arXiv subjects

Amin Beheshti

Publications and source records attributed to Amin Beheshti.

At least 19 recordsLinked to original sources

arXiv2026

Harmonised benchmarking of foundation models for single-cell and spatial transcriptomics reveals context-dependent generalisation

Single-cell and spatial foundation models promise transferable biological representations, yet their generality remains largely untested across modalities, biological domains and analytical tasks. We benchmarked six representative models, Nicheformer, CellPLM, scGPT-spatial, GenePT, scELMo and Novae, using a harmonised framework spanning scRNA-seq, spatial transcriptomics and Perturb-seq. We evaluated zero-shot and continually pretrained clustering, supervised annotation, marker-gene concordance and perturbation prediction. Model performance was strongly conditional: expression-trained cell-level transformers best resolved many cell-identity tasks, spatial and graph-aware models better preserved tissue architecture, and language-derived gene embeddings were competitive for selected perturbation-response metrics. No model dominated across tasks, and rankings shifted with modality, preprocessing, tokenisation, biological prior, domain shift and metric choice. This benchmark provides practical guidance for model selection and argues that future models should be judged by biological generalisation, interpretability and perturbation-grounded validity, not by scale or leaderboard performance alone.

q-bio.GN↗

arXiv2026

Agentic Service-Oriented Computing: A Manifesto for the Next Frontier of Service-Oriented Computing

The rapid emergence of LLM-powered autonomous and semi-autonomous agents is reshaping software systems from static, request-response components into goal-directed, adaptive, and tool-using computational actors. As these agents move from isolated cognitive prototypes into complex distributed workflows, they confront challenges that the Service-Oriented Computing community has studied for more than two decades: composition, interoperability, quality of service, lifecycle management, governance, security, and trust. Yet much of today's agentic AI ecosystem is developing these foundations ad hoc, without the engineering rigour required for dependable enterprise and societal deployment. This paper introduces Agentic Service-Oriented Computing (ASOC) as a new research and practice area concerned with engineering agents as services, orchestrating services through autonomous and semi-autonomous agents, and governing ecosystems of agents and services under constraints of trust, cybersecurity, compliance, performance, and accountability. We articulate six foundational principles of ASOC (harness-ability, composability, lifecycle engineering, trustworthiness by design, goal-driven orchestration, and observability/accountability) and organise a five-dimensional research agenda spanning: (i) agentic services foundations and lifecycle engineering; (ii) composition, orchestration, and interoperability; (iii) governance, observability, and accountability; (iv) security, trust, and risk management; and (v) evaluation, certification, and Agentic QoS. We argue that the Services Computing community is especially well positioned to provide the conceptual and engineering spine for this emerging field, transforming agentic AI from fragmented demonstrations into dependable, service-based systems worthy of human and organisational trust.

cs.AI↗

arXiv2026

A Q-learning-based QoS-aware multipath routing protocol in IoMT-based wireless body area network

The Internet of Medical Things (IoMT) enables intelligent healthcare services but faces challenges such as dynamic topology, energy constraints, and diverse QoS requirements. This paper proposes QQMR, a Q-learning-based QoS-aware multipath routing method for WBANs. QQMR classifies data into three priority levels and employs adaptive multi-level queuing and fuzzy C-means clustering to optimize routing decisions. It maintains separate learning policies for each data type and selects primary and backup paths accordingly. Experimental results demonstrate improved packet delivery ratio and significant reductions in delay, routing overhead, and energy consumption compared to existing methods.

cs.NI↗

arXiv2026

Transcriptomic Models for Immunotherapy Response Prediction Show Limited Cross-cohort Generalisability

Immune checkpoint inhibitors (ICIs) have transformed cancer therapy; yet substantial proportion of patients exhibit intrinsic or acquired resistance, making accurate pre-treatment response prediction a critical unmet need. Transcriptomics-based biomarkers derived from bulk and single-cell RNA sequencing (scRNA-seq) offer a promising avenue for capturing tumour-immune interactions, yet the cross-cohort generalisability of existing prediction models remains unclear.We systematically benchmark nine state-of-the-art transcriptomic ICI response predictors, five bulk RNA-seq-based models (COMPASS, IRNet, NetBio, IKCScore, and TNBC-ICI) and four scRNA-seq-based models (PRECISE, DeepGeneX, Tres and scCURE), using publicly available independent datasets unseen during model development. Overall, predictive performance was modest: bulk RNA-seq models performed at or near chance level across most cohorts, while scRNA-seq models showed only marginal improvements. Pathway-level analyses revealed sparse and inconsistent biomarker signals across models. Although scRNA-seq-based predictors converged on immune-related programs such as allograft rejection, bulk RNA-seq-based models exhibited little reproducible overlap. PRECISE and NetBio identified the most coherent immune-related themes, whereas IRNet predominantly captured metabolic pathways weakly aligned with ICI biology. Together, these findings demonstrate the limited cross-cohort robustness and biological consistency of current transcriptomic ICI prediction models, underscoring the need for improved domain adaptation, standardised preprocessing, and biologically grounded model design.

