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Andrea Riebler

Publications and source records attributed to Andrea Riebler.

At least 19 recordsLinked to original sources

Geographical inequalities in mortality by age and gender in Italy, 2002-2019: insights from a spatial extension of the Lee-Carter model

Italy reports some of the lowest levels of mortality in the developed world. Recent evidence, however, suggests that even in low mortality countries improvements may be slowing and regional inequalities widening. This study contributes new empirical evidence to the debate by analysing mortality data by single year of age for males and females across 107 provinces in Italy from 2002 to 2019. We extend the widely used Lee Carter model to include spatially varying age specific effects, and further specify it to capture space age time interactions. The model is estimated in a Bayesian framework using the inlabru package, which builds on INLA (Integrated Nested Laplace Approximation) for non linear models and facilitates the use of smoothing priors. This approach borrows strength across provinces and years, mitigating random fluctuations in small area death counts. Results demonstrate the value of such a granular approach, highlighting the existence of an uneven geography of mortality despite overall national improvements. Mortality disadvantage is concentrated in parts of the Centre South and North West, while the Centre North and North East fare relatively better. These geographical differences have widened since 2010, with clear age and gender specific patterns, being more pronounced at younger adult ages for men and at older adult ages for women. Future work may involve refining the analysis to mortality by cause of death or socioeconomic status, informing more targeted public health policies to address mortality disparities across Italy's provinces.

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Space-Time Smoothing of Survey Outcomes using the R Package SUMMER

The increasing availability of complex survey data, and the continued need for estimates of demographic and health indicators at a fine spatial and temporal scale, which leads to issues of data sparsity, has led to the need for spatio-temporal smoothing methods that acknowledge the manner in which the data were collected. The open source R package SUMMER implements a variety of methods for spatial or spatio-temporal smoothing of survey data. The emphasis is on small-area estimation. We focus primarily on indicators in a low and middle-income countries context. Our methods are particularly useful for data from Demographic Health Surveys and Multiple Indicator Cluster Surveys. We build upon functions within the survey package, and use INLA for fast Bayesian computation. This paper includes a brief overview of these methods and illustrates the workflow of accessing and processing surveys, estimating subnational child mortality rates, and visualizing results with both simulated data and DHS surveys.

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A joint model for DHS and MICS surveys: Spatial modeling with anonymized locations

Anonymizing the GPS locations of observations can bias a spatial model's parameter estimates and attenuate spatial predictions when improperly accounted for, and is relevant in applications from public health to paleoseismology. In this work, we demonstrate that a newly introduced method for geostatistical modeling in the presence of anonymized point locations can be extended to account for more general kinds of positional uncertainty due to location anonymization, including both jittering (a form of random perturbations of GPS coordinates) and geomasking (reporting only the name of the area containing the true GPS coordinates). We further provide a numerical integration scheme that flexibly accounts for the positional uncertainty as well as spatial and covariate information. We apply the method to women's secondary education completion data in the 2018 Nigeria demographic and health survey (NDHS) containing jittered point locations, and the 2016 Nigeria multiple indicator cluster survey (NMICS) containing geomasked locations. We show that accounting for the positional uncertainty in the surveys can improve predictions in terms of their continuous rank probability score.

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Smoothing for age-period-cohort models: a comparison between splines and random process

Age-Period-Cohort (APC) models are well used in the context of modelling health and demographic data to produce smooth estimates of each time trend. When smoothing in the context of APC models, there are two main schools, frequentist using penalised smoothing splines, and Bayesian using random processes with little crossover between them. In this article, we clearly lay out the theoretical link between the two schools, provide examples using simulated and real data to highlight similarities and difference, and help a general APC user understand potentially inaccessible theory from functional analysis. As intuition suggests, both approaches lead to comparable and almost identical in-sample predictions, but random processes within a Bayesian approach might be beneficial for out-of-sample prediction as the sources of uncertainty are captured in a more complete way.

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Impact of Jittering on Raster- and Distance-based Geostatistical Analyses of DHS Data

Fine-scale covariate rasters are routinely used in geostatistical models for mapping demographic and health indicators based on household surveys from the Demographic and Health Surveys (DHS) program. However, the geostatistical analyses ignore the fact that GPS coordinates in DHS surveys are jittered for privacy purposes. We demonstrate the need to account for this jittering, and we propose a computationally efficient approach that can be routinely applied. We use the new method to analyse the prevalence of completion of secondary education for 20--49 year old women in Nigeria in 2018 based on the 2018 DHS survey. The analysis demonstrates substantial changes in the estimates of spatial range and fixed effects compared to when we ignore jittering. Through a simulation study that mimics the dataset, we demonstrate that accounting for jittering reduces attenuation in the estimated coefficients for covariates and improves predictions. The results also show that the common approach of averaging covariate values in windows around the observed locations does not lead to the same improvements as accounting for jittering.

