arXiv subjects

Andrew Zhang

Publications and source records attributed to Andrew Zhang.

At least 19 recordsLinked to original sources

arXiv2026

When Compression Scores Cannot Decide: Information Boundaries for Group-Robust LLM Pruning

A stable compression score can still select the worse model. In our dense study, a split-half reliable path-quadratic score predicted a 16.1\% gain, while the selected endpoints were 6.0--7.7% worse than two controls. We ask what a compression statistic can justify when deployment cares about the worst supplied group. We treat each statistic as an information interface. Its observation leaves a fiber of compatible endpoint-risk tables, and only orders fixed across that fiber are identified. Cone and fiber identities quantify the remaining uncertainty, while matched observations reverse endpoint order for pooled moments, group-local moments, and reference-path curvature. Sequential composition adds one state variable: the slack from each group risk to the current maximum. This vector determines every unrestricted one-step response, and a margin condition keeps the active group fixed along paths with bounded relative drift. The experiments follow the same ladder. Across three dense LLMs, an early-preserving allocation reduces worst-group perplexity inflation by 12.6--20.9%; target-matched complete-menu selection improves over its references by 2.7--8.0%. Across all 16 routed layers of OLMoE, pooled endpoint refresh lowers held-out worst-group teacher KL by 15.8% over the best static score. A compute-matched hard-max trajectory ends 32.7% worse than pooled, and neither adaptive trajectory improves excess NLL. Local evidence can narrow a menu. Complete endpoints rank that menu, while multistep claims also require control of the evolving active face and future candidates.

cs.AI↗

arXiv2026

Agent Step Value: Auditing Evaluator-Channel Reversals in Black-Box Agent Traces

Pooling, substituting, or reusing evaluator-derived step rewards assumes that their direction survives a change of evaluation channel. The same frozen transition can violate that assumption. Process rewards vary agent states, while evaluator audits vary scoring configurations; neither first difference isolates their interaction. We define Agent Step Value (ASV) as a channel-indexed target-margin gain and identify the state-by-channel interaction on complete matched faces. Across frozen PubMed question-answering transitions, direct scoring yields a positive mean ASV, while the generated-view channel yields a negative mean. Two matched replay waves reproduce this reversal, and cross-channel sign disagreement exceeds same-channel retry disagreement by 48.0 percentage points. Matched retrieval faces localize the reversal to the generated-view coordinate and trace its direction across a readout-and-stack bridge. A source-only generation contract restores the positive mean direction on artifact-bearing retrievals and removes parser-detected substantive support claims from artifact-free before-state views. ASV turns channel sensitivity into an identified measurement problem that can be localized and tested by intervention before step rewards are reused.

cs.AI↗

arXiv2026

Posterior-Aware Differential Channel Tracking for Reliable Single-Stream DAB+ Passive Radar

Digital audio broadcasting plus (DAB+) is an attractive illuminator for passive radar because it provides persistent, high-power, and geographically widespread very high frequency (VHF) orthogonal frequency-division multiplexing (OFDM) signals. A channel state information (CSI) sensing approach can convert a single received DAB+ stream into a CSI sequence for radar sensing, avoiding the need for a separately received reference signal in conventional passive radars. However, CSI estimation in DAB+ is challenging due to the differentially encoded communication symbols across time. A wrong symbol transition estimation leads to a persistent multiplicative error in the sequential CSI sequence within a DAB+ frame. This paper formulates single-stream DAB+ passive radar as a posterior-probability-aware differential CSI tracking problem. The proposed method uses the previously tracked CSI as a channel prior, performs prediction-aided maximum a posteriori detection of current symbol, converts posterior transition reliability into observation uncertainty, and applies linear minimum mean squared error fusion to obtain a stable tracking CSI. A reliability-informed CSI fusion strategy is also introduced to preserve weak target information. Theoretical analysis is provided, showing guaranteed performance again in symbol and CSI estimation. Simulation results show that the proposed method can reduce CSI estimation error by over 15~dB compared with prior art. It also improves median target-to-background ratio by more than 11~dB in random fading scenes. Experiments in Sydney, Australia demonstrate improved range-Doppler maps for commercial aircraft sensing.

eess.SP↗

arXiv2026

A multimodal and temporal foundation model for virtual patient representations at healthcare system scale

