arXiv subjects

Andreas Maier

Publications and source records attributed to Andreas Maier.

At least 343 records · Page 19Linked to original sources

arXiv2021

Bayesian U-Net for Segmenting Glaciers in SAR Imagery

Fluctuations of the glacier calving front have an important influence over the ice flow of whole glacier systems. It is therefore important to precisely monitor the position of the calving front. However, the manual delineation of SAR images is a difficult, laborious and subjective task. Convolutional neural networks have previously shown promising results in automating the glacier segmentation in SAR images, making them desirable for further exploration of their possibilities. In this work, we propose to compute uncertainty and use it in an Uncertainty Optimization regime as a novel two-stage process. By using dropout as a random sampling layer in a U-Net architecture, we create a probabilistic Bayesian Neural Network. With several forward passes, we create a sampling distribution, which can estimate the model uncertainty for each pixel in the segmentation mask. The additional uncertainty map information can serve as a guideline for the experts in the manual annotation of the data. Furthermore, feeding the uncertainty map to the network leads to 95.24% Dice similarity, which is an overall improvement in the segmentation performance compared to the state-of-the-art deterministic U-Net-based glacier segmentation pipelines.

cs.LG↗

arXiv2021

Robust Classification from Noisy Labels: Integrating Additional Knowledge for Chest Radiography Abnormality Assessment

Chest radiography is the most common radiographic examination performed in daily clinical practice for the detection of various heart and lung abnormalities. The large amount of data to be read and reported, with more than 100 studies per day for a single radiologist, poses a challenge in consistently maintaining high interpretation accuracy. The introduction of large-scale public datasets has led to a series of novel systems for automated abnormality classification. However, the labels of these datasets were obtained using natural language processed medical reports, yielding a large degree of label noise that can impact the performance. In this study, we propose novel training strategies that handle label noise from such suboptimal data. Prior label probabilities were measured on a subset of training data re-read by 4 board-certified radiologists and were used during training to increase the robustness of the training model to the label noise. Furthermore, we exploit the high comorbidity of abnormalities observed in chest radiography and incorporate this information to further reduce the impact of label noise. Additionally, anatomical knowledge is incorporated by training the system to predict lung and heart segmentation, as well as spatial knowledge labels. To deal with multiple datasets and images derived from various scanners that apply different post-processing techniques, we introduce a novel image normalization strategy. Experiments were performed on an extensive collection of 297,541 chest radiographs from 86,876 patients, leading to a state-of-the-art performance level for 17 abnormalities from 2 datasets. With an average AUC score of 0.880 across all abnormalities, our proposed training strategies can be used to significantly improve performance scores.

cs.CV↗

arXiv2021

Spatio-Temporal Handwriting Imitation

Most people think that their handwriting is unique and cannot be imitated by machines, especially not using completely new content. Current cursive handwriting synthesis is visually limited or needs user interaction. We show that subdividing the process into smaller subtasks makes it possible to imitate someone's handwriting with a high chance to be visually indistinguishable for humans. Therefore, a given handwritten sample will be used as the target style. This sample is transferred to an online sequence. Then, a method for online handwriting synthesis is used to produce a new realistic-looking text primed with the online input sequence. This new text is then rendered and style-adapted to the input pen. We show the effectiveness of the pipeline by generating in- and out-of-vocabulary handwritten samples that are validated in a comprehensive user study. Additionally, we show that also a typical writer identification system can partially be fooled by the created fake handwritings.

cs.CV↗

arXiv2021

Combined subleading high-energy logarithms and NLO accuracy for W production in association with multiple jets

Large logarithmic corrections in $\hat s/p_t^2$ lead to substantial variations in the perturbative predictions for inclusive $W$-plus-dijet processes at the Large Hadron Collider. This instability can be cured by summing the leading-logarithmic contributions in $\hat s/p_t^2$ to all orders in $α_s$. As expected though, leading logarithmic accuracy is insufficient to guarantee a suitable description in regions of phase space away from the high energy limit. We present (i) the first calculation of all partonic channels contributing at next-to-leading logarithmic order in $W$-boson production in association with at least two jets, and (ii) bin-by-bin matching to next-to-leading fixed-order accuracy. This new perturbative input is implemented in \emph{High Energy Jets}, and systematically improves the description of available experimental data in regions of phase space which are formally subleading with respect to $\hat s/p_t^2$.