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GeoAdjust: Adjusting for Positional Uncertainty in Geostatistial Analysis of DHS Data

The R-package GeoAdjust https://github.com/umut-altay/GeoAdjust-package implements fast empirical Bayesian geostatistical inference for household survey data from the Demographic and Health Surveys Program (DHS) using Template Model Builder (TMB). DHS household survey data is an important source of data for tracking demographic and health indicators, but positional uncertainty has been intentionally introduced in the GPS coordinates to preserve privacy. GeoAdjust accounts for such positional uncertainty in geostatistical models containing both spatial random effects and raster- and distance-based covariates. The R package supports Gaussian, binomial and Poisson likelihoods with identity link, logit link, and log link functions respectively. The user defines the desired model structure by setting a small number of function arguments, and can easily experiment with different hyperparameters for the priors. GeoAdjust is the first software package that is specifically designed to address positional uncertainty in the GPS coordinates of point referenced household survey data. The package provides inference for model parameters and can predict values at unobserved locations.

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Fast geostatistical inference under positional uncertainty: Analysing DHS household survey data

Household survey data from the Demographic and Health Surveys (DHS) Program is published with GPS coordinates. However, almost all geostatistical analyses of such data ignore that the published GPS coordinates are randomly displaced (jittered). In this short report, we develop a geostatistical model that accounts for the positional uncertainty when analysing DHS surveys, and provide a fast implementation using Template Model Builder. The key focus is inference with Gaussian random fields under positional uncertainty, and our approach works for both Gaussian and non-Gaussian likelihoods. A simulation study with a binomial observation model shows that the new approach performs equally or better than the common approach of ignoring jittering, both in terms of more accurate parameter estimates and improved predictive measures. We demonstrate that the improvement would be larger under stronger jittering. An analysis of contraceptive use in Kenya shows that the approach is fast and easy to use in practice.

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Spatial Aggregation with Respect to a Population Distribution

Spatial aggregation with respect to a population distribution involves estimating aggregate quantities for a population based on an observation of individuals in a subpopulation. In this context, a geostatistical workflow must account for three major sources of `aggregation error': aggregation weights, fine scale variation, and finite population variation. However, common practice is to treat the unknown population distribution as a known population density and ignore empirical variability in outcomes. We improve common practice by introducing a `sampling frame model' that allows aggregation models to account for the three sources of aggregation error simply and transparently. We compare the proposed and the traditional approach using two simulation studies that mimic neonatal mortality rate (NMR) data from the 2014 Kenya Demographic and Health Survey (KDHS2014). For the traditional approach, undercoverage/overcoverage depends arbitrarily on the aggregation grid resolution, while the new approach exhibits low sensitivity. The differences between the two aggregation approaches increase as the population of an area decreases. The differences are substantial at the second administrative level and finer, but also at the first administrative level for some population quantities. We find differences between the proposed and traditional approach are consistent with those we observe in an application to NMR data from the KDHS2014.

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makemyprior: Intuitive Construction of Joint Priors for Variance Parameters in R

Priors allow us to robustify inference and to incorporate expert knowledge in Bayesian hierarchical models. This is particularly important when there are random effects that are hard to identify based on observed data. The challenge lies in understanding and controlling the joint influence of the priors for the variance parameters, and makemyprior is an R package that guides the formulation of joint prior distributions for variance parameters. A joint prior distribution is constructed based on a hierarchical decomposition of the total variance in the model along a tree, and takes the entire model structure into account. Users input their prior beliefs or express ignorance at each level of the tree. Prior beliefs can be general ideas about reasonable ranges of variance values and need not be detailed expert knowledge. The constructed priors lead to robust inference and guarantee proper posteriors. A graphical user interface facilitates construction and assessment of different choices of priors through visualization of the tree and joint prior. The package aims to expand the toolbox of applied researchers and make priors an active component in their Bayesian workflow.

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Bayesian Multiresolution Modeling Of Georeferenced Data

Current implementations of multiresolution methods are limited in terms of possible types of responses and approaches to inference. We provide a multiresolution approach for spatial analysis of non-Gaussian responses using latent Gaussian models and Bayesian inference via integrated nested Laplace approximation (INLA). The approach builds on `LatticeKrig', but uses a reparameterization of the model parameters that is intuitive and interpretable so that modeling and prior selection can be guided by expert knowledge about the different spatial scales at which dependence acts. The priors can be used to make inference robust and integration over model parameters allows for more accurate posterior estimates of uncertainty. The extended LatticeKrig (ELK) model is compared to a standard implementation of LatticeKrig (LK), and a standard Matérn model, and we find modest improvement in spatial oversmoothing and prediction for the ELK model for counts of secondary education completion for women in Kenya collected in the 2014 Kenya demographic health survey. Through a simulation study with Gaussian responses and a realistic mix of short and long scale dependencies, we demonstrate that the differences between the three approaches for prediction increases with distance to nearest observation.

