arXiv subjects

Andrew W. Senior

Publications and source records attributed to Andrew W. Senior.

5 recordsLinked to original sources

arXiv2026

Reinforcement Learning Control of Quantum Error Correction

Quantum error correction (QEC) is the primary strategy for protecting a quantum computer from the environment. Its prerequisite is that errors must remain sufficiently rare, which requires perpetually adapting the computer's control parameters to the drifting environment conditions. The current solution to this problem is to terminate the entire quantum computation for recalibration, but it is incompatible with the long runtimes of future quantum algorithms. We address this challenge by unifying calibration with computation. We grant the QEC process a dual role: its error detection events are not only used to correct the logical quantum state, but are also repurposed as a learning signal, teaching a reinforcement learning (RL) agent to continuously steer the control parameters and stabilize the quantum system during computation. We experimentally demonstrate this framework on a Willow superconducting processor, improving the logical stability of the surface code 3.5-fold against injected drift. By synthesizing our full suite of technological advances, we achieve record performance of the surface and color codes, with average logical error per cycle of $7.72(9)\times10^{-4}$ and $8.19(14)\times10^{-3}$ respectively. Numerical simulations of large codes with tens of thousands of control parameters confirm the scalability of our RL framework, revealing an optimization speed that is independent of system size. This work thus enables a new paradigm: a quantum computer that learns from its errors and never stops computing.

quant-ph↗

arXiv2026

A scalable and real-time neural decoder for topological quantum codes

Fault-tolerant quantum computing will require error rates far below those achievable with physical qubits. Quantum error correction (QEC) bridges this gap, but depends on decoders being simultaneously fast, accurate, and scalable. This combination of requirements remains unmet by a machine-learning decoder, nor by any decoder for promising resource-efficient codes such as the color code. Here we introduce AlphaQubit 2, a neural-network decoder that achieves near-optimal logical error rates for both surface and color codes at scale under realistic noise. For the color code, it is orders of magnitude faster than other high-accuracy decoders. We demonstrate real-time decoding faster than 1μs per cycle on commercial accelerators: for the surface code to distance 11, with better accuracy than leading real-time decoders; and the first real-time decoding of the color code to distance 9. These results support the practical application of a wider class of promising QEC codes, and establish a credible path towards high-accuracy, real-time neural decoding at the scales required for fault-tolerant quantum computation.

quant-ph↗

arXiv2024

Scaling and logic in the color code on a superconducting quantum processor

Quantum error correction is essential for bridging the gap between the error rates of physical devices and the extremely low logical error rates required for quantum algorithms. Recent error-correction demonstrations on superconducting processors have focused primarily on the surface code, which offers a high error threshold but poses limitations for logical operations. In contrast, the color code enables much more efficient logic, although it requires more complex stabilizer measurements and decoding techniques. Measuring these stabilizers in planar architectures such as superconducting qubits is challenging, and so far, realizations of color codes have not addressed performance scaling with code size on any platform. Here, we present a comprehensive demonstration of the color code on a superconducting processor, achieving logical error suppression and performing logical operations. Scaling the code distance from three to five suppresses logical errors by a factor of $Λ_{3/5}$ = 1.56(4). Simulations indicate this performance is below the threshold of the color code, and furthermore that the color code may be more efficient than the surface code with modest device improvements. Using logical randomized benchmarking, we find that transversal Clifford gates add an error of only 0.0027(3), which is substantially less than the error of an idling error correction cycle. We inject magic states, a key resource for universal computation, achieving fidelities exceeding 99% with post-selection (retaining about 75% of the data). Finally, we successfully teleport logical states between distance-three color codes using lattice surgery, with teleported state fidelities between 86.5(1)% and 90.7(1)%. This work establishes the color code as a compelling research direction to realize fault-tolerant quantum computation on superconducting processors in the near future.

quant-ph↗

arXiv2024

De novo design of high-affinity protein binders with AlphaProteo

Computational design of protein-binding proteins is a fundamental capability with broad utility in biomedical research and biotechnology. Recent methods have made strides against some target proteins, but on-demand creation of high-affinity binders without multiple rounds of experimental testing remains an unsolved challenge. This technical report introduces AlphaProteo, a family of machine learning models for protein design, and details its performance on the de novo binder design problem. With AlphaProteo, we achieve 3- to 300-fold better binding affinities and higher experimental success rates than the best existing methods on seven target proteins. Our results suggest that AlphaProteo can generate binders "ready-to-use" for many research applications using only one round of medium-throughput screening and no further optimization.

q-bio.BM↗

arXiv2021

Inferring a Continuous Distribution of Atom Coordinates from Cryo-EM Images using VAEs

Cryo-electron microscopy (cryo-EM) has revolutionized experimental protein structure determination. Despite advances in high resolution reconstruction, a majority of cryo-EM experiments provide either a single state of the studied macromolecule, or a relatively small number of its conformations. This reduces the effectiveness of the technique for proteins with flexible regions, which are known to play a key role in protein function. Recent methods for capturing conformational heterogeneity in cryo-EM data model it in volume space, making recovery of continuous atomic structures challenging. Here we present a fully deep-learning-based approach using variational auto-encoders (VAEs) to recover a continuous distribution of atomic protein structures and poses directly from picked particle images and demonstrate its efficacy on realistic simulated data. We hope that methods built on this work will allow incorporation of stronger prior information about protein structure and enable better understanding of non-rigid protein structures.

cs.CE↗