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Andrew D. Jackson

Publications and source records attributed to Andrew D. Jackson.

At least 19 recordsLinked to original sources

Phases of Small Worlds: A Mean Field Formulation

A network is said to have the properties of a small world if a suitably defined average distance between any two nodes is proportional to the logarithm of the number of nodes, $N$. In this paper, we present a novel derivation of the small-world property for Gilbert-Erdös-Renyi random networks. We employ a mean field approximation that permits the analytic derivation of the distribution of shortest paths that exhibits logarithmic scaling away from the phase transition, inferable via a suitably interpreted order parameter. We begin by framing the problem in generality with a formal generating functional for undirected weighted random graphs with arbitrary disorder, recovering the result that the free energy associated with an ensemble of Gilbert graphs corresponds to a system of non-interacting fermions identified with the edge states. We then present a mean field solution for this model and extend it to more general realizations of network randomness. For a two family class of stochastic block models that we refer to as dimorphic networks, which allow for links within the different families to be drawn from two independent discrete probability distributions, we find the mean field approximation maps onto a spin chain combinatorial problem and again yields useful approximate analytic expressions for mean path lengths. Dimorophic networks exhibit a richer phase structure, where distinct small world regimes separate in analogy to the spinodal decomposition of a fluid. We find that is it possible to induce small world behavior in sub-networks that by themselves would not be in the small-world regime.

cond-mat.stat-mech

Comment on 'On biological signaling' by G. Nimtz and H. Aichmann, Z. Naturforsch. 75a: 507-509, 2020

In 2005, we proposed that the nerve pulse is an electromechanical soliton. This concept represents a challenge to the well-known Hodgkin-Huxley model which is of a purely electrical nature. The soliton theory was criticized by Nimtz and Aichmann in a recent article in Zeitung für Naturforschung A. Here, we wish to comment on some statements that we regard as misinterpretations of our views.

physics.bio-ph

Noise residuals for GW150914 using maximum likelihood and numerical relativity templates

We reexamine the results presented in a recent work by Nielsen et al. [1], in which the properties of the noise residuals in the 40\,ms chirp domain of GW150914 were investigated. This paper confirmed the presence of strong (i.e., about 0.80) correlations between residual noise in the Hanford and Livingston detectors in the chirp domain as previously seen by us [2] when using a numerical relativity template given in [3]. It was also shown in [1] that a so-called maximum likelihood template can reduce these statistically significant cross-correlations. Here, we demonstrate that the reduction of correlation and statistical significance is due to (i) the use of a peculiar template which is qualitatively different from the properties of GW150914 originally published by LIGO, (ii) a suspicious MCMC chain, (iii) uncertainties in the matching of the maximum likelihood (ML) template to the data in the Fourier domain, and (iv) a biased estimation of the significance that gives counter-intuitive results. We show that rematching the maximum likelihood template to the data in the 0.2\,s domain containing the GW150914 signal restores these correlations at the level of $60\%$ of those found in [1]. With necessary corrections, the probability given in [1] will decrease by more than one order of magnitude. Since the ML template is itself problematic, results associated with this template are illustrative rather than final.

astro-ph.IM

Degeneracy of gravitational waveforms in the context of GW150914

We study the degeneracy of theoretical gravitational waveforms for binary black hole mergers using an aligned-spin effective-one-body model. After appropriate truncation, bandpassing, and matching, we identify regions in the mass--spin parameter space containing waveforms similar to the template proposed for GW150914, with masses $m_1 = 36^{+5}_{-4} M_\odot$ and $m_2 = 29^{+4}_{-4} M_\odot$, using the cross-correlation coefficient as a measure of the similarity between waveforms. Remarkably high cross-correlations are found across broad regions of parameter space. The associated uncertanties exceed these from LIGO's Bayesian analysis considerably. We have shown that waveforms with greatly increased masses, such as $m_1 = 70 M_\odot$ and $m_2 = 35 M_\odot$, and strong anti-aligned spins ($χ_1=0.95$ and $χ_2=-0.95$) yield almost the same signal-to-noise ratio in the strain data for GW150914.

gr-qc

The free energy of biomembrane and nerve excitation and the role of anesthetics

In the electromechanical theory of nerve stimulation, the nerve impulse consists of a traveling region of solid membrane in a liquid environment. Therefore, the free energy necessary to stimulate a pulse is directly related to the free energy difference necessary to induce a phase transition in the nerve membrane. It is a function of temperature and pressure, and it is sensitively dependent on the presence of anesthetics which lower melting transitions. We investigate the free energy difference of solid and liquid membrane phases under the influence of anesthetics. We calculate stimulus-response curves of electromechanical pulses and compare them to measured stimulus-response profiles in lobster and earthworm axons. We also compare them to stimulus-response experiments on human median nerve and frog sciatic nerve published in the literature.