q-bio.GN↗

arXiv2026

Hierarchical Text-Guided Brain Tumor Segmentation via Sub-Region-Aware Prompts

Brain tumor segmentation remains challenging because the three standard sub-regions, i.e., whole tumor (WT), tumor core (TC), and enhancing tumor (ET), often exhibit ambiguous visual boundaries. Integrating radiological description texts with imaging has shown promise. However, most multimodal approaches typically compress a report into a single global text embedding shared across all sub-regions, overlooking their distinct clinical characteristics. We propose TextCSP (text-modulated soft cascade architecture), a hierarchical text-guided framework that builds on the TextBraTS baseline with three novel components: (1) a text-modulated soft cascade decoder that predicts WT->TC->ET in a coarse-to-fine manner consistent with their anatomical containment hierarchy. (2) sub-region-aware prompt tuning, which uses learnable soft prompts with a LoRA-adapted BioBERT encoder to generate specialized text representations tailored for each sub-region; (3) text-semantic channel modulators that convert the aforementioned representations into channel-wise refinement signals, enabling the decoder to emphasize features aligned with clinically described patterns. Experiments on the TextBraTS dataset demonstrate consistent improvements across all sub-regions against state-of-the-art methods by 1.7% and 6% on the main metrics Dice and HD95.

cs.CV↗

arXiv2026

PersoBench: Benchmarking Personalized Response Generation in Large Language Models

While large language models (LLMs) have exhibited impressive conversational capabilities, their proficiency in delivering personalized responses remains unclear. Although recent benchmarks automatically evaluate persona consistency in role-playing contexts using LLM-based judgment, the evaluation of personalization in response generation remains underexplored. To address this gap, we present an automated benchmarking pipeline, PersoBench, to evaluate the personalization ability of LLMs in persona-aware dialogue generation within a zero-shot setting. Our framework employs a structured pipeline comprising speaker-aware annotation, task-specific and context-driven prompt construction, response post-processing, and automated evaluation across multiple dimensions of generation quality. In particular, the pipeline performs text preprocessing and speaker labeling, constructs structured prompts with task instructions and LLM roles, validates response format, and evaluates valid outputs across fluency, personalization, diversity, and coherence. We assess the performance of four open-source and four closed-source LLMs using well-known datasets and a range of explicit metrics. Our findings reveal that while LLMs excel at generating fluent and diverse responses, they are far from satisfactory in delivering personalized and coherent responses, considering both the conversation context and the provided personas.

cs.CL↗

arXiv2026

PersoDPO: Scalable Preference Optimization for Instruction-Adherent, Persona-Grounded Dialogue via Multi-LLM Evaluation

Personalization and contextual coherence are two essential components in building effective persona-grounded dialogue systems. These aspects play a crucial role in enhancing user engagement and ensuring responses are more relevant and consistent with user identity. However, recent studies indicate that open-source large language models (LLMs) continue to struggle to generate responses that are both contextually grounded and aligned with persona cues, despite exhibiting strong general conversational abilities like fluency and naturalness. We present PersoDPO, a scalable preference optimisation framework that uses supervision signals from automatic evaluations of responses generated by both closed-source and open-source LLMs to fine-tune dialogue models. The framework integrates evaluation metrics targeting coherence and personalization, along with a length-format compliance feature to promote instruction adherence. These signals are combined to automatically construct high-quality preference pairs without manual annotation, enabling a scalable and reproducible training pipeline. Experiments on the FoCus dataset show that an open-source language model fine-tuned with the PersoDPO framework consistently outperforms strong open-source baselines and a standard Direct Preference Optimization (DPO) variant across multiple evaluation dimensions.

cs.CL↗

arXiv2026

PersoPilot: An Adaptive AI-Copilot for Transparent Contextualized Persona Classification and Personalized Response Generation