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Design- and Model-Based Approaches to Small-Area Estimation in a Low and Middle Income Country Context: Comparisons and Recommendations

The need for rigorous and timely health and demographic summaries has provided the impetus for an explosion in geographic studies, with a common approach being the production of pixel-level maps, particularly in low and middle income countries. In this context, household surveys are a major source of data, usually with a two-stage cluster design with stratification by region and urbanicity. Accurate estimates are of crucial interest for precision public health policy interventions, but many current studies take a cavalier approach to acknowledging the sampling design, while presenting results at a fine geographic scale. In this paper we investigate the extent to which accounting for sample design can affect predictions at the aggregate level, which is usually the target of inference. We describe a simulation study in which realistic sampling frames are created for Kenya, based on population and demographic information, with a survey design that mimics a Demographic Health Survey (DHS). We compare the predictive performance of various commonly-used models. We also describe a cluster level model with a discrete spatial smoothing prior that has not been previously used, but provides reliable inference. We find that including stratification and cluster level random effects can improve predictive performance. Spatially smoothed direct (weighted) estimates were robust to priors and survey design. Continuous spatial models performed well in the presence of fine scale variation; however, these models require the most "hand holding". Subsequently, we examine how the models perform on real data; specifically we model the prevalence of secondary education for women aged 20-29 using data from the 2014 Kenya DHS.

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Intuitive joint priors for variance parameters

Variance parameters in additive models are typically assigned independent priors that do not account for model structure. We present a new framework for prior selection based on a hierarchical decomposition of the total variance along a tree structure to the individual model components. For each split in the tree, an analyst may be ignorant or have a sound intuition on how to attribute variance to the branches. In the former case a Dirichlet prior is appropriate to use, while in the latter case a penalised complexity (PC) prior provides robust shrinkage. A bottom-up combination of the conditional priors results in a proper joint prior. We suggest default values for the hyperparameters and offer intuitive statements for eliciting the hyperparameters based on expert knowledge. The prior framework is applicable for R packages for Bayesian inference such as INLA and RStan. Three simulation studies show that, in terms of the application-specific measures of interest, PC priors improve inference over Dirichlet priors when used to penalise different levels of complexity in splits. However, when expressing ignorance in a split, Dirichlet priors perform equally well and are preferred for their simplicity. We find that assigning current state-of-the-art default priors for each variance parameter individually is less transparent and does not perform better than using the proposed joint priors. We demonstrate practical use of the new framework by analysing spatial heterogeneity in neonatal mortality in Kenya in 2010-2014 based on complex survey data.

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Integrated Nested Laplace Approximations (INLA)

This is a short description and basic introduction to the Integrated nested Laplace approximations (INLA) approach. INLA is a deterministic paradigm for Bayesian inference in latent Gaussian models (LGMs) introduced in Rue et al. (2009). INLA relies on a combination of analytical approximations and efficient numerical integration schemes to achieve highly accurate deterministic approximations to posterior quantities of interest. The main benefit of using INLA instead of Markov chain Monte Carlo (MCMC) techniques for LGMs is computational; INLA is fast even for large, complex models. Moreover, being a deterministic algorithm, INLA does not suffer from slow convergence and poor mixing. INLA is implemented in the R package R-INLA, which represents a user-friendly and versatile tool for doing Bayesian inference. R-INLA returns posterior marginals for all model parameters and the corresponding posterior summary information. Model choice criteria as well as predictive diagnostics are directly available. Here, we outline the theory behind INLA, present the R-INLA package and describe new developments of combining INLA with MCMC for models that are not possible to fit with R-INLA.

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Spatial modelling with R-INLA: A review

Coming up with Bayesian models for spatial data is easy, but performing inference with them can be challenging. Writing fast inference code for a complex spatial model with realistically-sized datasets from scratch is time-consuming, and if changes are made to the model, there is little guarantee that the code performs well. The key advantages of R-INLA are the ease with which complex models can be created and modified, without the need to write complex code, and the speed at which inference can be done even for spatial problems with hundreds of thousands of observations. R-INLA handles latent Gaussian models, where fixed effects, structured and unstructured Gaussian random effects are combined linearly in a linear predictor, and the elements of the linear predictor are observed through one or more likelihoods. The structured random effects can be both standard areal model such as the Besag and the BYM models, and geostatistical models from a subset of the Matérn Gaussian random fields. In this review, we discuss the large success of spatial modelling with R-INLA and the types of spatial models that can be fitted, we give an overview of recent developments for areal models, and we give an overview of the stochastic partial differential equation (SPDE) approach and some of the ways it can be extended beyond the assumptions of isotropy and separability. In particular, we describe how slight changes to the SPDE approach leads to straight-forward approaches for non-stationary spatial models and non-separable space-time models.

