arXiv subjects

Amandeep Sekhon

Publications and source records attributed to Amandeep Sekhon.

3 recordsLinked to original sources

arXiv2021

Intrinsically Disordered Proteins at the Nano-scale

The human proteome is enriched in proteins that do not fold into a stable 3D structure. These intrinsically disordered proteins (IDPs) spontaneously fluctuate between a large number of configurations in their native form. Remarkably, the disorder does not lead to dysfunction as with denatured folded proteins. In fact, unlike denatured proteins, recent evidences strongly suggest that multiple biological functions stem from such structural plasticity. Here, focusing on the nanoscopic length-scale, we review the latest advances in IDP research and discuss some of the future directions in this highly promising field.

physics.bio-ph↗

arXiv2020

Experimental realization of diffusion with stochastic resetting

Stochastic resetting is prevalent in natural and man-made systems giving rise to a long series of non-equilibrium phenomena. Diffusion with stochastic resetting serves as a paradigmatic model to study these phenomena, but the lack of a well-controlled platform by which this process can be studied experimentally has been a major impediment to research in the field. Here, we report the experimental realization of colloidal particle diffusion and resetting via holographic optical tweezers. We provide the first experimental corroboration of central theoretical results, and go on to measure the energetic cost of resetting in steady-state and first-passage scenarios. In both cases, we show that this cost cannot be made arbitrarily small due to fundamental constraints on realistic resetting protocols. The methods developed herein open the door to future experimental study of resetting phenomena beyond diffusion.

cond-mat.stat-mech↗

arXiv2017

The effect of boundary slippage and nonlinear rheological response on flow of nanoconfined water

The flow of water confined to nanometer-sized pores is central to a wide range of subjects from biology to nanofluidic devices. Despite its importance, a clear picture about nanoscale fluid dynamics is yet to emerge. Here we measured dissipation in less than 20 nm thick water films and it was found to decrease for both wetting and non-wetting confining surfaces. The fitting of Carreau-Yasuda model of shear thinning to our measurements implies that flow is non-Newtonian and for wetting surfaces the no-slip boundary condition is valid. On the contrary, for non-wetting surfaces boundary slippage occurs with slip lengths of the order of few nm. The findings suggest that both, the wettability of the confining surfaces and nonlinear rheological response of water molecules under nano-confinement play a dominant role in transport properties.

cond-mat.soft↗