Understanding and classifying user personas is critical for delivering effective personalization. While persona information offers valuable insights, its full potential is realized only when contextualized, linking user characteristics with situational context to enable more precise and meaningful service provision. Existing systems often treat persona and context as separate inputs, limiting their ability to generate nuanced, adaptive interactions. To address this gap, we present PersoPilot, an agentic AI-Copilot that integrates persona understanding with contextual analysis to support both end users and analysts. End users interact through a transparent, explainable chat interface, where they can express preferences in natural language, request recommendations, and receive information tailored to their immediate task. On the analyst side, PersoPilot delivers a transparent, reasoning-powered labeling assistant, integrated with an active learning-driven classification process that adapts over time with new labeled data. This feedback loop enables targeted service recommendations and adaptive personalization, bridging the gap between raw persona data and actionable, context-aware insights. As an adaptable framework, PersoPilot is applicable to a broad range of service personalization scenarios.

cs.HC↗

arXiv2026

Multimodal Visual Surrogate Compression for Alzheimer's Disease Classification

High-dimensional structural MRI (sMRI) images are widely used for Alzheimer's Disease (AD) diagnosis. Most existing methods for sMRI representation learning rely on 3D architectures (e.g., 3D CNNs), slice-wise feature extraction with late aggregation, or apply training-free feature extractions using 2D foundation models (e.g., DINO). However, these three paradigms suffer from high computational cost, loss of cross-slice relations, and limited ability to extract discriminative features, respectively. To address these challenges, we propose Multimodal Visual Surrogate Compression (MVSC). It learns to compress and adapt large 3D sMRI volumes into compact 2D features, termed as visual surrogates, which are better aligned with frozen 2D foundation models to extract powerful representations for final AD classification. MVSC has two key components: a Volume Context Encoder that captures global cross-slice context under textual guidance, and an Adaptive Slice Fusion module that aggregates slice-level information in a text-enhanced, patch-wise manner. Extensive experiments on three large-scale Alzheimer's disease benchmarks demonstrate our MVSC performs favourably on both binary and multi-class classification tasks compared against state-of-the-art methods.

cs.CV↗

arXiv2025

Uncertainty-Aware Dynamic Knowledge Graphs for Reliable Question Answering

Question answering (QA) systems are increasingly deployed across domains. However, their reliability is undermined when retrieved evidence is incomplete, noisy, or uncertain. Existing knowledge graph (KG) based QA frameworks typically represent facts as static and deterministic, failing to capture the evolving nature of information and the uncertainty inherent in reasoning. We present a demonstration of uncertainty-aware dynamic KGs, a framework that combines (i) dynamic construction of evolving KGs, (ii) confidence scoring and uncertainty-aware retrieval, and (iii) an interactive interface for reliable and interpretable QA. Our system highlights how uncertainty modeling can make QA more robust and transparent by enabling users to explore dynamic graphs, inspect confidence-annotated triples, and compare baseline versus confidence-aware answers. The target users of this demo are clinical data scientists and clinicians, and we instantiate the framework in healthcare: constructing personalized KGs from electronic health records, visualizing uncertainty across patient visits, and evaluating its impact on a mortality prediction task. This use case demonstrates the broader promise of uncertainty-aware dynamic KGs for enhancing QA reliability in high-stakes applications.

cs.CL↗

arXiv2025

Tracking the Unstable: Appearance-Guided Motion Modeling for Robust Multi-Object Tracking in UAV-Captured Videos

Multi-object tracking (MOT) aims to track multiple objects while maintaining consistent identities across frames of a given video. In unmanned aerial vehicle (UAV) recorded videos, frequent viewpoint changes and complex UAV-ground relative motion dynamics pose significant challenges, which often lead to unstable affinity measurement and ambiguous association. Existing methods typically model motion and appearance cues separately, overlooking their spatio-temporal interplay and resulting in suboptimal tracking performance. In this work, we propose AMOT, which jointly exploits appearance and motion cues through two key components: an Appearance-Motion Consistency (AMC) matrix and a Motion-aware Track Continuation (MTC) module. Specifically, the AMC matrix computes bi-directional spatial consistency under the guidance of appearance features, enabling more reliable and context-aware identity association. The MTC module complements AMC by reactivating unmatched tracks through appearance-guided predictions that align with Kalman-based predictions, thereby reducing broken trajectories caused by missed detections. Extensive experiments on three UAV benchmarks, including VisDrone2019, UAVDT, and VT-MOT-UAV, demonstrate that our AMOT outperforms current state-of-the-art methods and generalizes well in a plug-and-play and training-free manner.