hep-ph↗

arXiv2021

Joint Super-Resolution and Rectification for Solar Cell Inspection

Visual inspection of solar modules is an important monitoring facility in photovoltaic power plants. Since a single measurement of fast CMOS sensors is limited in spatial resolution and often not sufficient to reliably detect small defects, we apply multi-frame super-resolution (MFSR) to a sequence of low resolution measurements. In addition, the rectification and removal of lens distortion simplifies subsequent analysis. Therefore, we propose to fuse this pre-processing with standard MFSR algorithms. This is advantageous, because we omit a separate processing step, the motion estimation becomes more stable and the spacing of high-resolution (HR) pixels on the rectified module image becomes uniform w. r. t. the module plane, regardless of perspective distortion. We present a comprehensive user study showing that MFSR is beneficial for defect recognition by human experts and that the proposed method performs better than the state of the art. Furthermore, we apply automated crack segmentation and show that the proposed method performs 3x better than bicubic upsampling and 2x better than the state of the art for automated inspection.

cs.CV↗

arXiv2021

MR-Contrast-Aware Image-to-Image Translations with Generative Adversarial Networks

Purpose A Magnetic Resonance Imaging (MRI) exam typically consists of several sequences that yield different image contrasts. Each sequence is parameterized through multiple acquisition parameters that influence image contrast, signal-to-noise ratio, acquisition time, and/or resolution. Depending on the clinical indication, different contrasts are required by the radiologist to make a diagnosis. As MR sequence acquisition is time consuming and acquired images may be corrupted due to motion, a method to synthesize MR images with adjustable contrast properties is required. Methods Therefore, we trained an image-to-image generative adversarial network conditioned on the MR acquisition parameters repetition time and echo time. Our approach is motivated by style transfer networks, whereas the "style" for an image is explicitly given in our case, as it is determined by the MR acquisition parameters our network is conditioned on. Results This enables us to synthesize MR images with adjustable image contrast. We evaluated our approach on the fastMRI dataset, a large set of publicly available MR knee images, and show that our method outperforms a benchmark pix2pix approach in the translation of non-fat-saturated MR images to fat-saturated images. Our approach yields a peak signal-to-noise ratio and structural similarity of 24.48 and 0.66, surpassing the pix2pix benchmark model significantly. Conclusion Our model is the first that enables fine-tuned contrast synthesis, which can be used to synthesize missing MR contrasts or as a data augmentation technique for AI training in MRI.

eess.IV↗

arXiv2021

Quantifying the Scanner-Induced Domain Gap in Mitosis Detection

Automated detection of mitotic figures in histopathology images has seen vast improvements, thanks to modern deep learning-based pipelines. Application of these methods, however, is in practice limited by strong variability of images between labs. This results in a domain shift of the images, which causes a performance drop of the models. Hypothesizing that the scanner device plays a decisive role in this effect, we evaluated the susceptibility of a standard mitosis detection approach to the domain shift introduced by using a different whole slide scanner. Our work is based on the MICCAI-MIDOG challenge 2021 data set, which includes 200 tumor cases of human breast cancer and four scanners. Our work indicates that the domain shift induced not by biochemical variability but purely by the choice of acquisition device is underestimated so far. Models trained on images of the same scanner yielded an average F1 score of 0.683, while models trained on a single other scanner only yielded an average F1 score of 0.325. Training on another multi-domain mitosis dataset led to mean F1 scores of 0.52. We found this not to be reflected by domain-shifts measured as proxy A distance-derived metric.