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Estimating Under Five Mortality in Space and Time in a Developing World Context

Accurate estimates of the under-5 mortality rate (U5MR) in a developing world context are a key barometer of the health of a nation. This paper describes new models to analyze survey data on mortality in this context. We are interested in both spatial and temporal description, that is, wishing to estimate U5MR across regions and years, and to investigate the association between the U5MR and spatially-varying covariate surfaces. We illustrate the methodology by producing yearly estimates for subnational areas in Kenya over the period 1980 - 2014 using data from demographic health surveys (DHS). We use a binomial likelihood with fixed effects for the urban/rural stratification to account for the complex survey design. We carry out smoothing using Bayesian hierarchical models with continuous spatial and temporally discrete components. A key component of the model is an offset to adjust for bias due to the effects of HIV epidemics. Substantively, there has been a sharp decline in U5MR in the period 1980 - 2014, but large variability in estimated subnational rates remains. A priority for future research is understanding this variability. Temperature, precipitation and a measure of malaria infection prevalence were candidates for inclusion in the covariate model.

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Bayesian Computing with INLA: A Review

The key operation in Bayesian inference, is to compute high-dimensional integrals. An old approximate technique is the Laplace method or approximation, which dates back to Pierre- Simon Laplace (1774). This simple idea approximates the integrand with a second order Taylor expansion around the mode and computes the integral analytically. By developing a nested version of this classical idea, combined with modern numerical techniques for sparse matrices, we obtain the approach of Integrated Nested Laplace Approximations (INLA) to do approximate Bayesian inference for latent Gaussian models (LGMs). LGMs represent an important model-abstraction for Bayesian inference and include a large proportion of the statistical models used today. In this review, we will discuss the reasons for the success of the INLA-approach, the R-INLA package, why it is so accurate, why the approximations are very quick to compute and why LGMs make such a useful concept for Bayesian computing.

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meta4diag: Bayesian Bivariate Meta-analysis of Diagnostic Test Studies for Routine Practice

This paper introduces the \proglang{R} package \pkg{meta4diag} for implementing Bayesian bivariate meta-analyses of diagnostic test studies. Our package \pkg{meta4diag} is a purpose-built front end of the \proglang{R} package \pkg{INLA}. While \pkg{INLA} offers full Bayesian inference for the large set of latent Gaussian models using integrated nested Laplace approximations, \pkg{meta4diag} extracts the features needed for bivariate meta-analysis and presents them in an intuitive way. It allows the user a straightforward model-specification and offers user-specific prior distributions. Further, the newly proposed penalised complexity prior framework is supported, which builds on prior intuitions about the behaviours of the variance and correlation parameters. Accurate posterior marginal distributions for sensitivity and specificity as well as all hyperparameters, and covariates are directly obtained without Markov chain Monte Carlo sampling. Further, univariate estimates of interest, such as odds ratios, as well as the SROC curve and other common graphics are directly available for interpretation. An interactive graphical user interface provides the user with the full functionality of the package without requiring any \proglang{R} programming. The package is available through CRAN \url{https://cran.r-project.org/web/packages/meta4diag/} and its usage will be illustrated using three real data examples.

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An intuitive Bayesian spatial model for disease mapping that accounts for scaling

In recent years, disease mapping studies have become a routine application within geographical epidemiology and are typically analysed within a Bayesian hierarchical model formulation. A variety of model formulations for the latent level have been proposed but all come with inherent issues. In the classical BYM model, the spatially structured component cannot be seen independently from the unstructured component. This makes prior definitions for the hyperparameters of the two random effects challenging. There are alternative model formulations that address this confounding, however, the issue on how to choose interpretable hyperpriors is still unsolved. Here, we discuss a recently proposed parameterisation of the BYM model that leads to improved parameter control as the hyperparameters can be seen independently from each other. Furthermore, the need for a scaled spatial component is addressed, which facilitates assignment of interpretable hyperpriors and make these transferable between spatial applications with different graph structures. We provide implementation details for the new model formulation which preserve sparsity properties, and we investigate systematically the model performance and compare it to existing parameterisations. Through a simulation study, we show that the new model performs well, both showing good learning abilities and good shrinkage behaviour. In terms of model choice criteria, the proposed model performs at least equally well as existing parameterisations, but only the new formulation offers parameters that are interpretable and hyperpriors that have a clear meaning.

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