physics.bio-ph

A blind search for a common signal in gravitational wave detectors

We propose a blind, template-free method for the extraction of a common signal between the Hanford and Livingston detectors and apply it especially to the GW150914 event. We construct a log-likelihood method that maximizes the cross-correlation between each detector and the common signal and minimizes the cross-correlation between the residuals. The reliability of this method is tested using simulations with an injected common signal. Finally, our method is used to assess the quality of theoretical gravitational wave templates for GW150914.

astro-ph.IM

On the time lags of the LIGO signals

To date, the LIGO collaboration has detected three gravitational wave (GW) events appearing in both its Hanford and Livingston detectors. In this article we reexamine the LIGO data with regard to correlations between the two detectors. With special focus on GW150914, we report correlations in the detector noise which, at the time of the event, happen to be maximized for the same time lag as that found for the event itself. Specifically, we analyze correlations in the calibration lines in the vicinity of 35\,Hz as well as the residual noise in the data after subtraction of the best-fit theoretical templates. The residual noise for the other two events, GW151226 and GW170104, exhibits similar behavior. A clear distinction between signal and noise therefore remains to be established in order to determine the contribution of gravitational waves to the detected signals.

astro-ph.IM

Possible associated signal with GW150914 in the LIGO data

We present a simple method for the identification of weak signals associated with gravitational wave events. Its application reveals a signal with the same time lag as the GW150914 event in the released LIGO strain data with a significance around $3.2σ$. This signal starts about 10 minutes before GW150914 and lasts for about 45 minutes. Subsequent tests suggest that this signal is likely to be due to external sources.

astro-ph.IM

Solitary electromechanical pulses in Lobster neurons

Investigations of nerve activity have focused predominantly on electrical phenomena. Nerves, however, are thermodynamic systems, and changes in temperature and in the dimensions of the nerve can also be observed during the action potential. Measurements of heat changes during the action potential suggest that the nerve pulse shares many characteristics with an adiabatic pulse. First experiments in the 1980s suggested small changes in nerve thickness and length during the action potential. Such findings have led to the suggestion that the action potential may be related to electromechanical solitons traveling without dissipation. However, they have been no modern attempts to study mechanical phenomena in nerves. Here, we present ultrasensitive AFM recordings of mechanical changes on the order of 2 - 12 Å in the giant axons of the lobster. We show that the nerve thickness changes in phase with voltage change. When stimulated at opposite ends of the same axon, colliding action potentials pass through one another and do not annihilate. These observations are consistent with a mechanical interpretation of the nervous impulse.

physics.bio-ph

Skewness and Kurtosis as Indicators of Non-Gaussianity in Galactic Foreground Maps

Observational cosmology is entering an era in which high precision will be required in both measurement and data analysis. Accuracy, however, can only be achieved with a thorough understanding of potential sources of contamination from foreground effects. Our primary focus will be on non- Gaussian effects in foregrounds. This issue will be crucial for coming experiments to determine B-mode polarization. We propose a novel method for investigating a data set in terms of skewness and kurtosis in locally defined regions that collectively cover the entire sky. The method is demonstrated on two sky maps: (i) the SMICA map of Cosmic Microwave Background fluctuations provided by the Planck Collaboration and (ii) a version of the Haslam map at 408 MHz that describes synchrotron radiation. We find that skewness and kurtosis can be evaluated in combination to reveal local physical information. In the present case, we demonstrate that the local properties of both maps are predominantly Gaussian. This result was expected for the SMICA map; that it also applies for the Haslam map is surprising. The approach described here has a generality and flexibility that should make it useful in a variety of astrophysical and cosmological contexts.

astro-ph.CO

The Kullback-Leibler Divergence as an Estimator of the Statistical Properties of CMB Maps

The identification of unsubtracted foreground residuals in the cosmic microwave background maps on large scales is of crucial importance for the analysis of polarization signals. These residuals add a non-Gaussian contribution to the data. We propose the Kullback-Leibler (KL) divergence as an effective, non-parametric test on the one-point probability distribution function of the data. With motivation in information theory, the KL divergence takes into account the entire range of the distribution and is highly non-local. We demonstrate its use by analyzing the large scales of the Planck 2013 SMICA temperature fluctuation map and find it consistent with the expected distribution at a level of 6%. Comparing the results to those obtained using the more popular Kolmogorov-Smirnov test, we find the two methods to be in general agreement.

astro-ph.CO

Fluctuations of systems in finite heat reservoirs with applications to phase transitions in lipid membranes