Modern medicine generates vast multimodal data across siloed systems, yet no existing model integrates the full breadth and temporal depth of the clinical record into a unified patient representation. We introduce Apollo, a multimodal temporal foundation model trained and evaluated on over three decades of longitudinal hospital records from a major US hospital system, composed of 25 billion records from 7.2 million patients, representing 28 distinct medical modalities and 12 major medical specialties. Apollo learns a unified representation space integrating over 100 thousand unique medical events in our clinical vocabulary as well as images and clinical text. This "atlas of medical concepts" forms a computational substrate for modeling entire patient care journeys comprised of sequences of structured and unstructured events, which are compressed by Apollo into virtual patient representations. To assess the potential of these whole-patient representations, we created 322 prognosis and retrieval tasks from a held-out test set of 1.4 million patients. We demonstrate the generalized clinical forecasting potential of Apollo embeddings, including predicting new disease onset risk up to five years in advance (95 tasks), disease progression (78 tasks), treatment response (59 tasks), risk of treatment-related adverse events (17 tasks), and hospital operations endpoints (12 tasks). Using feature attribution techniques, we show that model predictions align with clinically-interpretable multimodal biomarkers. We evaluate semantic similarity search on 61 retrieval tasks, and moreover demonstrate the potential of Apollo as a multimodal medical search engine using text and image queries. Together, these modeling capabilities establish the foundation for computable medicine, where the full context of patient care becomes accessible to computational reasoning.

cs.LG↗

arXiv2026

Persona Vectors in Games: Measuring and Steering Strategies via Activation Vectors

Large language models (LLMs) are increasingly deployed as autonomous decision-makers in strategic settings, yet we have limited tools for understanding their high-level behavioral traits. We use activation steering methods in game-theoretic settings, constructing persona vectors for altruism, forgiveness, and expectations of others by contrastive activation addition. Evaluating on canonical games, we find that activation steering systematically shifts both quantitative strategic choices and natural-language justifications. However, we also observe that rhetoric and strategy can diverge under steering. In addition, vectors for self-behavior and expectations of others are partially distinct. Our results suggest that persona vectors offer a promising mechanistic handle on high-level traits in strategic environments.

cs.AI↗

arXiv2026

The multi-wavelength vertical structure of the archetypal $\beta$ Pictoris debris disk

Thermal imaging of debris disks is resolving the vertical height in an increasing number of systems, enabling the use of the vertical structure to decode the dynamical state of the planetary system. In this study, we examine the multi-wavelength structure of the archetypical edge-on debris disk of $\beta$ Pic, extensive imaging of which across mid-infrared to millimeter wavelengths makes it the prime system to study the vertical height across different grain size populations. We non-parametrically modelled the radial profiles and constrained the vertical height at each wavelength while taking into account the vertical warping, finding the disk to be on average 1.5 times thicker vertically in the mid-infrared compared to the millimeter and the scale height to be relatively constant across radius. The decreasing scale height with wavelength is in contrast to predictions from collisional damping, and could be a result of the combined effect of radiation pressure and random collisions. We also show that the disk is warped at millimeter wavelengths and find tentative evidence for clumps in ALMA images which will require follow-up observations to confirm. The millimeter vertical warping is consistent with findings in scattered light and the secular perturbation interpretation due to the inner giant planets, which could also explain the relatively constant apparent scale height across radius, and potentially earlier findings of a non-Gaussian vertical profile which this study confirms.

astro-ph.EP↗

arXiv2025

SteerVLM: Robust Model Control through Lightweight Activation Steering for Vision Language Models

This work introduces SteerVLM, a lightweight steering module designed to guide Vision-Language Models (VLMs) towards outputs that better adhere to desired instructions. Our approach learns from the latent embeddings of paired prompts encoding target and converse behaviors to dynamically adjust activations connecting the language modality with image context. This allows for fine-grained, inference-time control over complex output semantics without modifying model weights while preserving performance on off-target tasks. Our steering module requires learning parameters equal to 0.14% of the original VLM's size. Our steering module gains model control through dimension-wise activation modulation and adaptive steering across layers without requiring pre-extracted static vectors or manual tuning of intervention points. Furthermore, we introduce VNIA (Visual Narrative Intent Alignment), a multimodal dataset specifically created to facilitate the development and evaluation of VLM steering techniques. Our method outperforms existing intervention techniques on steering and hallucination mitigation benchmarks for VLMs and proposes a robust solution for multimodal model control through activation engineering.