cs.CV↗

arXiv2021

Cephalogram Synthesis and Landmark Detection in Dental Cone-Beam CT Systems

Due to the lack of standardized 3D cephalometric analytic methodology, 2D cephalograms synthesized from 3D cone-beam computed tomography (CBCT) volumes are widely used for cephalometric analysis in dental CBCT systems. However, compared with conventional X-ray film based cephalograms, such synthetic cephalograms lack image contrast and resolution. In addition, the radiation dose during the scan for 3D reconstruction causes potential health risks. In this work, we propose a sigmoid-based intensity transform that uses the nonlinear optical property of X-ray films to increase image contrast of synthetic cephalograms. To improve image resolution, super resolution deep learning techniques are investigated. For low dose purpose, the pixel-to-pixel generative adversarial network (pix2pixGAN) is proposed for 2D cephalogram synthesis directly from two CBCT projections. For landmark detection in the synthetic cephalograms, an efficient automatic landmark detection method using the combination of LeNet-5 and ResNet50 is proposed. Our experiments demonstrate the efficacy of pix2pixGAN in 2D cephalogram synthesis, achieving an average peak signal-to-noise ratio (PSNR) value of 33.8 with reference to the cephalograms synthesized from 3D CBCT volumes. Pix2pixGAN also achieves the best performance in super resolution, achieving an average PSNR value of 32.5 without the introduction of checkerboard or jagging artifacts. Our proposed automatic landmark detection method achieves 86.7% successful detection rate in the 2 mm clinical acceptable range on the ISBI Test1 data, which is comparable to the state-of-the-art methods. The method trained on conventional cephalograms can be directly applied to landmark detection in the synthetic cephalograms, achieving 93.0% and 80.7% successful detection rate in 4 mm precision range for synthetic cephalograms from 3D volumes and 2D projections respectively.

eess.IV↗

arXiv2021

Adapt Everywhere: Unsupervised Adaptation of Point-Clouds and Entropy Minimisation for Multi-modal Cardiac Image Segmentation

Deep learning models are sensitive to domain shift phenomena. A model trained on images from one domain cannot generalise well when tested on images from a different domain, despite capturing similar anatomical structures. It is mainly because the data distribution between the two domains is different. Moreover, creating annotation for every new modality is a tedious and time-consuming task, which also suffers from high inter- and intra- observer variability. Unsupervised domain adaptation (UDA) methods intend to reduce the gap between source and target domains by leveraging source domain labelled data to generate labels for the target domain. However, current state-of-the-art (SOTA) UDA methods demonstrate degraded performance when there is insufficient data in source and target domains. In this paper, we present a novel UDA method for multi-modal cardiac image segmentation. The proposed method is based on adversarial learning and adapts network features between source and target domain in different spaces. The paper introduces an end-to-end framework that integrates: a) entropy minimisation, b) output feature space alignment and c) a novel point-cloud shape adaptation based on the latent features learned by the segmentation model. We validated our method on two cardiac datasets by adapting from the annotated source domain, bSSFP-MRI (balanced Steady-State Free Procession-MRI), to the unannotated target domain, LGE-MRI (Late-gadolinium enhance-MRI), for the multi-sequence dataset; and from MRI (source) to CT (target) for the cross-modality dataset. The results highlighted that by enforcing adversarial learning in different parts of the network, the proposed method delivered promising performance, compared to other SOTA methods.

cs.CV↗

arXiv2021

On Mathews Correlation Coefficient and Improved Distance Map Loss for Automatic Glacier Calving Front Segmentation in SAR Imagery

The vast majority of the outlet glaciers and ice streams of the polar ice sheets end in the ocean. Ice mass loss via calving of the glaciers into the ocean has increased over the last few decades. Information on the temporal variability of the calving front position provides fundamental information on the state of the glacier and ice stream, which can be exploited as calibration and validation data to enhance ice dynamics modeling. To identify the calving front position automatically, deep neural network-based semantic segmentation pipelines can be used to delineate the acquired SAR imagery. However, the extreme class imbalance is highly challenging for the accurate calving front segmentation in these images. Therefore, we propose the use of the Mathews correlation coefficient (MCC) as an early stopping criterion because of its symmetrical properties and its invariance towards class imbalance. Moreover, we propose an improvement to the distance map-based binary cross-entropy (BCE) loss function. The distance map adds context to the loss function about the important regions for segmentation and helps accounting for the imbalanced data. Using Mathews correlation coefficient as early stopping demonstrates an average 15% dice coefficient improvement compared to the commonly used BCE. The modified distance map loss further improves the segmentation performance by another 2%. These results are encouraging as they support the effectiveness of the proposed methods for segmentation problems suffering from extreme class imbalances.

