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Andrea Panarotto

Publications and source records attributed to Andrea Panarotto.

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Model-based clustering of compositional trajectories for the analysis of mobility data

Understanding urban mobility patterns is crucial for designing efficient and sustainable transportation systems. Motivated by an application to the municipality of Padova and its surroundings, we propose a novel statistical framework for the analysis and clustering of mobility trajectories derived from telephonic data. We introduce a compositional representation of individual movements that integrates the uncertain device location with information on the surrounding road network, encoding at each time point the proportions of different road types compatible with the observed position. This formulation naturally accounts for measurement uncertainty and yields trajectories evolving in the simplex. To model these data, we develop a state-space framework for compositional time series that captures both the telephonic measurement error and the temporal dynamics of the latent mobility process. Building on this representation, we propose a model-based clustering approach based on mixtures of state-space models to identify groups of trajectories with similar evolution. This allows us to aggregate individual movements into interpretable mobility patterns at the population level. The results of the case study demonstrate the ability of the approach to uncover meaningful mobility behaviors, providing insights that are potentially relevant to policy makers.

stat.AP

Robust confidence intervals for generalized linear models

Reliable uncertainty quantification is a central challenge in the analysis of modern biomedical data, where complex sources of variability often violate standard modeling assumptions. In generalized linear models (GLMs), confidence intervals for regression parameters provide such information, but they typically rely on correct specification of the mean-variance relationship. However, overdispersion, heteroskedasticity, and unobserved biological variability can lead to substantial undercoverage in practice. We propose a method for constructing confidence intervals that remains valid under variance misspecification. The approach is based on the inversion of hypothesis tests obtained by sign-flipping individual score contributions and uses a bisection algorithm to determine the interval bounds. The resulting intervals inherit robustness properties from the underlying tests, and we establish their asymptotic validity under general variance misspecification. Through simulation studies, we show that the proposed method achieves reliable coverage and outperforms standard Wald-type intervals when model assumptions are violated. We illustrate the approach in a differential expression analysis of RNA-sequencing data from a cancer study, where heterogeneous variability is pervasive and parametric methods can yield inconsistent inference. The proposed framework provides a practical and robust alternative to conventional quasi-likelihood or Wald-based methods for interval estimation in GLMs, particularly suited to high-throughput biomedical applications.

stat.ME