cs.CV↗

arXiv2025

Zero-Shot Fine-Grained Image Classification Using Large Vision-Language Models

Large Vision-Language Models (LVLMs) have demonstrated impressive performance on vision-language reasoning tasks. However, their potential for zero-shot fine-grained image classification, a challenging task requiring precise differentiation between visually similar categories, remains underexplored. We present a novel method that transforms zero-shot fine-grained image classification into a visual question-answering framework, leveraging LVLMs' comprehensive understanding capabilities rather than relying on direct class name generation. We enhance model performance through a novel attention intervention technique. We also address a key limitation in existing datasets by developing more comprehensive and precise class description benchmarks. We validate the effectiveness of our method through extensive experimentation across multiple fine-grained image classification benchmarks. Our proposed method consistently outperforms the current state-of-the-art (SOTA) approach, demonstrating both the effectiveness of our method and the broader potential of LVLMs for zero-shot fine-grained classification tasks. Code and Datasets: https://github.com/Atabuzzaman/Fine-grained-classification

cs.CV↗

arXiv2025

Maximal Matching Matters: Preventing Representation Collapse for Robust Cross-Modal Retrieval

Cross-modal image-text retrieval is challenging because of the diverse possible associations between content from different modalities. Traditional methods learn a single-vector embedding to represent semantics of each sample, but struggle to capture nuanced and diverse relationships that can exist across modalities. Set-based approaches, which represent each sample with multiple embeddings, offer a promising alternative, as they can capture richer and more diverse relationships. In this paper, we show that, despite their promise, these set-based representations continue to face issues including sparse supervision and set collapse, which limits their effectiveness. To address these challenges, we propose Maximal Pair Assignment Similarity to optimize one-to-one matching between embedding sets which preserve semantic diversity within the set. We also introduce two loss functions to further enhance the representations: Global Discriminative Loss to enhance distinction among embeddings, and Intra-Set Divergence Loss to prevent collapse within each set. Our method achieves state-of-the-art performance on MS-COCO and Flickr30k without relying on external data.

cs.CV↗

arXiv2025

Flexible-length Text Infilling for Discrete Diffusion Models

Discrete diffusion models are a new class of text generators that offer advantages such as bidirectional context use, parallelizable generation, and flexible prompting compared to autoregressive models. However, a critical limitation of discrete diffusion models is their inability to perform flexible-length or flexible-position text infilling without access to ground-truth positional data. We introduce \textbf{DDOT} (\textbf{D}iscrete \textbf{D}iffusion with \textbf{O}ptimal \textbf{T}ransport Position Coupling), the first discrete diffusion model to overcome this challenge. DDOT jointly denoises token values and token positions, employing a novel sample-level Optimal Transport (OT) coupling. This coupling preserves relative token ordering while dynamically adjusting the positions and length of infilled segments, a capability previously missing in text diffusion. Our method is orthogonal to existing discrete text diffusion methods and is compatible with various pretrained text denoisers. Extensive experiments on text infilling benchmarks such as One-Billion-Word and Yelp demonstrate that DDOT outperforms naive diffusion baselines. Furthermore, DDOT achieves performance on par with state-of-the-art non-autoregressive models and enables significant improvements in training efficiency and flexibility.

cs.LG↗

arXiv2025

A Foundation Model for Spatial Proteomics

Foundation models have begun to transform image analysis by acting as pretrained generalist backbones that can be adapted to many tasks even when post-training data are limited, yet their impact on spatial proteomics, imaging that maps proteins at single-cell resolution, remains limited. Here, we introduce KRONOS, a foundation model built for spatial proteomics. KRONOS was trained in a self-supervised manner on over 47 million image patches covering 175 protein markers, 16 tissue types, and 8 fluorescence-based imaging platforms. We introduce key architectural adaptations to address the high-dimensional, multi-channel, and heterogeneous nature of multiplex imaging. We demonstrate that KRONOS learns biologically meaningful representations across multiple scales, ranging from cellular and microenvironment to tissue levels, enabling it to address diverse downstream tasks, including cell phenotyping, region classification, and patient stratification. Evaluated across 11 independent cohorts, KRONOS achieves state-of-the-art performance across cell phenotyping, treatment response prediction, and retrieval tasks, and is highly data-efficient. KRONOS also introduces the paradigm of segmentation-free patch-level processing for efficient and scalable spatial proteomics analysis, allowing cross-institutional comparisons, and as an image reverse search engine for spatial patterns. Together, these results position KRONOS as a flexible and scalable tool for spatial proteomics. The model is publicly accessible at https://github.com/mahmoodlab/KRONOS.