cs.CV↗

arXiv2025

MTP: Exploring Multimodal Urban Traffic Profiling with Modality Augmentation and Spectrum Fusion

With rapid urbanization in the modern era, traffic signals from various sensors have been playing a significant role in monitoring the states of cities, which provides a strong foundation in ensuring safe travel, reducing traffic congestion and optimizing urban mobility. Most existing methods for traffic signal modeling often rely on the original data modality, i.e., numerical direct readings from the sensors in cities. However, this unimodal approach overlooks the semantic information existing in multimodal heterogeneous urban data in different perspectives, which hinders a comprehensive understanding of traffic signals and limits the accurate prediction of complex traffic dynamics. To address this problem, we propose a novel Multimodal framework, MTP, for urban Traffic Profiling, which learns multimodal features through numeric, visual, and textual perspectives. The three branches drive for a multimodal perspective of urban traffic signal learning in the frequency domain, while the frequency learning strategies delicately refine the information for extraction. Specifically, we first conduct the visual augmentation for the traffic signals, which transforms the original modality into frequency images and periodicity images for visual learning. Also, we augment descriptive texts for the traffic signals based on the specific topic, background information and item description for textual learning. To complement the numeric information, we utilize frequency multilayer perceptrons for learning on the original modality. We design a hierarchical contrastive learning on the three branches to fuse the spectrum of three modalities. Finally, extensive experiments on six real-world datasets demonstrate superior performance compared with the state-of-the-art approaches.

cs.AI↗

arXiv2025

RETTA: Retrieval-Enhanced Test-Time Adaptation for Zero-Shot Video Captioning

Despite the significant progress of fully-supervised video captioning, zero-shot methods remain much less explored. In this paper, we propose a novel zero-shot video captioning framework named Retrieval-Enhanced Test-Time Adaptation (RETTA), which takes advantage of existing pretrained large-scale vision and language models to directly generate captions with test-time adaptation. Specifically, we bridge video and text using four key models: a general video-text retrieval model XCLIP, a general image-text matching model CLIP, a text alignment model AnglE, and a text generation model GPT-2, due to their source-code availability. The main challenge is how to enable the text generation model to be sufficiently aware of the content in a given video so as to generate corresponding captions. To address this problem, we propose using learnable tokens as a communication medium among these four frozen models GPT-2, XCLIP, CLIP, and AnglE. Different from the conventional way that trains these tokens with training data, we propose to learn these tokens with soft targets of the inference data under several carefully crafted loss functions, which enable the tokens to absorb video information catered for GPT-2. This procedure can be efficiently done in just a few iterations (we use 16 iterations in the experiments) and does not require ground truth data. Extensive experimental results on three widely used datasets, MSR-VTT, MSVD, and VATEX, show absolute 5.1%-32.4% improvements in terms of the main metric CIDEr compared to several state-of-the-art zero-shot video captioning methods.

cs.CV↗

arXiv2025

FlowDubber: Movie Dubbing with LLM-based Semantic-aware Learning and Flow Matching based Voice Enhancing

Movie Dubbing aims to convert scripts into speeches that align with the given movie clip in both temporal and emotional aspects while preserving the vocal timbre of a given brief reference audio. Existing methods focus primarily on reducing the word error rate while ignoring the importance of lip-sync and acoustic quality. To address these issues, we propose a large language model (LLM) based flow matching architecture for dubbing, named FlowDubber, which achieves high-quality audio-visual sync and pronunciation by incorporating a large speech language model and dual contrastive aligning while achieving better acoustic quality via the proposed voice-enhanced flow matching than previous works. First, we introduce Qwen2.5 as the backbone of LLM to learn the in-context sequence from movie scripts and reference audio. Then, the proposed semantic-aware learning focuses on capturing LLM semantic knowledge at the phoneme level. Next, dual contrastive aligning (DCA) boosts mutual alignment with lip movement, reducing ambiguities where similar phonemes might be confused. Finally, the proposed Flow-based Voice Enhancing (FVE) improves acoustic quality in two aspects, which introduces an LLM-based acoustics flow matching guidance to strengthen clarity and uses affine style prior to enhance identity when recovering noise into mel-spectrograms via gradient vector field prediction. Extensive experiments demonstrate that our method outperforms several state-of-the-art methods on two primary benchmarks.

