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Andrea Cremaschi

Publications and source records attributed to Andrea Cremaschi.

20 records · Page 2Linked to original sources

Colombian Women's Life Patterns: A Multivariate Density Regression Approach

Women in Colombia face difficulties related to the patriarchal traits of their societies and well-known conflict afflicting the country since 1948. In this critical context, our aim is to study the relationship between baseline socio-demographic factors and variables associated to fertility, partnership patterns, and work activity. To best exploit the explanatory structure, we propose a Bayesian multivariate density regression model, which can accommodate mixed responses with censored, constrained, and binary traits. The flexible nature of the models allows for nonlinear regression functions and non-standard features in the errors, such as asymmetry or multi-modality. The model has interpretable covariate-dependent weights constructed through normalization, allowing for combinations of categorical and continuous covariates. Computational difficulties for inference are overcome through an adaptive truncation algorithm combining adaptive Metropolis-Hastings and sequential Monte Carlo to create a sequence of automatically truncated posterior mixtures. For our study on Colombian women's life patterns, a variety of quantities are visualised and described, and in particular, our findings highlight the detrimental impact of family violence on women's choices and behaviors.

stat.AP↗

A Bayesian approach to study synergistic interaction effects in in-vitro drug combination experiments

In cancer translational research, increasing effort is devoted to the study of the combined effect of two drugs when they are administered simultaneously. In this paper, we introduce a new approach to estimate the part of the effect of the two drugs due to the interaction of the compounds, i.e. which is due to synergistic or antagonistic effects of the two drugs, compared to a reference value representing the condition when the combined compounds do not interact, called zero-interaction. We describe an in-vitro cell viability experiment as a random experiment, by interpreting cell viability as the probability of a cell in the experiment to be viable after treatment, and including information related to different exposure conditions. We propose a flexible Bayesian spline regression framework for modelling the viability surface of two drugs combined as a function of the concentrations. Since the proposed approach is based on a statistical model, it allows to include replicates of the experiments, to evaluate the uncertainty of the estimates, and to perform prediction. We test the model fit and prediction performance on a simulation study, and on an ovarian cancer cell dataset. Posterior estimates of the zero-interaction level and of the synergy term, obtained via adaptive MCMC algorithms, are used to compute interpretable measures of efficacy of the combined experiment, including relative volume under the surface (rVUS) measures to summarise the zero-interaction and synergy terms and a bi-variate alternative to the well-known EC50 measure.

stat.AP↗