cs.CV↗

arXiv2025

MAISY: Motion-Aware Image SYnthesis for Medical Image Motion Correction

Patient motion during medical image acquisition causes blurring, ghosting, and distorts organs, which makes image interpretation challenging. Current state-of-the-art algorithms using Generative Adversarial Network (GAN)-based methods with their ability to learn the mappings between corrupted images and their ground truth via Structural Similarity Index Measure (SSIM) loss effectively generate motion-free images. However, we identified the following limitations: (i) they mainly focus on global structural characteristics and therefore overlook localized features that often carry critical pathological information, and (ii) the SSIM loss function struggles to handle images with varying pixel intensities, luminance factors, and variance. In this study, we propose Motion-Aware Image SYnthesis (MAISY) which initially characterize motion and then uses it for correction by: (a) leveraging the foundation model Segment Anything Model (SAM), to dynamically learn spatial patterns along anatomical boundaries where motion artifacts are most pronounced and, (b) introducing the Variance-Selective SSIM (VS-SSIM) loss which adaptively emphasizes spatial regions with high pixel variance to preserve essential anatomical details during artifact correction. Experiments on chest and head CT datasets demonstrate that our model outperformed the state-of-the-art counterparts, with Peak Signal-to-Noise Ratio (PSNR) increasing by 40%, SSIM by 10%, and Dice by 16%.

eess.IV↗

arXiv2025

Accelerating Data Processing and Benchmarking of AI Models for Pathology

Advances in foundation modeling have reshaped computational pathology. However, the increasing number of available models and lack of standardized benchmarks make it increasingly complex to assess their strengths, limitations, and potential for further development. To address these challenges, we introduce a new suite of software tools for whole-slide image processing, foundation model benchmarking, and curated publicly available tasks. We anticipate that these resources will promote transparency, reproducibility, and continued progress in the field.

cs.CV↗

arXiv2025

Molecular-driven Foundation Model for Oncologic Pathology

Foundation models are reshaping computational pathology by enabling transfer learning, where models pre-trained on vast datasets can be adapted for downstream diagnostic, prognostic, and therapeutic response tasks. Despite these advances, foundation models are still limited in their ability to encode the entire gigapixel whole-slide images without additional training and often lack complementary multimodal data. Here, we introduce Threads, a slide-level foundation model capable of generating universal representations of whole-slide images of any size. Threads was pre-trained using a multimodal learning approach on a diverse cohort of 47,171 hematoxylin and eosin (H&E)-stained tissue sections, paired with corresponding genomic and transcriptomic profiles - the largest such paired dataset to be used for foundation model development to date. This unique training paradigm enables Threads to capture the tissue's underlying molecular composition, yielding powerful representations applicable to a wide array of downstream tasks. In extensive benchmarking across 54 oncology tasks, including clinical subtyping, grading, mutation prediction, immunohistochemistry status determination, treatment response prediction, and survival prediction, Threads outperformed all baselines while demonstrating remarkable generalizability and label efficiency. It is particularly well suited for predicting rare events, further emphasizing its clinical utility. We intend to make the model publicly available for the broader community.

