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Andreia V. Faria

Publications and source records attributed to Andreia V. Faria.

3 recordsLinked to original sources

Classifier Pooling for Modern Ordinal Classification

Ordinal data is widely prevalent in clinical and other domains, yet there is a lack of both modern, machine-learning based methods and publicly available software to address it. In this paper, we present a model-agnostic method of ordinal classification, which can apply any non-ordinal classification method in an ordinal fashion. We also provide an open-source implementation of these algorithms, in the form of a Python package. We apply these models on multiple real-world datasets to show their performance across domains. We show that they often outperform non-ordinal classification methods, especially when the number of datapoints is relatively small or when there are many classes of outcomes. This work, including the developed software, facilitates the use of modern, more powerful machine learning algorithms to handle ordinal data.

cs.LG

Regularized regression on compositional trees with application to MRI analysis

A compositional tree refers to a tree structure on a set of random variables where each random variable is a node and composition occurs at each non-leaf node of the tree. As a generalization of compositional data, compositional trees handle more complex relationships among random variables and appear in many disciplines, such as brain imaging, genomics and finance. We consider the problem of sparse regression on data that are associated with a compositional tree and propose a transformation-free tree-based regularized regression method for component selection. The regularization penalty is designed based on the tree structure and encourages a sparse tree representation. We prove that our proposed estimator for regression coefficients is both consistent and model selection consistent. In the simulation study, our method shows higher accuracy than competing methods under different scenarios. By analyzing a brain imaging data set from studies of Alzheimer's disease, our method identifies meaningful associations between memory declination and volume of brain regions that are consistent with current understanding.

stat.ME

Identifying brain hierarchical structures associated with Alzheimer's disease using a regularized regression method with tree predictors

Brain segmentation at different levels is generally represented as hierarchical trees. Brain regional atrophy at specific levels was found to be marginally associated with Alzheimer's disease outcomes. In this study, we propose an L1-type regularization for predictors that follow a hierarchical tree structure. Considering a tree as a directed acyclic graph, we interpret the model parameters from a path analysis perspective. Under this concept, the proposed penalty regulates the total effect of each predictor on the outcome. With regularity conditions, it is shown that under the proposed regularization, the estimator of the model coefficient is consistent in L2-norm and the model selection is also consistent. By applying to a brain structural magnetic resonance imaging dataset acquired from the Alzheimer's Disease Neuroimaging Initiative, the proposed approach identifies brain regions where atrophy in these regions demonstrates the declination in memory. With regularization on the total effects, the findings suggest that the impact of atrophy on memory deficits is localized from small brain regions but at various levels of brain segmentation.

stat.AP