arXiv subjects

Alon Loeffler

Publications and source records attributed to Alon Loeffler.

4 recordsLinked to original sources

arXiv2026

Embodied Neurocomputation: A Framework for Interfacing Biological Neural Cultures with Scaled Task-Driven Validation

Biological neural networks (BNNs) have been established as a powerful and adaptive substrate that offer the potential for incredibly energy and data efficient information processing with distinct learning mechanisms. Yet a core challenge to utilizing BNN for neurocomputation is determining the optimal encoding and decoding mechanisms between the traditional silicon computing interface and the living biology. Here, we propose an Embodied Neurocomputation framework as a systems-level approach to this multi-variable optimization encoding/decoding problem. We operationalize this approach through the first large-scale parameter optimization of encoding configurations for a BNN agent performing closed-loop navigation along an odor-style gradient in a simulated grid-world. Despite the relative simplicity of the task, the biological interactions gave rise to a massive multi-combinatorial search space for optimal parameters. By considering how the components of the system are interconnected and parameterized, we evaluated approximately 1,300 parameter combinations, over 4,000 hours of real-time agent-environment interactions, to identify 12 configurations that consistently demonstrated learning across multiple episodes. These configurations achieved significantly higher task performances than optimized silicon-based DQN agents under the same interaction budget. These findings represent an initial step toward robust and scalable goal-oriented learning using BNNs. Our framework establishes a foundation for applying task-driven neurocomputing and supports the development of field-wide benchmarks. In the long term, this work supports the development of hybrid bio-silicon architectures capable of efficient, adaptive and real-time computation, including the potential for robotic control applications.

cs.ET↗

arXiv2026

CL API: Real-Time Closed-Loop Interactions with Biological Neural Networks

Biological neural networks (BNNs) are increasingly explored for their rich dynamics, parallelism, and adaptive behavior. Beyond understanding their function as a scientific endeavour, a key focus has been using these biological systems as a novel computing substrate. However, BNNs can only function as reliable information-processing systems if inputs are delivered in a temporally and structurally consistent manner. In practice, this requires stimulation with precisely controlled structure, microsecond-scale timing, multi-channel synchronization, and the ability to observe and respond to neural activity in real-time. Existing approaches to interacting with BNNs face a fundamental trade-off: they either depend on low-level hardware mechanisms, imposing prohibitive complexity for rapid iteration, or they sacrifice temporal and structural control, undermining consistency and reproducibility - particularly in closed-loop experiments. The Cortical Labs Application Programming Interface (CL API) enables real-time, sub-millisecond closed-loop interactions with BNNs. Taking a contract-based API design approach, the CL API provides users with precise stimulation semantics, transactional admission, deterministic ordering, and explicit synchronization guarantees. This contract is presented through a declarative Python interface, enabling non-expert programmers to express complex stimulation and closed-loop behavior without managing low-level scheduling or hardware details. Ultimately, the CL API provides an accessible and reproducible foundation for real-time experimentation with BNNs, supporting both fundamental biological research and emerging neurocomputing applications.

q-bio.NC↗

arXiv2025

A Computational Perspective on NeuroAI and Synthetic Biological Intelligence

NeuroAI is an emerging field at the intersection of neuroscience and artificial intelligence, where insights from brain function guide the design of intelligent systems. A central area within this field is synthetic biological intelligence (SBI), which combines the adaptive learning properties of biological neural networks with engineered hardware and software. SBI systems provide a platform for modeling neural computation, developing biohybrid architectures, and enabling new forms of embodied intelligence. In this review, we organize the NeuroAI landscape into three interacting domains: hardware, software, and wetware. We outline computational frameworks that integrate biological and non-biological systems and highlight recent advances in organoid intelligence, neuromorphic computing, and neuro-symbolic learning. These developments collectively point toward a new class of systems that compute through interactions between living neural tissue and digital algorithms.

q-bio.NC↗

arXiv2020

Harnessing adaptive dynamics in neuro-memristive nanowire networks for transfer learning

Nanowire networks (NWNs) represent a unique hardware platform for neuromorphic information processing. In addition to exhibiting synapse-like resistive switching memory at their cross-point junctions, their self-assembly confers a neural network-like topology to their electrical circuitry, something that is impossible to achieve through conventional top-down fabrication approaches. In addition to their low power requirements, cost effectiveness and efficient interconnects, neuromorphic NWNs are also fault-tolerant and self-healing. These highly attractive properties can be largely attributed to their complex network connectivity, which enables a rich repertoire of adaptive nonlinear dynamics, including edge-of-chaos criticality. Here, we show how the adaptive dynamics intrinsic to neuromorphic NWNs can be harnessed to achieve transfer learning. We demonstrate this through simulations of a reservoir computing implementation in which NWNs perform the well-known benchmarking task of Mackey-Glass (MG) signal forecasting. First we show how NWNs can predict MG signals with arbitrary degrees of unpredictability (i.e. chaos). We then show that NWNs pre-exposed to a MG signal perform better in forecasting than NWNs without prior experience of an MG signal. This type of transfer learning is enabled by the network's collective memory of previous states. Overall, their adaptive signal processing capabilities make neuromorphic NWNs promising candidates for emerging real-time applications in IoT devices in particular, at the far edge.

cond-mat.dis-nn↗