cs.CV↗

arXiv2024

Multimodal Whole Slide Foundation Model for Pathology

The field of computational pathology has been transformed with recent advances in foundation models that encode histopathology region-of-interests (ROIs) into versatile and transferable feature representations via self-supervised learning (SSL). However, translating these advancements to address complex clinical challenges at the patient and slide level remains constrained by limited clinical data in disease-specific cohorts, especially for rare clinical conditions. We propose TITAN, a multimodal whole slide foundation model pretrained using 335,645 WSIs via visual self-supervised learning and vision-language alignment with corresponding pathology reports and 423,122 synthetic captions generated from a multimodal generative AI copilot for pathology. Without any finetuning or requiring clinical labels, TITAN can extract general-purpose slide representations and generate pathology reports that generalize to resource-limited clinical scenarios such as rare disease retrieval and cancer prognosis. We evaluate TITAN on diverse clinical tasks and find that TITAN outperforms both ROI and slide foundation models across machine learning settings such as linear probing, few-shot and zero-shot classification, rare cancer retrieval and cross-modal retrieval, and pathology report generation.

eess.IV↗

arXiv2024

Multistain Pretraining for Slide Representation Learning in Pathology

Developing self-supervised learning (SSL) models that can learn universal and transferable representations of H&E gigapixel whole-slide images (WSIs) is becoming increasingly valuable in computational pathology. These models hold the potential to advance critical tasks such as few-shot classification, slide retrieval, and patient stratification. Existing approaches for slide representation learning extend the principles of SSL from small images (e.g., 224 x 224 patches) to entire slides, usually by aligning two different augmentations (or views) of the slide. Yet the resulting representation remains constrained by the limited clinical and biological diversity of the views. Instead, we postulate that slides stained with multiple markers, such as immunohistochemistry, can be used as different views to form a rich task-agnostic training signal. To this end, we introduce Madeleine, a multimodal pretraining strategy for slide representation learning. Madeleine is trained with a dual global-local cross-stain alignment objective on large cohorts of breast cancer samples (N=4,211 WSIs across five stains) and kidney transplant samples (N=12,070 WSIs across four stains). We demonstrate the quality of slide representations learned by Madeleine on various downstream evaluations, ranging from morphological and molecular classification to prognostic prediction, comprising 21 tasks using 7,299 WSIs from multiple medical centers. Code is available at https://github.com/mahmoodlab/MADELEINE.

eess.IV↗

arXiv2024

MedCalc-Bench: Evaluating Large Language Models for Medical Calculations

As opposed to evaluating computation and logic-based reasoning, current benchmarks for evaluating large language models (LLMs) in medicine are primarily focused on question-answering involving domain knowledge and descriptive reasoning. While such qualitative capabilities are vital to medical diagnosis, in real-world scenarios, doctors frequently use clinical calculators that follow quantitative equations and rule-based reasoning paradigms for evidence-based decision support. To this end, we propose MedCalc-Bench, a first-of-its-kind dataset focused on evaluating the medical calculation capability of LLMs. MedCalc-Bench contains an evaluation set of over 1000 manually reviewed instances from 55 different medical calculation tasks. Each instance in MedCalc-Bench consists of a patient note, a question requesting to compute a specific medical value, a ground truth answer, and a step-by-step explanation showing how the answer is obtained. While our evaluation results show the potential of LLMs in this area, none of them are effective enough for clinical settings. Common issues include extracting the incorrect entities, not using the correct equation or rules for a calculation task, or incorrectly performing the arithmetic for the computation. We hope our study highlights the quantitative knowledge and reasoning gaps in LLMs within medical settings, encouraging future improvements of LLMs for various clinical calculation tasks.

cs.CL↗

arXiv2023

Depth-multiplexing spectral domain OCT for full eye length imaging with a single modulation unit

Clinical measurement of a patient's axial eye length is emerging as a crucial approach to track progression and monitor management of myopia. However, the preferred method for such measurements is swept-source OCT, whose cost prohibits broad use, especially in lower-income communities. Spectral domain (SD) OCT is a more affordable option, but it has limited imaging depth range, so is not suitable for full eye length measurement. Depth-multiplexing (DM) techniques for SD-OCT provide a workaround by capturing images at multiple depths within the eye. However, these methods typically require multiple light modulation units or detectors for simultaneous imaging across depths, adding complexity and cost. In response, we propose a novel DM-SD-OCT approach that utilizes a single light modulation unit for depth encoding. We capture images at multiple depths within the eye simultaneously with a single line scan camera, then computationally demix the contributions from different depths. Here, we demonstrate acquisition and demixing of signals from three distinct depths within the eye and validate experimentally in human subjects. Our method thus offers a cost-effective solution for comprehensive eye length measurement in clinical myopia research.

physics.optics↗