eess.IV↗

arXiv2021

Pixel-wise Distance Regression for Glacier Calving Front Detection and Segmentation

Glacier calving front position (CFP) is an important glaciological variable. Traditionally, delineating the CFPs has been carried out manually, which was subjective, tedious and expensive. Automating this process is crucial for continuously monitoring the evolution and status of glaciers. Recently, deep learning approaches have been investigated for this application. However, the current methods get challenged by a severe class-imbalance problem. In this work, we propose to mitigate the class-imbalance between the calving front class and the non-calving front class by reformulating the segmentation problem into a pixel-wise regression task. A Convolutional Neural Network gets optimized to predict the distance values to the glacier front for each pixel in the image. The resulting distance map localizes the CFP and is further post-processed to extract the calving front line. We propose three post-processing methods, one method based on statistical thresholding, a second method based on conditional random fields (CRF), and finally the use of a second U-Net. The experimental results confirm that our approach significantly outperforms the state-of-the-art methods and produces accurate delineation. The Second U-Net obtains the best performance results, resulting in an average improvement of about 21% dice coefficient enhancement.

cs.CV↗

arXiv2021

Enhanced Magnetic Resonance Image Synthesis with Contrast-Aware Generative Adversarial Networks

A Magnetic Resonance Imaging (MRI) exam typically consists of the acquisition of multiple MR pulse sequences, which are required for a reliable diagnosis. Each sequence can be parameterized through multiple acquisition parameters affecting MR image contrast, signal-to-noise ratio, resolution, or scan time. With the rise of generative deep learning models, approaches for the synthesis of MR images are developed to either synthesize additional MR contrasts, generate synthetic data, or augment existing data for AI training. However, current generative approaches for the synthesis of MR images are only trained on images with a specific set of acquisition parameter values, limiting the clinical value of these methods as various sets of acquisition parameter settings are used in clinical practice. Therefore, we trained a generative adversarial network (GAN) to generate synthetic MR knee images conditioned on various acquisition parameters (repetition time, echo time, image orientation). This approach enables us to synthesize MR images with adjustable image contrast. In a visual Turing test, two experts mislabeled 40.5% of real and synthetic MR images, demonstrating that the image quality of the generated synthetic and real MR images is comparable. This work can support radiologists and technologists during the parameterization of MR sequences by previewing the yielded MR contrast, can serve as a valuable tool for radiology training, and can be used for customized data generation to support AI training.

eess.IV↗

arXiv2021

Rigid and non-rigid motion compensation in weight-bearing cone-beam CT of the knee using (noisy) inertial measurements

Involuntary subject motion is the main source of artifacts in weight-bearing cone-beam CT of the knee. To achieve image quality for clinical diagnosis, the motion needs to be compensated. We propose to use inertial measurement units (IMUs) attached to the leg for motion estimation. We perform a simulation study using real motion recorded with an optical tracking system. Three IMU-based correction approaches are evaluated, namely rigid motion correction, non-rigid 2D projection deformation and non-rigid 3D dynamic reconstruction. We present an initialization process based on the system geometry. With an IMU noise simulation, we investigate the applicability of the proposed methods in real applications. All proposed IMU-based approaches correct motion at least as good as a state-of-the-art marker-based approach. The structural similarity index and the root mean squared error between motion-free and motion corrected volumes are improved by 24-35% and 78-85%, respectively, compared with the uncorrected case. The noise analysis shows that the noise levels of commercially available IMUs need to be improved by a factor of $10^5$ which is currently only achieved by specialized hardware not robust enough for the application. The presented study confirms the feasibility of this novel approach and defines improvements necessary for a real application.