In an adiabatically shielded system the total enthalpy is conserved. Enthalpy fluctuations of an arbitrarily chosen subsystem must be buffered by the remainder of the total system which serves as a heat reservoir. The magnitude of these fluctuations depends on the size of the reservoir. This leads to various interesting consequences for the physical behavior of the subsystem. As an example, we treat a lipid membrane with a phase transition that is embedded in an aqueous reservoir. We find that large fluctuations are attenuated when the reservoir has finite size. This has consequences for the compressibility of the membrane since volume and area fluctuations are also attenuated. We compare the equilibrium fluctuations of subsystems in finite reservoirs with those in periodically driven systems. In such systems, the subsystem has only finite time available to exchange heat with the surrounding medium. A larger frequency therefore reduces the volume of the accessible heat reservoir. Consequently, the fluctuations of the subsystem display a frequency dependence. While this work is of particular interest for a subsystem displaying a transition such as a lipid membrane, some of the results are of a generic nature and may contribute to a better understanding of relaxation processes in general.

physics.bio-ph

Low Frequency Sound Propagation in Lipid Membranes

In the recent years we have shown that cylindrical biological membranes such as nerve axons under physiological conditions are able to support stable electromechanical pulses called solitons. These pulses share many similarities with the nervous impulse, e.g., the propagation velocity as well as the measured reversible heat production and changes in thickness and length that cannot be explained with traditional nerve models. A necessary condition for solitary pulse propagation is the simultaneous existence of nonlinearity and dispersion, i.e., the dependence of the speed of sound on density and frequency. A prerequisite for the nonlinearity is the presence of a chain melting transition close to physiological temperatures. The transition causes a density dependence of the elastic constants which can easily be determined by experiment. The frequency dependence is more difficult to determine. The typical time scale of a nerve pulse is 1 ms, corresponding to a characteristic frequency in the range up to one kHz. Dispersion in the sub-kHz regime is difficult to measure due to the very long wave lengths involved. In this contribution we address theoretically the dispersion of the speed of sound in lipid membranes and relate it to experimentally accessible relaxation times by using linear response theory. This ultimately leads to an extension of the differential equation for soliton propagation.

physics.bio-ph

Periodic solutions and refractory periods in the soliton theory for nerves and the locust femoral nerve

Close to melting transitions it is possible to propagate solitary electromechanical pulses which reflect many of the experimental features of the nerve pulse including mechanical dislocations and reversible heat production. Here we show that one also obtains the possibility of periodic pulse generation when the boundary condition for the nerve is the conservation of the overall length of the nerve. This condition generates an undershoot beneath the baseline (`hyperpolarization') and a `refractory period', i.e., a minimum distance between pulses. In this paper, we outline the theory for periodic solutions to the wave equation and compare these results to action potentials from the femoral nerve of the locust (locusta migratoria). In particular, we describe the frequently occurring minimum-distance doublet pulses seen in these neurons and compare them to the periodic pulse solutions.

physics.bio-ph

Comment: Citation Statistics

We discuss the paper "Citation Statistics" by the Joint Committee on Quantitative Assessment of Research [arXiv:0910.3529]. In particular, we focus on a necessary feature of "good" measures for ranking scientific authors: that good measures must able to accurately distinguish between authors.

stat.ME

Statistics of trajectories in two-state master equations

We derive a simple expression for the probability of trajectories of a master equation. The expression is particularly useful when the number of states is small and permits the calculation of observables that can be defined as functionals of whole trajectories. We illustrate the method with a two-state master equation, for which we calculate the distribution of the time spent in one state and the distribution of the number of transitions, each in a given time interval. These two expressions are obtained analytically in terms of modified Bessel functions.

cond-mat.stat-mech

On the action potential as a propagating density pulse and the role of anesthetics

The Hodgkin-Huxley model of nerve pulse propagation relies on ion currents through specific resistors called ion channels. We discuss a number of classical thermodynamic findings on nerves that are not contained in this classical theory. Particularly striking is the finding of reversible heat changes, thickness and phase changes of the membrane during the action potential. Data on various nerves rather suggest that a reversible density pulse accompanies the action potential of nerves. Here, we attempted to explain these phenomena by propagating solitons that depend on the presence of cooperative phase transitions in the nerve membrane. These transitions are, however, strongly influenced by the presence of anesthetics. Therefore, the thermodynamic theory of nerve pulses suggests a explanation for the famous Meyer-Overton rule that states that the critical anesthetic dose is linearly related to the solubility of the drug in the membranes.

physics.bio-ph

The thermodynamics of general anesthesia

It is known that the action of general anesthetics is proportional to their partition coefficient in lipid membranes (Meyer-Overton rule). This solubility is, however, directly related to the depression of the temperature of the melting transition found close to body temperature in biomembranes. We propose a thermodynamic extension of the Meyer-Overton rule which is based on free energy changes in the system and thus automatically incorporates the effects of melting point depression. This model provides a quantitative explanation of the pressure reversal of anesthesia. Further, it explains why inflammation and the addition of divalent cations reduce the effectiveness of anesthesia.

physics.bio-ph