cs.MM↗

arXiv2025

ExBigBang: A Dynamic Approach for Explainable Persona Classification through Contextualized Hybrid Transformer Analysis

In user-centric design, persona development plays a vital role in understanding user behaviour, capturing needs, segmenting audiences, and guiding design decisions. However, the growing complexity of user interactions calls for a more contextualized approach to ensure designs align with real user needs. While earlier studies have advanced persona classification by modelling user behaviour, capturing contextual information, especially by integrating textual and tabular data, remains a key challenge. These models also often lack explainability, leaving their predictions difficult to interpret or justify. To address these limitations, we present ExBigBang (Explainable BigBang), a hybrid text-tabular approach that uses transformer-based architectures to model rich contextual features for persona classification. ExBigBang incorporates metadata, domain knowledge, and user profiling to embed deeper context into predictions. Through a cyclical process of user profiling and classification, our approach dynamically updates to reflect evolving user behaviours. Experiments on a benchmark persona classification dataset demonstrate the robustness of our model. An ablation study confirms the benefits of combining text and tabular data, while Explainable AI techniques shed light on the rationale behind the model's predictions.

cs.LG↗

arXiv2025

FedDPG: An Adaptive Yet Efficient Prompt-tuning Approach in Federated Learning Settings

Pre-trained Language Models (PLMs) have demonstrated impressive performance in various NLP tasks. However, traditional fine-tuning methods for leveraging PLMs for downstream tasks entail significant computational overhead. Prompt-tuning has emerged as an efficient alternative that involves prepending a limited number of parameters to the input sequence and only updating them while the PLM's parameters are frozen. However, this technique's prompts remain fixed for all inputs, reducing the model's flexibility. The Federated Learning (FL) technique has gained attention in recent years to address the growing concerns around data privacy. However, challenges such as communication and computation limitations of clients still need to be addressed. To mitigate these challenges, this paper introduces the Federated Dynamic Prompt Generator (FedDPG), which incorporates a dynamic prompt generator network to generate context-aware prompts based on the given input, ensuring flexibility and adaptability while prioritising data privacy in federated learning settings. Our experiments on three NLP benchmark datasets showcase that FedDPG outperforms the state-of-the-art parameter-efficient fine-tuning methods in terms of global model performance, and has significantly reduced the calculation time and the number of parameters to be sent through the FL network.

cs.LG↗

arXiv2025

Adapter-Enhanced Semantic Prompting for Continual Learning

Continual learning (CL) enables models to adapt to evolving data streams. A major challenge of CL is catastrophic forgetting, where new knowledge will overwrite previously acquired knowledge. Traditional methods usually retain the past data for replay or add additional branches in the model to learn new knowledge, which has high memory requirements. In this paper, we propose a novel lightweight CL framework, Adapter-Enhanced Semantic Prompting (AESP), which integrates prompt tuning and adapter techniques. Specifically, we design semantic-guided prompts to enhance the generalization ability of visual features and utilize adapters to efficiently fuse the semantic information, aiming to learn more adaptive features for the continual learning task. Furthermore, to choose the right task prompt for feature adaptation, we have developed a novel matching mechanism for prompt selection. Extensive experiments on three CL datasets demonstrate that our approach achieves favorable performance across multiple metrics, showing its potential for advancing CL.

cs.CV↗

arXiv2025

VITAL: A New Dataset for Benchmarking Pluralistic Alignment in Healthcare

Alignment techniques have become central to ensuring that Large Language Models (LLMs) generate outputs consistent with human values. However, existing alignment paradigms often model an averaged or monolithic preference, failing to account for the diversity of perspectives across cultures, demographics, and communities. This limitation is particularly critical in health-related scenarios, where plurality is essential due to the influence of culture, religion, personal values, and conflicting opinions. Despite progress in pluralistic alignment, no prior work has focused on health, likely due to the unavailability of publicly available datasets. To address this gap, we introduce VITAL, a new benchmark dataset comprising 13.1K value-laden situations and 5.4K multiple-choice questions focused on health, designed to assess and benchmark pluralistic alignment methodologies. Through extensive evaluation of eight LLMs of varying sizes, we demonstrate that existing pluralistic alignment techniques fall short in effectively accommodating diverse healthcare beliefs, underscoring the need for tailored AI alignment in specific domains. This work highlights the limitations of current approaches and lays the groundwork for developing health-specific alignment solutions.

cs.CL↗