eess.IV↗

arXiv2021

Deep Learning compatible Differentiable X-ray Projections for Inverse Rendering

Many minimally invasive interventional procedures still rely on 2D fluoroscopic imaging. Generating a patient-specific 3D model from these X-ray projection data would allow to improve the procedural workflow, e.g. by providing assistance functions such as automatic positioning. To accomplish this, two things are required. First, a statistical human shape model of the human anatomy and second, a differentiable X-ray renderer. In this work, we propose a differentiable renderer by deriving the distance travelled by a ray inside mesh structures to generate a distance map. To demonstrate its functioning, we use it for simulating X-ray images from human shape models. Then we show its application by solving the inverse problem, namely reconstructing 3D models from real 2D fluoroscopy images of the pelvis, which is an ideal anatomical structure for patient registration. This is accomplished by an iterative optimization strategy using gradient descent. With the majority of the pelvis being in the fluoroscopic field of view, we achieve a mean Hausdorff distance of 30 mm between the reconstructed model and the ground truth segmentation.

eess.IV↗

arXiv2021

Learning the Update Operator for 2D/3D Image Registration

Image guidance in minimally invasive interventions is usually provided using live 2D X-ray imaging. To enhance the information available during the intervention, the preoperative volume can be overlaid over the 2D images using 2D/3D image registration. Recently, deep learning-based 2D/3D registration methods have shown promising results by improving computational efficiency and robustness. However, there is still a gap in terms of registration accuracy compared to traditional optimization-based methods. We aim to address this gap by incorporating traditional methods in deep neural networks using known operator learning. As an initial step in this direction, we propose to learn the update step of an iterative 2D/3D registration framework based on the Point-to-Plane Correspondence model. We embed the Point-to-Plane Correspondence model as a known operator in our deep neural network and learn the update step for the iterative registration. We show an improvement of 1.8 times in terms of registration accuracy for the update step prediction compared to learning without the known operator.

cs.CV↗

arXiv2021

SkinScan: Low-Cost 3D-Scanning for Dermatologic Diagnosis and Documentation

The utilization of computational photography becomes increasingly essential in the medical field. Today, imaging techniques for dermatology range from two-dimensional (2D) color imagery with a mobile device to professional clinical imaging systems measuring additional detailed three-dimensional (3D) data. The latter are commonly expensive and not accessible to a broad audience. In this work, we propose a novel system and software framework that relies only on low-cost (and even mobile) commodity devices present in every household to measure detailed 3D information of the human skin with a 3D-gradient-illumination-based method. We believe that our system has great potential for early-stage diagnosis and monitoring of skin diseases, especially in vastly populated or underdeveloped areas.

eess.IV↗

arXiv2021

Learning-Based Patch-Wise Metal Segmentation with Consistency Check

Metal implants that are inserted into the patient's body during trauma interventions cause heavy artifacts in 3D X-ray acquisitions. Metal Artifact Reduction (MAR) methods, whose first step is always a segmentation of the present metal objects, try to remove these artifacts. Thereby, the segmentation is a crucial task which has strong influence on the MAR's outcome. This study proposes and evaluates a learning-based patch-wise segmentation network and a newly proposed Consistency Check as post-processing step. The combination of the learned segmentation and Consistency Check reaches a high segmentation performance with an average IoU score of 0.924 on the test set. Furthermore, the Consistency Check proves the ability to significantly reduce false positive segmentations whilst simultaneously ensuring consistent segmentations.

eess.IV↗

arXiv2021

X-ray Scatter Estimation Using Deep Splines

Algorithmic X-ray scatter compensation is a desirable technique in flat-panel X-ray imaging and cone-beam computed tomography. State-of-the-art U-net based image translation approaches yielded promising results. As there are no physics constraints applied to the output of the U-Net, it cannot be ruled out that it yields spurious results. Unfortunately, those may be misleading in the context of medical imaging. To overcome this problem, we propose to embed B-splines as a known operator into neural networks. This inherently limits their predictions to well-behaved and smooth functions. In a study using synthetic head and thorax data as well as real thorax phantom data, we found that our approach performed on par with U-net when comparing both algorithms based on quantitative performance metrics. However, our approach not only reduces runtime and parameter complexity, but we also found it much more robust to unseen noise levels. While the U-net responded with visible artifacts, our approach preserved the X-ray signal's frequency characteristics.

physics.med-ph↗