panel Study (SOEP) shows a more symmetric distribution in East German than in West German couples after reunification and a smaller child penalty comparing couples with and without minor children. These West-East differences become smaller, but are persistent over time.

stat.ME

Regression in quotient metric spaces with a focus on elastic curves

We propose regression models for curve-valued responses in two or more dimensions, where only the image but not the parametrization of the curves is of interest. Examples of such data are handwritten letters, movement paths or outlines of objects. In the square-root-velocity framework, a parametrization invariant distance for curves is obtained as the quotient space metric with respect to the action of re-parametrization, which is by isometries. With this special case in mind, we discuss the generalization of 'linear' regression to quotient metric spaces more generally, before illustrating the usefulness of our approach for curves modulo re-parametrization. We address the issue of sparsely or irregularly sampled curves by using splines for modeling smooth conditional mean curves. We test this model in simulations and apply it to human hippocampal outlines, obtained from Magnetic Resonance Imaging scans. Here we model how the shape of the irregularly sampled hippocampus is related to age, Alzheimer's disease and sex.

stat.ME

Elastic Full Procrustes Analysis of Plane Curves via Hermitian Covariance Smoothing

Determining the mean shape of a collection of curves is not a trivial task, in particular when curves are only irregularly/sparsely sampled at discrete points. We newly propose an elastic full Procrustes mean of shapes of (oriented) plane curves, which are considered equivalence classes of parameterized curves with respect to translation, rotation, scale, and re-parameterization (warping), based on the square-root-velocity (SRV) framework. Identifying the real plane with the complex numbers, we establish a connection to covariance estimation in irregular/sparse functional data analysis. We introduce Hermitian covariance smoothing and show how to employ this extension of existing covariance estimation methods for obtaining an estimator of the (in)elastic full Procrustes mean, also in the sparse case not yet covered by existing (intrinsic) elastic shape means. For this, we provide different groundwork results which are also of independent interest: we characterize (the decomposition of) the covariance structure of rotation-invariant bivariate stochastic processes using complex representations, and we identify sampling schemes that allow for exact observation of derivatives / SRV transforms of sparsely sampled curves. We demonstrate the performance of the approach in a phonetic study on tongue shapes and in different realistic simulation settings, inter alia based on handwriting data.

stat.ME

Functional additive models on manifolds of planar shapes and forms

The "shape" of a planar curve and/or landmark configuration is considered its equivalence class under translation, rotation and scaling, its "form" its equivalence class under translation and rotation while scale is preserved. We extend generalized additive regression to models for such shapes/forms as responses respecting the resulting quotient geometry by employing the squared geodesic distance as loss function and a geodesic response function to map the additive predictor to the shape/form space. For fitting the model, we propose a Riemannian $L_2$-Boosting algorithm well suited for a potentially large number of possibly parameter-intensive model terms, which also yields automated model selection. We provide novel intuitively interpretable visualizations for (even non-linear) covariate effects in the shape/form space via suitable tensor-product factorization. The usefulness of the proposed framework is illustrated in an analysis of 1) astragalus shapes of wild and domesticated sheep and 2) cell forms generated in a biophysical model, as well as 3) in a realistic simulation study with response shapes and forms motivated from a dataset on bottle outlines.

stat.ME

Multivariate Functional Additive Mixed Models

Multivariate functional data can be intrinsically multivariate like movement trajectories in 2D or complementary like precipitation, temperature, and wind speeds over time at a given weather station. We propose a multivariate functional additive mixed model (multiFAMM) and show its application to both data situations using examples from sports science (movement trajectories of snooker players) and phonetic science (acoustic signals and articulation of consonants). The approach includes linear and nonlinear covariate effects and models the dependency structure between the dimensions of the responses using multivariate functional principal component analysis. Multivariate functional random intercepts capture both the auto-correlation within a given function and cross-correlations between the multivariate functional dimensions. They also allow us to model between-function correlations as induced by e.g.\ repeated measurements or crossed study designs. Modeling the dependency structure between the dimensions can generate additional insight into the properties of the multivariate functional process, improves the estimation of random effects, and yields corrected confidence bands for covariate effects. Extensive simulation studies indicate that a multivariate modeling approach is more parsimonious than fitting independent univariate models to the data while maintaining or improving model fit.

