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Anke Scheel-Sailer

Publications and source records attributed to Anke Scheel-Sailer.

2 recordsLinked to original sources

Causal graph fusion across incomplete cohorts and causal steering of tabular foundation models

Clinical data are split across incomplete cohorts with partially overlapping variables. Causal discovery under missing data and multi-source integration have developed separately, and tabular foundation models cannot take a causal graph without retraining. We make two contributions. First, causal graph fusion learns a partial ancestral graph on the shared variables, fuses it into each cohort's graph under temporal background knowledge and lets Markov blankets guide re-imputation, so missing data are handled inside discovery. Second, causal attention steering compiles the learned graph into the attention of a frozen tabular foundation model at inference. Against known ground truth, fusion dominates pooled and per-cohort baselines in every missingness and heterogeneity condition tested (p<0.001), and steering improves discrimination under distribution shift (p<10^{-5}), a gain that a random graph does not produce. In two spinal cord injury cohorts, fusion orients age, albumin and hemoglobin as ancestors of length of stay, a set no single cohort orients in full, and yields compact, temporally ordered predictor sets that match or exceed automatic feature selection on four of five outcomes.

cs.LG↗

Detection of Autonomic Dysreflexia in Individuals With Spinal Cord Injury Using Multimodal Wearable Sensors

Autonomic Dysreflexia (AD) is a potentially life-threatening condition characterized by sudden, severe blood pressure (BP) spikes in individuals with spinal cord injury (SCI). Early, accurate detection is essential to prevent cardiovascular complications, yet current monitoring methods are either invasive or rely on subjective symptom reporting, limiting applicability in daily file. This study presents a non-invasive, explainable machine learning framework for detecting AD using multimodal wearable sensors. Data were collected from 27 individuals with chronic SCI during urodynamic studies, including electrocardiography (ECG), photoplethysmography (PPG), bioimpedance (BioZ), temperature, respiratory rate (RR), and heart rate (HR), across three commercial devices. Objective AD labels were derived from synchronized cuff-based BP measurements. Following signal preprocessing and feature extraction, BorutaSHAP was used for robust feature selection, and SHAP values for explainability. We trained modality- and device-specific weak learners and aggregated them using a stacked ensemble meta-model. Cross-validation was stratified by participants to ensure generalizability. HR- and ECG-derived features were identified as the most informative, particularly those capturing rhythm morphology and variability. The Nearest Centroid ensemble yielded the highest performance (Macro F1 = 0.77+/-0.03), significantly outperforming baseline models. Among modalities, HR achieved the highest area under the curve (AUC = 0.93), followed by ECG (0.88) and PPG (0.86). RR and temperature features contributed less to overall accuracy, consistent with missing data and low specificity. The model proved robust to sensor dropout and aligned well with clinical AD events. These results represent an important step toward personalized, real-time monitoring for individuals with SCI.

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