arXiv subjects

Ana Beatriz Solana

Publications and source records attributed to Ana Beatriz Solana.

3 recordsLinked to original sources

arXiv2026

Highly accelerated 3D Cartesian MPnRAGE with implicit neural representation reconstruction

MPnRAGE enables multiple inversion contrast images in a single scan, allowing quantitative T1 mapping, tissue nulled contrasts, and standard MPRAGE synthesis. However, current 3D scan times remain clinically impractical, motivating accelerated 3D MPnRAGE. This work provides a highly accelerated Cartesian 3D MPnRAGE sequence with joint implicit neural representation (INR) reconstruction. The sequence uses a tailored view-ordering strategy, flip angle schedule and complementary variable-density Poisson-disk undersampling. Calibration data acquired during otherwise unused delay time are used for sensitivity map estimation and complementary high-frequency sampling. Ten INR-reconstructed inversion images at 1.5 mm$^3$ are evaluated against fully sampled references via retrospective undersampling. Prospectively accelerated 1 mm$^3$ images at R = 20 (5.39 min) demonstrate clinical feasibility. INR reconstruction outperforms subspace and iterative local low rank reconstruction on highly accelerated data. The proposed highly undersampled 3D Cartesian MPnRAGE with INR reconstruction generates multiple high-quality inversion contrasts in substantially reduced scan time. Scan-specific INR reconstruction improves image quality while reducing reconstruction time versus state-of-the-art methods.

eess.IV↗

arXiv2025

Learning to reason about rare diseases through retrieval-augmented agents

Rare diseases represent the long tail of medical imaging, where AI models often fail due to the scarcity of representative training data. In clinical workflows, radiologists frequently consult case reports and literature when confronted with unfamiliar findings. Following this line of reasoning, we introduce RADAR, Retrieval Augmented Diagnostic Reasoning Agents, an agentic system for rare disease detection in brain MRI. Our approach uses AI agents with access to external medical knowledge by embedding both case reports and literature using sentence transformers and indexing them with FAISS to enable efficient similarity search. The agent retrieves clinically relevant evidence to guide diagnostic decision making on unseen diseases, without the need of additional training. Designed as a model-agnostic reasoning module, RADAR can be seamlessly integrated with diverse large language models, consistently improving their rare pathology recognition and interpretability. On the NOVA dataset comprising 280 distinct rare diseases, RADAR achieves up to a 10.2% performance gain, with the strongest improvements observed for open source models such as DeepSeek. Beyond accuracy, the retrieved examples provide interpretable, literature grounded explanations, highlighting retrieval-augmented reasoning as a powerful paradigm for low-prevalence conditions in medical imaging.

cs.CL↗

arXiv2025

INR meets Multi-Contrast MRI Reconstruction

Multi-contrast MRI sequences allow for the acquisition of images with varying tissue contrast within a single scan. The resulting multi-contrast images can be used to extract quantitative information on tissue microstructure. To make such multi-contrast sequences feasible for clinical routine, the usually very long scan times need to be shortened e.g. through undersampling in k-space. However, this comes with challenges for the reconstruction. In general, advanced reconstruction techniques such as compressed sensing or deep learning-based approaches can enable the acquisition of high-quality images despite the acceleration. In this work, we leverage redundant anatomical information of multi-contrast sequences to achieve even higher acceleration rates. We use undersampling patterns that capture the contrast information located at the k-space center, while performing complementary undersampling across contrasts for high frequencies. To reconstruct this highly sparse k-space data, we propose an implicit neural representation (INR) network that is ideal for using the complementary information acquired across contrasts as it jointly reconstructs all contrast images. We demonstrate the benefits of our proposed INR method by applying it to multi-contrast MRI using the MPnRAGE sequence, where it outperforms the state-of-the-art parallel imaging compressed sensing (PICS) reconstruction method, even at higher acceleration factors.

eess.IV↗