stat.ME

Elastic analysis of irregularly or sparsely sampled curves

We provide statistical analysis methods for samples of curves when the image but not the parametrisation of the curves is of interest. A parametrisation invariant analysis can be based on the elastic distance of the curves modulo warping, but existing methods have limitations in common realistic settings where curves are irregularly and potentially sparsely observed. We provide methods and algorithms to approximate the elastic distance for such curves via interpreting them as polygons. Moreover, we propose to use spline curves for modelling smooth or polygonal Fréchet means of open or closed curves with respect to the elastic distance and show identifiability of the spline model modulo warping. We illustrate the use of our methods for elastic mean and distance computation by application to two datasets. The first application clusters sparsely sampled GPS tracks based on the elastic distance and computes smooth means for each cluster to find new paths on Tempelhof field in Berlin. The second classifies irregularly sampled handwritten spirals of Parkinson's patients and controls based on the elastic distance to a mean spiral curve computed using our approach. All developed methods are implemented in the \texttt{R}-package \texttt{elasdics} and evaluated in simulations.

stat.ME

A Bayesian Time-Varying Autoregressive Model for Improved Short- and Long-Term Prediction

Motivated by the application to German interest rates, we propose a timevarying autoregressive model for short and long term prediction of time series that exhibit a temporary non-stationary behavior but are assumed to mean revert in the long run. We use a Bayesian formulation to incorporate prior assumptions on the mean reverting process in the model and thereby regularize predictions in the far future. We use MCMC-based inference by deriving relevant full conditional distributions and employ a Metropolis-Hastings within Gibbs Sampler approach to sample from the posterior (predictive) distribution. In combining data-driven short term predictions with long term distribution assumptions our model is competitive to the existing methods in the short horizon while yielding reasonable predictions in the long run. We apply our model to interest rate data and contrast the forecasting performance to the one of a 2-Additive-Factor Gaussian model as well as to the predictions of a dynamic Nelson-Siegel model.

stat.ME

Boosting Functional Response Models for Location, Scale and Shape with an Application to Bacterial Competition

We extend Generalized Additive Models for Location, Scale, and Shape (GAMLSS) to regression with functional response. This allows us to simultaneously model point-wise mean curves, variances and other distributional parameters of the response in dependence of various scalar and functional covariate effects. In addition, the scope of distributions is extended beyond exponential families. The model is fitted via gradient boosting, which offers inherent model selection and is shown to be suitable for both complex model structures and highly auto-correlated response curves. This enables us to analyze bacterial growth in \textit{Escherichia coli} in a complex interaction scenario, fruitfully extending usual growth models.

stat.ME

Quantifying alternative splicing from paired-end RNA-sequencing data

RNA-sequencing has revolutionized biomedical research and, in particular, our ability to study gene alternative splicing. The problem has important implications for human health, as alternative splicing may be involved in malfunctions at the cellular level and multiple diseases. However, the high-dimensional nature of the data and the existence of experimental biases pose serious data analysis challenges. We find that the standard data summaries used to study alternative splicing are severely limited, as they ignore a substantial amount of valuable information. Current data analysis methods are based on such summaries and are hence suboptimal. Further, they have limited flexibility in accounting for technical biases. We propose novel data summaries and a Bayesian modeling framework that overcome these limitations and determine biases in a nonparametric, highly flexible manner. These summaries adapt naturally to the rapid improvements in sequencing technology. We provide efficient point estimates and uncertainty assessments. The approach allows to study alternative splicing patterns for individual samples and can also be the basis for downstream analyses. We found a severalfold improvement in estimation mean square error compared popular approaches in simulations, and substantially higher consistency between replicates in experimental data. Our findings indicate the need for adjusting the routine summarization and analysis of alternative splicing RNA-seq studies. We provide a software implementation in the R package casper.

stat.AP